Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder / Kari L. HANSON in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) Titre : Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder Type de document : texte imprimé Auteurs : Kari L. HANSON, Auteur ; Thomas AVINO, Auteur ; Sandra L. TAYLOR, Auteur ; Karl D. MURRAY, Auteur ; Cynthia M. SCHUMANN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neuronal connectivity is refined throughout development by the proliferation and pruning of axons in cerebral white matter, and progressive axon myelination that enables rapid communication across brain regions. Differences in connectivity have been observed in autism spectrum disorder (ASD), including changes in white matter volume and connectivity. In the prefrontal cortex, this includes imbalances between short- and long-ranging axons, consistent with a pattern of local hyperconnectivity, and long-range hypoconnectivity. Alterations in temporal lobe white matter development—critical for social behavior—may contribute to atypical neural connectivity. En ligne : https://doi.org/10.1186/s13229-025-00684-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder [texte imprimé] / Kari L. HANSON, Auteur ; Thomas AVINO, Auteur ; Sandra L. TAYLOR, Auteur ; Karl D. MURRAY, Auteur ; Cynthia M. SCHUMANN, Auteur. Langues : Anglais (eng) in Molecular Autism > 16 (2025) Index. décimale : PER Périodiques Résumé : Neuronal connectivity is refined throughout development by the proliferation and pruning of axons in cerebral white matter, and progressive axon myelination that enables rapid communication across brain regions. Differences in connectivity have been observed in autism spectrum disorder (ASD), including changes in white matter volume and connectivity. In the prefrontal cortex, this includes imbalances between short- and long-ranging axons, consistent with a pattern of local hyperconnectivity, and long-range hypoconnectivity. Alterations in temporal lobe white matter development—critical for social behavior—may contribute to atypical neural connectivity. En ligne : https://doi.org/10.1186/s13229-025-00684-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

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