Analyzing direct and indirect genetic effects on early neurodevelopmental traits – a commentary on Hegemann et al / Yalan LI in Journal of Child Psychology and Psychiatry, 67-6 (June 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.998-1000 Titre : Analyzing direct and indirect genetic effects on early neurodevelopmental traits – a commentary on Hegemann et al Type de document : texte imprimé Auteurs : Yalan LI, Auteur ; Tianjiao LIU, Auteur ; Xin LI, Auteur Article en page(s) : p.998-1000 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The study by Hegemann et al. advances understanding of the genetic architecture underlying early neurodevelopmental traits by distinguishing direct and indirect genetic effects using Trio-GCTA and polygenic score models. Findings reveal that indirect genetic effects are particularly pronounced for hyperactivity and restricted and repetitive behaviors, while direct effects dominate in language and motor development. Notably, associations between parental cognitive and educational attainment polygenic scores and child outcomes suggest potential protective genetic influences. However, several methodological considerations may affect interpretation. Excluding closely related individuals could limit the detection of extended familial effects, and reliance on polygenic scores derived from predominantly European GWAS may constrain generalizability. Furthermore, current PGS explain only a portion of trait heritability, possibly underrepresenting true genetic contributions. Future studies incorporating extended family structures, diverse populations, and alternative methods to model gene?environment interplay are essential for refining insights into early neurodevelopmental processes. En ligne : https://doi.org/10.1111/jcpp.70070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] Analyzing direct and indirect genetic effects on early neurodevelopmental traits – a commentary on Hegemann et al [texte imprimé] / Yalan LI, Auteur ; Tianjiao LIU, Auteur ; Xin LI, Auteur . - p.998-1000. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.998-1000 Index. décimale : PER Périodiques Résumé : The study by Hegemann et al. advances understanding of the genetic architecture underlying early neurodevelopmental traits by distinguishing direct and indirect genetic effects using Trio-GCTA and polygenic score models. Findings reveal that indirect genetic effects are particularly pronounced for hyperactivity and restricted and repetitive behaviors, while direct effects dominate in language and motor development. Notably, associations between parental cognitive and educational attainment polygenic scores and child outcomes suggest potential protective genetic influences. However, several methodological considerations may affect interpretation. Excluding closely related individuals could limit the detection of extended familial effects, and reliance on polygenic scores derived from predominantly European GWAS may constrain generalizability. Furthermore, current PGS explain only a portion of trait heritability, possibly underrepresenting true genetic contributions. Future studies incorporating extended family structures, diverse populations, and alternative methods to model gene?environment interplay are essential for refining insights into early neurodevelopmental processes. En ligne : https://doi.org/10.1111/jcpp.70070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

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