Upper airway obstruction with hypoxaemia and sleep disruption in Down syndrome / D. P. SOUTHALL in Developmental Medicine & Child Neurology, 29-6 (December 1987)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 29-6 (December 1987) . - p.734-742 Titre : Upper airway obstruction with hypoxaemia and sleep disruption in Down syndrome Type de document : Texte imprimé et/ou numérique Auteurs : D. P. SOUTHALL, Auteur ; V. A. STEBBENS, Auteur ; R. MIRZA, Auteur ; M. H. LANG, Auteur ; C. B. CROFT, Auteur ; E. A. SHINEBOURNE, Auteur Année de publication : 1987 Article en page(s) : p.734-742 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Six of 12 children with Down syndrome (DS) tested by means of long-term tape-recordings of oxygen saturation, breathing movements and expired CO2 were found to have previously undetected and severe upper airway obstruction during sleep. In five cases the obstruction occurred in the pharynx and in the sixth it was due to bilateral choanal stenosis. When compared with age-matched controls, overnight tape-recordings showed episodes of abnormal arterial hypoxaemia and an abnormally elevated end-tidal CO2. Episodes of obstruction were most marked during sleep associated with a non-regular breathing pattern. Abnormal episodes of hypoxaemia were associated with continued breathing movements. Sometimes there was no airflow (complete obstruction); at other times airflow continued normally or was reduced in amplitude (partial obstruction). During episodes of partial or complete airway obstruction the inspiratory waveform showed a characteristic shape. These results show sleep-related upper airway obstruction to be an often undetected complication of DS and all necessary measures should be taken to overcome the obstruction when it reaches the stage of producing abnormal hypoxaemia. Choanal dilatation and tracheostomy were successful in treating two of the children. Tonsillectomy and adenoidectomy were successful for one child, but only of marginal benefit for two others. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=630 [article] Upper airway obstruction with hypoxaemia and sleep disruption in Down syndrome [Texte imprimé et/ou numérique] / D. P. SOUTHALL, Auteur ; V. A. STEBBENS, Auteur ; R. MIRZA, Auteur ; M. H. LANG, Auteur ; C. B. CROFT, Auteur ; E. A. SHINEBOURNE, Auteur . - 1987 . - p.734-742. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 29-6 (December 1987) . - p.734-742 Index. décimale : PER Périodiques Résumé : Six of 12 children with Down syndrome (DS) tested by means of long-term tape-recordings of oxygen saturation, breathing movements and expired CO2 were found to have previously undetected and severe upper airway obstruction during sleep. In five cases the obstruction occurred in the pharynx and in the sixth it was due to bilateral choanal stenosis. When compared with age-matched controls, overnight tape-recordings showed episodes of abnormal arterial hypoxaemia and an abnormally elevated end-tidal CO2. Episodes of obstruction were most marked during sleep associated with a non-regular breathing pattern. Abnormal episodes of hypoxaemia were associated with continued breathing movements. Sometimes there was no airflow (complete obstruction); at other times airflow continued normally or was reduced in amplitude (partial obstruction). During episodes of partial or complete airway obstruction the inspiratory waveform showed a characteristic shape. These results show sleep-related upper airway obstruction to be an often undetected complication of DS and all necessary measures should be taken to overcome the obstruction when it reaches the stage of producing abnormal hypoxaemia. Choanal dilatation and tracheostomy were successful in treating two of the children. Tonsillectomy and adenoidectomy were successful for one child, but only of marginal benefit for two others. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=630

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