UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome / Xin YANG in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) Titre : UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome Type de document : texte imprimé Auteurs : Xin YANG, Auteur ; Yuwen-Alvin HUANG, Auteur ; John MARSHALL, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Ubiquitin protein ligase E3A (UBE3A) regulates signaling pathways associated with autism spectrum disorders (ASDs). As an E3 ligase, UBE3A ubiquitinates and promotes the degradation of proteins crucial for regulating synaptic plasticity and learning. Loss-of-function mutations in UBE3A result in Angelman Syndrome, while gain-of-function or duplications contribute to ASDs and Dup15q Syndrome. En ligne : https://doi.org/10.1186/s13229-025-00690-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome [texte imprimé] / Xin YANG, Auteur ; Yuwen-Alvin HUANG, Auteur ; John MARSHALL, Auteur. Langues : Anglais (eng) in Molecular Autism > 16 (2025) Index. décimale : PER Périodiques Résumé : Ubiquitin protein ligase E3A (UBE3A) regulates signaling pathways associated with autism spectrum disorders (ASDs). As an E3 ligase, UBE3A ubiquitinates and promotes the degradation of proteins crucial for regulating synaptic plasticity and learning. Loss-of-function mutations in UBE3A result in Angelman Syndrome, while gain-of-function or duplications contribute to ASDs and Dup15q Syndrome. En ligne : https://doi.org/10.1186/s13229-025-00690-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

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