Research Review: What we have learned about the endocannabinoid system in developmental psychopathology / Ryann C. TANSEY in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1904-1915 Titre : Research Review: What we have learned about the endocannabinoid system in developmental psychopathology Type de document : texte imprimé Auteurs : Ryann C. TANSEY, Auteur ; Marc D. FERGER, Auteur ; Hilary A. MARUSAK, Auteur ; Leah M. MAYO, Auteur Article en page(s) : p.1904-1915 Langues : Anglais (eng) Mots-clés : Endocannabinoid  2-arachidonoylglycerol  anandamide  psychopathology  development Index. décimale : PER Périodiques Résumé : Background The endocannabinoid (eCB) system, the primary target of cannabis, has gained significant attention as a potential novel therapeutic approach for treating a range of psychiatric disorders characterized by dysregulation of stress, emotion, and social behavior. The use of cannabis itself as a pharmacotherapeutic in children and adolescents is limited due to various constraints, including legal status, stigma, and real or perceived negative side effects. Thus, compounds that target the eCB system without the notable unwanted effects of cannabis may offer a more viable approach for developing populations. Methods In this narrative review, we provide an overview of the eCB system, summarizing its function throughout development and its potential contribution to psychopathology in children and adolescents. We highlight evidence of its behavioral role and the dysregulation of this system in various psychiatric disorders. Finally, we summarize current investigations into pharmacological and nonpharmacological therapeutic interventions designed to target the eCB system. Conclusions The eCB system may offer an innovative target for treatments of various psychiatric disorders in child and adolescent populations. However, more research is needed to understand the nuanced developmental trajectory of this system and to determine whether existing compounds are safe and effective for use in these populations. En ligne : https://doi.org/10.1111/jcpp.70006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Research Review: What we have learned about the endocannabinoid system in developmental psychopathology [texte imprimé] / Ryann C. TANSEY, Auteur ; Marc D. FERGER, Auteur ; Hilary A. MARUSAK, Auteur ; Leah M. MAYO, Auteur . - p.1904-1915. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1904-1915 Mots-clés : Endocannabinoid  2-arachidonoylglycerol  anandamide  psychopathology  development Index. décimale : PER Périodiques Résumé : Background The endocannabinoid (eCB) system, the primary target of cannabis, has gained significant attention as a potential novel therapeutic approach for treating a range of psychiatric disorders characterized by dysregulation of stress, emotion, and social behavior. The use of cannabis itself as a pharmacotherapeutic in children and adolescents is limited due to various constraints, including legal status, stigma, and real or perceived negative side effects. Thus, compounds that target the eCB system without the notable unwanted effects of cannabis may offer a more viable approach for developing populations. Methods In this narrative review, we provide an overview of the eCB system, summarizing its function throughout development and its potential contribution to psychopathology in children and adolescents. We highlight evidence of its behavioral role and the dysregulation of this system in various psychiatric disorders. Finally, we summarize current investigations into pharmacological and nonpharmacological therapeutic interventions designed to target the eCB system. Conclusions The eCB system may offer an innovative target for treatments of various psychiatric disorders in child and adolescent populations. However, more research is needed to understand the nuanced developmental trajectory of this system and to determine whether existing compounds are safe and effective for use in these populations. En ligne : https://doi.org/10.1111/jcpp.70006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

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