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Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders / N.M. SHAKER in Autism - Open Access, 6-5 ([01/09/2016])
[article]
Titre : Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : N.M. SHAKER, Auteur ; G.R.A TAHA, Auteur ; H. KHOLEIF, Auteur ; N.M. SAYED, Auteur ; N.M. EL-SHEIKH, Auteur ; M.L. ABULMAGD, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : ASD Autoimmunity S100B protein Interleukin-6 Anti-transglutaminase antibody Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD. Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years. These levels were compared to those of 22 matched healthy children aged from 3 to 13 years. Assessment of clinical parameters and severity of autism was done using Gilliam Autism Rating Scale. Results: Autistic children showed higher significant serum S100B protein and IL-6 levels compared to healthy controls (P=0.003 and 0.002 respectively). No significant correlations were found between serum levels of S100B, IL-6, TG2 IgA and clinical parameters/severity of autism. Serum levels of S100B had significant negative correlation with TG2 IgA levels (P=0.037) and marginally significant positive correlation with IL-6 levels (P=0.05).Conclusion: The significant elevations of S100B and IL-6 levels in sera of autistic children possibly imply an underlying neuropathological condition in autistic patients. Anti-TG2 antibodies may not have a possible contributing role in some ASD children. More research is needed to investigate any possible link between serum S100B protein, IL-6 levels and other brain autoantibodies as potential indicators of brain autoimmunity in ASD patients. En ligne : https://dx.doi.org/10.4172/2165-7890.1000191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410
in Autism - Open Access > 6-5 [01/09/2016] . - 7 p.[article] Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders [Texte imprimé et/ou numérique] / N.M. SHAKER, Auteur ; G.R.A TAHA, Auteur ; H. KHOLEIF, Auteur ; N.M. SAYED, Auteur ; N.M. EL-SHEIKH, Auteur ; M.L. ABULMAGD, Auteur . - 7 p.
Langues : Anglais (eng)
in Autism - Open Access > 6-5 [01/09/2016] . - 7 p.
Mots-clés : ASD Autoimmunity S100B protein Interleukin-6 Anti-transglutaminase antibody Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD. Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years. These levels were compared to those of 22 matched healthy children aged from 3 to 13 years. Assessment of clinical parameters and severity of autism was done using Gilliam Autism Rating Scale. Results: Autistic children showed higher significant serum S100B protein and IL-6 levels compared to healthy controls (P=0.003 and 0.002 respectively). No significant correlations were found between serum levels of S100B, IL-6, TG2 IgA and clinical parameters/severity of autism. Serum levels of S100B had significant negative correlation with TG2 IgA levels (P=0.037) and marginally significant positive correlation with IL-6 levels (P=0.05).Conclusion: The significant elevations of S100B and IL-6 levels in sera of autistic children possibly imply an underlying neuropathological condition in autistic patients. Anti-TG2 antibodies may not have a possible contributing role in some ASD children. More research is needed to investigate any possible link between serum S100B protein, IL-6 levels and other brain autoantibodies as potential indicators of brain autoimmunity in ASD patients. En ligne : https://dx.doi.org/10.4172/2165-7890.1000191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children / A. E. RUSSELL in Journal of Child Psychology and Psychiatry, 60-10 (October 2019)
[article]
Titre : Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children Type de document : Texte imprimé et/ou numérique Auteurs : A. E. RUSSELL, Auteur ; J. HERON, Auteur ; D. GUNNELL, Auteur ; T. FORD, Auteur ; G. HEMANI, Auteur ; C. JOINSON, Auteur ; P. MORAN, Auteur ; C. RELTON, Auteur ; M. SUDERMAN, Auteur ; B. MARS, Auteur Article en page(s) : p.1094-1103 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children C-reactive protein Inflammation Self-harm adverse childhood experiences interleukin-6 mediation suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self-harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self-harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self-harm. METHODS: Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9 years old (yo), levels of the inflammatory markers interleukin-6 and C-reactive protein measured at 9.5 yo, and self-harm reported at 16 yo. RESULTS: The mean number of ACEs young people experienced was 1.41 (SE 0.03). Higher ACE scores were associated with an increased risk of self-harm at 16 yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18, p < 0.001). We did not find evidence of an indirect effect of ACEs on self-harm via inflammation (RR 1.00, 95% CI 1.00, 1.01, p = 0.38). CONCLUSIONS: Young people who have been exposed to ACEs are a group at high risk of self-harm. The association between ACEs and self-harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship. En ligne : http://dx.doi.org/10.1111/jcpp.13100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406
in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1094-1103[article] Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children [Texte imprimé et/ou numérique] / A. E. RUSSELL, Auteur ; J. HERON, Auteur ; D. GUNNELL, Auteur ; T. FORD, Auteur ; G. HEMANI, Auteur ; C. JOINSON, Auteur ; P. MORAN, Auteur ; C. RELTON, Auteur ; M. SUDERMAN, Auteur ; B. MARS, Auteur . - p.1094-1103.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1094-1103
Mots-clés : Avon Longitudinal Study of Parents and Children C-reactive protein Inflammation Self-harm adverse childhood experiences interleukin-6 mediation suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self-harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self-harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self-harm. METHODS: Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9 years old (yo), levels of the inflammatory markers interleukin-6 and C-reactive protein measured at 9.5 yo, and self-harm reported at 16 yo. RESULTS: The mean number of ACEs young people experienced was 1.41 (SE 0.03). Higher ACE scores were associated with an increased risk of self-harm at 16 yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18, p < 0.001). We did not find evidence of an indirect effect of ACEs on self-harm via inflammation (RR 1.00, 95% CI 1.00, 1.01, p = 0.38). CONCLUSIONS: Young people who have been exposed to ACEs are a group at high risk of self-harm. The association between ACEs and self-harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship. En ligne : http://dx.doi.org/10.1111/jcpp.13100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406