[article] 
inAutism Research > 1-4 (August 2008) . - p.240-250

Titre :	Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Zohreh TALEBIZADEH, Auteur ; Merlin G. BUTLER, Auteur ; Mariana F. THEODORO, Auteur
Année de publication :	2008
Article en page(s) :	p.240-250
Langues :	Anglais (eng)
Mots-clés :	microRNA autism lymphoblastoid-cell-lines differential-expression
Index. décimale :	PER Périodiques
Résumé :	To assess the feasibility and relevance of using lymphoblastoid cell lines to study the role of noncoding RNAs in the etiology of autism, we evaluated global expression profiling of 470 mature human microRNAs from six subjects with autism compared with six matched controls. Differential expression (either higher or lower) for 9 of the 470 microRNAs was observed in our autism samples compared with controls. Potential target genes for these microRNAs were identified using computer tools, which included several autism susceptibility genes. Our preliminary results indicate microRNAs should be considered and evaluated in the etiology of autism. In addition, analysis of this class of noncoding RNAs in lymphoblastoid cells has the potential to reveal at least a subset of brain-related microRNAs implicated in autism. Subsequently, this model system should allow for detection of complex subtle changes in susceptibility genes/pathways contributing to autism.
En ligne :	http://dx.doi.org/10.1002/aur.33
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932

[article] Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism [Texte imprimé et/ou numérique] / Zohreh TALEBIZADEH, Auteur ; Merlin G. BUTLER, Auteur ; Mariana F. THEODORO, Auteur . - 2008 . - p.240-250.
Langues : Anglais (eng)
in Autism Research > 1-4 (August 2008) . - p.240-250

Mots-clés :	microRNA autism lymphoblastoid-cell-lines differential-expression
Index. décimale :	PER Périodiques
Résumé :	To assess the feasibility and relevance of using lymphoblastoid cell lines to study the role of noncoding RNAs in the etiology of autism, we evaluated global expression profiling of 470 mature human microRNAs from six subjects with autism compared with six matched controls. Differential expression (either higher or lower) for 9 of the 470 microRNAs was observed in our autism samples compared with controls. Potential target genes for these microRNAs were identified using computer tools, which included several autism susceptibility genes. Our preliminary results indicate microRNAs should be considered and evaluated in the etiology of autism. In addition, analysis of this class of noncoding RNAs in lymphoblastoid cells has the potential to reveal at least a subset of brain-related microRNAs implicated in autism. Subsequently, this model system should allow for detection of complex subtle changes in susceptibility genes/pathways contributing to autism.
En ligne :	http://dx.doi.org/10.1002/aur.33
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932