Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis / Xingxing LIAO ; Kaiyue HAN ; Maoyuan NIU ; Jiarou CHEN ; Xianna WANG ; Jianjun LIU ; Yan ZHANG ; Hao ZHANG in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1497-1512 Titre : Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Xingxing LIAO, Auteur ; Kaiyue HAN, Auteur ; Maoyuan NIU, Auteur ; Jiarou CHEN, Auteur ; Xianna WANG, Auteur ; Jianjun LIU, Auteur ; Yan ZHANG, Auteur ; Hao ZHANG, Auteur Article en page(s) : p.1497-1512 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  insulin-like growth factor-1  meta-analysis  systematic review  thyroid hormone Index. décimale : PER Périodiques Résumé : ABSTRACT The action of the thyroid hormones and insulin-like growth factor 1 (IGF-1) is interdependent. The levels of thyroid hormone and IGF-1 were reported to be altered in individuals with autism spectrum disorder (ASD), but the results were controversial. This study aims to compare levels of thyroxine, triiodothyronine, thyroid stimulating hormone, and IGF-1 between the ASD group and neurotypical controls. PubMed, Web of Science, Cochrane, and Embase databases were searched for eligible observational studies. We calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) of our data using a random or fixed effect model. The search strategy provided a total of 1710 articles, of which 16 articles were quantitatively analyzed. The total number of included participants was 2399 (1285 cases and 1114 controls). The meta-analysis revealed no significantly changed blood levels of thyroxine, free triiodothyronine, free thyroxine, and IGF-1 of subjects with ASD compared to non-autistic controls. The blood TSH levels were significantly lower in ASD subjects than in controls (n 859, Hedges' g 1.18, 95% CI: 2.17 to 0.20, p 0.02). Subgroup-analysis results showed that blood free triiodothyronine (n 153, Hedges' g 0.74, 95% CI: 1.08 to 0.40, p?< 0.0001, I2 2%), free thyroxine (n 153, Hedges' g 0.72, 95% CI: 1.31 to 0.14, p 0.02, I2 66%), and IGF-1 (n 397; Hedges' g 0.92; 95% CI: 1.30 to 0.55, p?< 0.00001, I2 63%) levels were significantly reduced in subjects with severe ASD symptoms. Individuals with severe ASD may experience a dysfunction of the hypothalamic?pituitary?thyroid axis, and further studies are warranted to determine the correlation between thyroid hormone and IGF-1 levels and disease severity. Trial Registration: ClinicalTrials.gov identifiers: NCT01970345 En ligne : https://doi.org/10.1002/aur.70052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Association of Thyroid Hormone and Insulin-Like Growth Factor-1 Levels With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis [texte imprimé] / Xingxing LIAO, Auteur ; Kaiyue HAN, Auteur ; Maoyuan NIU, Auteur ; Jiarou CHEN, Auteur ; Xianna WANG, Auteur ; Jianjun LIU, Auteur ; Yan ZHANG, Auteur ; Hao ZHANG, Auteur . - p.1497-1512. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1497-1512 Mots-clés : autism spectrum disorder  insulin-like growth factor-1  meta-analysis  systematic review  thyroid hormone Index. décimale : PER Périodiques Résumé : ABSTRACT The action of the thyroid hormones and insulin-like growth factor 1 (IGF-1) is interdependent. The levels of thyroid hormone and IGF-1 were reported to be altered in individuals with autism spectrum disorder (ASD), but the results were controversial. This study aims to compare levels of thyroxine, triiodothyronine, thyroid stimulating hormone, and IGF-1 between the ASD group and neurotypical controls. PubMed, Web of Science, Cochrane, and Embase databases were searched for eligible observational studies. We calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) of our data using a random or fixed effect model. The search strategy provided a total of 1710 articles, of which 16 articles were quantitatively analyzed. The total number of included participants was 2399 (1285 cases and 1114 controls). The meta-analysis revealed no significantly changed blood levels of thyroxine, free triiodothyronine, free thyroxine, and IGF-1 of subjects with ASD compared to non-autistic controls. The blood TSH levels were significantly lower in ASD subjects than in controls (n 859, Hedges' g 1.18, 95% CI: 2.17 to 0.20, p 0.02). Subgroup-analysis results showed that blood free triiodothyronine (n 153, Hedges' g 0.74, 95% CI: 1.08 to 0.40, p?< 0.0001, I2 2%), free thyroxine (n 153, Hedges' g 0.72, 95% CI: 1.31 to 0.14, p 0.02, I2 66%), and IGF-1 (n 397; Hedges' g 0.92; 95% CI: 1.30 to 0.55, p?< 0.00001, I2 63%) levels were significantly reduced in subjects with severe ASD symptoms. Individuals with severe ASD may experience a dysfunction of the hypothalamic?pituitary?thyroid axis, and further studies are warranted to determine the correlation between thyroid hormone and IGF-1 levels and disease severity. Trial Registration: ClinicalTrials.gov identifiers: NCT01970345 En ligne : https://doi.org/10.1002/aur.70052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Correction: Perception and Production of Pitch Information in Mandarin-Speaking Children with Autism Spectrum Disorders / Wen MA ; Xuequn DAI ; Hao ZHANG in Journal of Autism and Developmental Disorders, 55-2 (February 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-2 (February 2025) . - p.772-772 Titre : Correction: Perception and Production of Pitch Information in Mandarin-Speaking Children with Autism Spectrum Disorders : Journal of Autism and Developmental Disorders Type de document : texte imprimé Auteurs : Wen MA, Auteur ; Xuequn DAI, Auteur ; Hao ZHANG, Auteur Article en page(s) : p.772-772 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-024-06677-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Correction: Perception and Production of Pitch Information in Mandarin-Speaking Children with Autism Spectrum Disorders : Journal of Autism and Developmental Disorders [texte imprimé] / Wen MA, Auteur ; Xuequn DAI, Auteur ; Hao ZHANG, Auteur . - p.772-772. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-2 (February 2025) . - p.772-772 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-024-06677-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

The association between childhood maltreatment and drug use: A systematic review and multilevel meta-analysis / Yang LIU in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2575-2589 Titre : The association between childhood maltreatment and drug use: A systematic review and multilevel meta-analysis Type de document : texte imprimé Auteurs : Yang LIU, Auteur ; Hualing MIAO, Auteur ; Xiuqin BAO, Auteur ; Yizhi ZHANG, Auteur ; Hao ZHANG, Auteur ; Jia ZHANG, Auteur ; Cheng GUO, Auteur Article en page(s) : p.2575-2589 Langues : Anglais (eng) Mots-clés : childhood maltreatment  drug use  moderator analysis  multilevel meta-analysis  subtypes of childhood maltreatment Index. décimale : PER Périodiques Résumé : While there is evidence that childhood maltreatment (CM) is positively associated with drug use (DU), the strength and difference of the association between CM and its subtypes (hereafter CM + ST) and DU remains to be further explored. A multilevel meta-analysis was conducted on 101 independent studies reporting 333 effect sizes (N = 132,341; Mage = 24.65; 43.80%males). Results showed significantly positive correlations between CM + ST and DU (range from 0.109 to 0.185). The results of the subgroup analysis revealed notable disparities in the correlations between distinct CM subtypes and DU (F = 5.358, P<0.01). Specifically, the effect size for childhood sexual abuse (CSA) was significantly lower than childhood emotional maltreatment (CEM) and childhood physical maltreatment (CPM), while no significant difference was noted between the CEM and CPM groups. These effect sizes also varied across regions, drug types, gender, detection rate of CM, the presence or absence of alcohol in substances, publication status and measurement method. The significant yet differing correlations between different subtypes of CM and DU to some extent support the principle of equality in psychopathology. These findings help explain the relationship between CM + ST and DU laying the groundwork for further research into the intricate and complex associations between CM and DU. En ligne : https://dx.doi.org/10.1017/S095457942500029X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] The association between childhood maltreatment and drug use: A systematic review and multilevel meta-analysis [texte imprimé] / Yang LIU, Auteur ; Hualing MIAO, Auteur ; Xiuqin BAO, Auteur ; Yizhi ZHANG, Auteur ; Hao ZHANG, Auteur ; Jia ZHANG, Auteur ; Cheng GUO, Auteur . - p.2575-2589. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2575-2589 Mots-clés : childhood maltreatment  drug use  moderator analysis  multilevel meta-analysis  subtypes of childhood maltreatment Index. décimale : PER Périodiques Résumé : While there is evidence that childhood maltreatment (CM) is positively associated with drug use (DU), the strength and difference of the association between CM and its subtypes (hereafter CM + ST) and DU remains to be further explored. A multilevel meta-analysis was conducted on 101 independent studies reporting 333 effect sizes (N = 132,341; Mage = 24.65; 43.80%males). Results showed significantly positive correlations between CM + ST and DU (range from 0.109 to 0.185). The results of the subgroup analysis revealed notable disparities in the correlations between distinct CM subtypes and DU (F = 5.358, P<0.01). Specifically, the effect size for childhood sexual abuse (CSA) was significantly lower than childhood emotional maltreatment (CEM) and childhood physical maltreatment (CPM), while no significant difference was noted between the CEM and CPM groups. These effect sizes also varied across regions, drug types, gender, detection rate of CM, the presence or absence of alcohol in substances, publication status and measurement method. The significant yet differing correlations between different subtypes of CM and DU to some extent support the principle of equality in psychopathology. These findings help explain the relationship between CM + ST and DU laying the groundwork for further research into the intricate and complex associations between CM and DU. En ligne : https://dx.doi.org/10.1017/S095457942500029X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

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