Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models / Evangelia POLLALI in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) Titre : Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models Type de document : texte imprimé Auteurs : Evangelia POLLALI, Auteur ; Daniel Frías DONAIRE, Auteur ; Miguel Del ÁNGEL, Auteur ; Yunus Emre DEMIRAY, Auteur ; Sara Enrile LACALLE, Auteur ; Jan-Oliver HOLLNAGEL, Auteur ; Anil ANNAMNEEDI, Auteur ; Gürsel ÇALıŞKAN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common inherited intellectual disability, caused by the loss of fragile X mental retardation protein (FMRP), which regulates neuronal signaling and plasticity. FXS patients and Fmr1 knockout (KO) mice exhibit sensory hypersensitivity, hyperarousal, and hippocampus-dependent learning deficits. Dysregulated metabotropic glutamate receptor (mGluR) and muscarinic acetylcholine receptor (mAChR) signaling, along with reduced kainate receptor (KAR) function, have been implicated in FXS pathophysiology. Activation of these signaling pathways induce gamma-frequency network oscillations hippocampal slices in vitro. However, their specific contribution to aberrant gamma oscillations in FXS remains unclear. En ligne : https://doi.org/10.1186/s13229-025-00687-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models [texte imprimé] / Evangelia POLLALI, Auteur ; Daniel Frías DONAIRE, Auteur ; Miguel Del ÁNGEL, Auteur ; Yunus Emre DEMIRAY, Auteur ; Sara Enrile LACALLE, Auteur ; Jan-Oliver HOLLNAGEL, Auteur ; Anil ANNAMNEEDI, Auteur ; Gürsel ÇALıŞKAN, Auteur. Langues : Anglais (eng) in Molecular Autism > 16 (2025) Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common inherited intellectual disability, caused by the loss of fragile X mental retardation protein (FMRP), which regulates neuronal signaling and plasticity. FXS patients and Fmr1 knockout (KO) mice exhibit sensory hypersensitivity, hyperarousal, and hippocampus-dependent learning deficits. Dysregulated metabotropic glutamate receptor (mGluR) and muscarinic acetylcholine receptor (mAChR) signaling, along with reduced kainate receptor (KAR) function, have been implicated in FXS pathophysiology. Activation of these signaling pathways induce gamma-frequency network oscillations hippocampal slices in vitro. However, their specific contribution to aberrant gamma oscillations in FXS remains unclear. En ligne : https://doi.org/10.1186/s13229-025-00687-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

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