Striatal brain volume linked to severity of substance use in high-risk incarcerated youth / Nathaniel E. ANDERSON in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.966-975 Titre : Striatal brain volume linked to severity of substance use in high-risk incarcerated youth Type de document : Texte imprimé et/ou numérique Auteurs : Nathaniel E. ANDERSON, Auteur ; J. Michael MAURER, Auteur ; David STEPHENSON, Auteur ; Keith HARENSKI, Auteur ; Michael CALDWELL, Auteur ; Greg VAN RYBROEK, Auteur ; Kent A. KIEHL, Auteur Article en page(s) : p.966-975 Langues : Anglais (eng) Mots-clés : Antisocial behavior  MRI  brain volume  juvenile  substance use disorders Index. décimale : PER Périodiques Résumé : Substance use disorders among juveniles are a major public health concern and are often intertwined with other psychosocial risk factors including antisocial behavior. Identifying etiological risks and mechanisms promoting substance use disorders remains a high priority for informing more focused interventions in high-risk populations. The present study examined brain gray matter structure in relation to substance use severity among n = 152 high-risk, incarcerated boys (aged 14-20). Substance use severity was positively associated with gray matter volume across several frontal/striatal brain regions including amygdala, pallidum, putamen, insula, and orbitofrontal cortex. Effects were apparent when using voxel-based-morphometric analysis, as well as in whole-brain, data-driven, network-based approaches (source-based morphometry). These findings support the hypothesis that elevated gray matter volume in striatal reward circuits may be an endogenous marker for vulnerability to severe substance use behaviors among youth. En ligne : https://dx.doi.org/10.1017/S0954579424000804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Striatal brain volume linked to severity of substance use in high-risk incarcerated youth [Texte imprimé et/ou numérique] / Nathaniel E. ANDERSON, Auteur ; J. Michael MAURER, Auteur ; David STEPHENSON, Auteur ; Keith HARENSKI, Auteur ; Michael CALDWELL, Auteur ; Greg VAN RYBROEK, Auteur ; Kent A. KIEHL, Auteur . - p.966-975. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.966-975 Mots-clés : Antisocial behavior  MRI  brain volume  juvenile  substance use disorders Index. décimale : PER Périodiques Résumé : Substance use disorders among juveniles are a major public health concern and are often intertwined with other psychosocial risk factors including antisocial behavior. Identifying etiological risks and mechanisms promoting substance use disorders remains a high priority for informing more focused interventions in high-risk populations. The present study examined brain gray matter structure in relation to substance use severity among n = 152 high-risk, incarcerated boys (aged 14-20). Substance use severity was positively associated with gray matter volume across several frontal/striatal brain regions including amygdala, pallidum, putamen, insula, and orbitofrontal cortex. Effects were apparent when using voxel-based-morphometric analysis, as well as in whole-brain, data-driven, network-based approaches (source-based morphometry). These findings support the hypothesis that elevated gray matter volume in striatal reward circuits may be an endogenous marker for vulnerability to severe substance use behaviors among youth. En ligne : https://dx.doi.org/10.1017/S0954579424000804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

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