Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse / Sophie TOWNEND in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.211-225 Titre : Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse Type de document : texte imprimé Auteurs : Sophie TOWNEND, Auteur ; Marlene STAGINNUS, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Anne MARTINELLI, Auteur ; Anka BERNHARD, Auteur ; Nora Maria RASCHLE, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Christina STADLER, Auteur ; Christine M. FREITAG, Auteur ; Esther WALTON, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur Article en page(s) : p.211-225 Langues : Anglais (eng) Mots-clés : antisocial behavior child abuse childhood maltreatment conduct disorder diffusion tensor imaging sex differences Index. décimale : PER Périodiques Résumé : Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies. En ligne : https://dx.doi.org/10.1017/S0954579425000367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse [texte imprimé] / Sophie TOWNEND, Auteur ; Marlene STAGINNUS, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Anne MARTINELLI, Auteur ; Anka BERNHARD, Auteur ; Nora Maria RASCHLE, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Christina STADLER, Auteur ; Christine M. FREITAG, Auteur ; Esther WALTON, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur . - p.211-225. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.211-225 Mots-clés : antisocial behavior child abuse childhood maltreatment conduct disorder diffusion tensor imaging sex differences Index. décimale : PER Périodiques Résumé : Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies. En ligne : https://dx.doi.org/10.1017/S0954579425000367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

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