Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder / Andrew S. PERSICHETTI in Autism Research, 18-8 (August 2025)  

Public ISBD [article]  inAutism Research > 18-8 (August 2025) . - p.1563-1567 Titre : Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Andrew S. PERSICHETTI, Auteur ; Taylor L. LI, Auteur ; W. Dale STEVENS, Auteur ; Alex MARTIN, Auteur ; Adrian W. GILMORE, Auteur Article en page(s) : p.1563-1567 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional MRI  navigation  scene perception  spatial cognition Index. décimale : PER Périodiques Résumé : ABSTRACT A small behavioral literature on individuals with autism spectrum disorder (ASD) has shown that they can be impaired when navigating using map-based strategies (i.e., memory-guided navigation), but not during visually-guided navigation. Meanwhile, there is neuroimaging evidence in typically developing (TD) individuals demonstrating that the retrosplenial complex (RSC) is part of a memory-guided navigation system, while the occipital place area (OPA) is part of a visually-guided navigation system. A key identifying feature of the RSC and OPA is that they respond significantly more to pictures of places compared to faces or objects?i.e., they demonstrate scene-selectivity. Therefore, we predicted that scene-selectivity would be weaker in the RSC of individuals with ASD compared to a TD control group, while the OPA would not show such a difference between the groups. We used functional MRI to scan groups of ASD individuals and matched TD individuals while they viewed pictures of places and faces and performed a one-back task. As predicted, scene-selectivity was significantly lower in the RSC, but not OPA, in the ASD group compared to the TD group. These results suggest that impaired memory-guided navigation in individuals with ASD may, in part, be due to atypical functioning in the RSC. En ligne : https://doi.org/10.1002/aur.70079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Andrew S. PERSICHETTI, Auteur ; Taylor L. LI, Auteur ; W. Dale STEVENS, Auteur ; Alex MARTIN, Auteur ; Adrian W. GILMORE, Auteur . - p.1563-1567. Langues : Anglais (eng) in Autism Research > 18-8 (August 2025) . - p.1563-1567 Mots-clés : autism spectrum disorder  functional MRI  navigation  scene perception  spatial cognition Index. décimale : PER Périodiques Résumé : ABSTRACT A small behavioral literature on individuals with autism spectrum disorder (ASD) has shown that they can be impaired when navigating using map-based strategies (i.e., memory-guided navigation), but not during visually-guided navigation. Meanwhile, there is neuroimaging evidence in typically developing (TD) individuals demonstrating that the retrosplenial complex (RSC) is part of a memory-guided navigation system, while the occipital place area (OPA) is part of a visually-guided navigation system. A key identifying feature of the RSC and OPA is that they respond significantly more to pictures of places compared to faces or objects?i.e., they demonstrate scene-selectivity. Therefore, we predicted that scene-selectivity would be weaker in the RSC of individuals with ASD compared to a TD control group, while the OPA would not show such a difference between the groups. We used functional MRI to scan groups of ASD individuals and matched TD individuals while they viewed pictures of places and faces and performed a one-back task. As predicted, scene-selectivity was significantly lower in the RSC, but not OPA, in the ASD group compared to the TD group. These results suggest that impaired memory-guided navigation in individuals with ASD may, in part, be due to atypical functioning in the RSC. En ligne : https://doi.org/10.1002/aur.70079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

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