Examining diurnal cortisol changes as a pathway linking childhood adversity to depressive symptoms during adolescence / Tamara LORENZ in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.974-985 Titre : Examining diurnal cortisol changes as a pathway linking childhood adversity to depressive symptoms during adolescence Type de document : texte imprimé Auteurs : Tamara LORENZ, Auteur ; Nathalie MICHELS, Auteur ; Matteo GILETTA, Auteur Article en page(s) : p.974-985 Langues : Anglais (eng) Mots-clés : Adolescents  HPA axis  childhood adversity  depression  salivary diurnal cortisol Index. décimale : PER Périodiques Résumé : This study examined whether childhood adversity, specifically threat-related adversity, was associated with within-person changes in the cortisol awakening response (CAR) and diurnal cortisol slope (DCS), and whether these changes predicted increased depressive symptoms during adolescence. We also explored sex differences. In total, 283 first-year secondary school students in Belgium (M = 12.48 years; SD = 0.39; 42.8% female) participated in six assessments over 2.5 years. Childhood adversity (psychological, physical, and sexual victimization) reported at the first three waves was averaged. CAR and DCS latent residual change scores were derived from salivary cortisol samples collected during waves 1 and 3. Depressive symptom changes were assessed in linear growth curve models using self-reports from waves 3 to 6. The childhood adversity × sex interaction significantly predicted CAR and DCS changes, indicating a blunted CAR across waves for victimized boys, and a blunted DCS for victimized girls. Childhood adversity predicted the depressive symptoms intercept. No other predictors were associated with the depressive symptoms intercept, and none were linked to the depressive symptoms slope. Thus, childhood adversity may be linked to changes in diurnal cortisol patterns that differ by sex. Evidence for diurnal cortisol changes as a pathway to increased depressive symptoms remains inconclusive. En ligne : https://dx.doi.org/10.1017/S0954579425100916 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Examining diurnal cortisol changes as a pathway linking childhood adversity to depressive symptoms during adolescence [texte imprimé] / Tamara LORENZ, Auteur ; Nathalie MICHELS, Auteur ; Matteo GILETTA, Auteur . - p.974-985. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.974-985 Mots-clés : Adolescents  HPA axis  childhood adversity  depression  salivary diurnal cortisol Index. décimale : PER Périodiques Résumé : This study examined whether childhood adversity, specifically threat-related adversity, was associated with within-person changes in the cortisol awakening response (CAR) and diurnal cortisol slope (DCS), and whether these changes predicted increased depressive symptoms during adolescence. We also explored sex differences. In total, 283 first-year secondary school students in Belgium (M = 12.48 years; SD = 0.39; 42.8% female) participated in six assessments over 2.5 years. Childhood adversity (psychological, physical, and sexual victimization) reported at the first three waves was averaged. CAR and DCS latent residual change scores were derived from salivary cortisol samples collected during waves 1 and 3. Depressive symptom changes were assessed in linear growth curve models using self-reports from waves 3 to 6. The childhood adversity × sex interaction significantly predicted CAR and DCS changes, indicating a blunted CAR across waves for victimized boys, and a blunted DCS for victimized girls. Childhood adversity predicted the depressive symptoms intercept. No other predictors were associated with the depressive symptoms intercept, and none were linked to the depressive symptoms slope. Thus, childhood adversity may be linked to changes in diurnal cortisol patterns that differ by sex. Evidence for diurnal cortisol changes as a pathway to increased depressive symptoms remains inconclusive. En ligne : https://dx.doi.org/10.1017/S0954579425100916 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence / Nathalie MICHELS ; George M. SLAVICH ; Matteo GILETTA in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Titre : Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence Type de document : texte imprimé Auteurs : Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur Article en page(s) : p.311-321 Langues : Anglais (eng) Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage 12.69 years; SD 0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6 months over 1.5 years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves ( 12 .13; 23 .12; 34 .08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence [texte imprimé] / Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur . - p.311-321. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage 12.69 years; SD 0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6 months over 1.5 years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves ( 12 .13; 23 .12; 34 .08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

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