Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 – 2021 National Survey of Children’s Health / Qianyi XIE in Journal of Autism and Developmental Disorders, 56-10 (October 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-10 (October 2026) . - p. 4010-4024 Titre : Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 – 2021 National Survey of Children’s Health Type de document : texte imprimé Auteurs : Qianyi XIE, Auteur ; Ning PAN, Auteur ; Xiaoxuan OU, Auteur ; Shuli SHEN, Auteur ; Jin JING, Auteur ; Xuchu WENG, Auteur ; Lei SHI, Auteur ; Lizi LIN, Auteur ; Jiaze YANG, Auteur ; Xiangpeng LI, Auteur ; Kai ZHANG, Auteur ; Fangfang CHEN, Auteur ; Yujie WANG, Auteur ; Jinqing WU, Auteur ; Xin WANG, Auteur Article en page(s) : p. 4010-4024 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) have long been reported to exhibit atypical pain experiences. Chronic physical pain is a significant comorbidity in ASD, leading to substantial burdens on daily functioning and quality of life. This study aims to examine the potential associations between ASD and chronic physical pain, including its specific types. The study used data on chronic physical pain and headaches from the 2016 – 2021 National Survey of Children’s Health. Participants were children aged 3 to 17 years old. Generalized linear models were used to estimate the associations between ASD and pain-related indicators (e.g., chronic physical pain, headaches, and other back or body pain). The study included 177,539 children, of whom 5311 had a current ASD diagnosis. Among children with current ASD, 14.41% experienced chronic physical pain, with 4.86% reporting headaches and 9.56% reporting other back or body pain. Compared to those without, children with current ASD had higher odds of chronic physical pain [odds ratio (OR) = 1.76, 95% confidence interval (CI): 1.40 – 2.21]. Notably, the odds of headaches (OR = 1.78, 95% CI: 1.33 – 2.38) were higher than the odds of other back or body pain (OR = 1.62, 95% CI: 1.20 – 2.19). Children with current ASD were more likely to experience chronic physical pain than those without. This trend is more pronounced in headaches compared to other back or body pain. Our findings highlight the importance of prioritizing pain management in children with ASD through thorough physical assessments. En ligne : https://doi.org/10.1007/s10803-025-06846-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 – 2021 National Survey of Children’s Health [texte imprimé] / Qianyi XIE, Auteur ; Ning PAN, Auteur ; Xiaoxuan OU, Auteur ; Shuli SHEN, Auteur ; Jin JING, Auteur ; Xuchu WENG, Auteur ; Lei SHI, Auteur ; Lizi LIN, Auteur ; Jiaze YANG, Auteur ; Xiangpeng LI, Auteur ; Kai ZHANG, Auteur ; Fangfang CHEN, Auteur ; Yujie WANG, Auteur ; Jinqing WU, Auteur ; Xin WANG, Auteur . - p. 4010-4024. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-10 (October 2026) . - p. 4010-4024 Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) have long been reported to exhibit atypical pain experiences. Chronic physical pain is a significant comorbidity in ASD, leading to substantial burdens on daily functioning and quality of life. This study aims to examine the potential associations between ASD and chronic physical pain, including its specific types. The study used data on chronic physical pain and headaches from the 2016 – 2021 National Survey of Children’s Health. Participants were children aged 3 to 17 years old. Generalized linear models were used to estimate the associations between ASD and pain-related indicators (e.g., chronic physical pain, headaches, and other back or body pain). The study included 177,539 children, of whom 5311 had a current ASD diagnosis. Among children with current ASD, 14.41% experienced chronic physical pain, with 4.86% reporting headaches and 9.56% reporting other back or body pain. Compared to those without, children with current ASD had higher odds of chronic physical pain [odds ratio (OR) = 1.76, 95% confidence interval (CI): 1.40 – 2.21]. Notably, the odds of headaches (OR = 1.78, 95% CI: 1.33 – 2.38) were higher than the odds of other back or body pain (OR = 1.62, 95% CI: 1.20 – 2.19). Children with current ASD were more likely to experience chronic physical pain than those without. This trend is more pronounced in headaches compared to other back or body pain. Our findings highlight the importance of prioritizing pain management in children with ASD through thorough physical assessments. En ligne : https://doi.org/10.1007/s10803-025-06846-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice / Krisztina SÁFÁR in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70286 Titre : Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice Type de document : texte imprimé Auteurs : Krisztina SÁFÁR, Auteur ; Vivien SZENDI, Auteur ; Paulina HOPPA, Auteur ; Yutong WANG, Auteur ; Fanni Á SERES, Auteur ; Szilvia BARTÓK, Auteur ; Tyler TEADORA, Auteur ; Lei SHI, Auteur ; Árpád DOBOLYI, Auteur ; Gina PUSKA, Auteur ; István ADORJÁN, Auteur Article en page(s) : p.e70286 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  calretinin  CNTNAP2  parvalbumin  social behavior  social novelty preference  striatum Index. décimale : PER Périodiques Résumé : ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown. Interneurons, as key regulators of excitatory?inhibitory balance, represent a candidate source of vulnerability. In this study, we quantified calretinin-positive (CR+) and parvalbumin-positive (PV+) interneuron density in the caudoputamen (CP) and somatosensory cortex (SSC) of Cntnap2 knockout (KO) and wild-type (WT) mice and assessed their relationship with social behavior. Cntnap2 KO mice exhibited significantly lower CR+ interneuron density in both brain regions, whereas no significant difference was observed in the PV+ density. Cntnap2 KO females showed altered behavior in the social novelty preference test compared to WT females. Cntnap2 KO animals also displayed elevated ?moving away? responses, a social withdrawal phenotype. Correlation analyses revealed that within the KO group, higher striatal CR+ density was associated with a greater frequency and duration of ?moving away.? CR+ density in the SSC did not correlate with this behavioral phenotype. The results suggest that striatal CR+ interneurons may modulate the persistence and intensity of social withdrawal behavior. In conclusion, our findings reveal region-specific alterations in CR+ interneuron density in Cntnap2 KO mice and uncover a previously unrecognized link between Cntnap2 function, striatal interneuron organization and social withdrawal behavior. The results highlight CR+ interneurons as potential contributors to altered basal ganglia function in ASD and underscore the need for circuit-level analyses of genetically defined risk models. En ligne : https://doi.org/10.1002/aur.70286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice [texte imprimé] / Krisztina SÁFÁR, Auteur ; Vivien SZENDI, Auteur ; Paulina HOPPA, Auteur ; Yutong WANG, Auteur ; Fanni Á SERES, Auteur ; Szilvia BARTÓK, Auteur ; Tyler TEADORA, Auteur ; Lei SHI, Auteur ; Árpád DOBOLYI, Auteur ; Gina PUSKA, Auteur ; István ADORJÁN, Auteur . - p.e70286. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70286 Mots-clés : autism spectrum disorder  calretinin  CNTNAP2  parvalbumin  social behavior  social novelty preference  striatum Index. décimale : PER Périodiques Résumé : ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown. Interneurons, as key regulators of excitatory?inhibitory balance, represent a candidate source of vulnerability. In this study, we quantified calretinin-positive (CR+) and parvalbumin-positive (PV+) interneuron density in the caudoputamen (CP) and somatosensory cortex (SSC) of Cntnap2 knockout (KO) and wild-type (WT) mice and assessed their relationship with social behavior. Cntnap2 KO mice exhibited significantly lower CR+ interneuron density in both brain regions, whereas no significant difference was observed in the PV+ density. Cntnap2 KO females showed altered behavior in the social novelty preference test compared to WT females. Cntnap2 KO animals also displayed elevated ?moving away? responses, a social withdrawal phenotype. Correlation analyses revealed that within the KO group, higher striatal CR+ density was associated with a greater frequency and duration of ?moving away.? CR+ density in the SSC did not correlate with this behavioral phenotype. The results suggest that striatal CR+ interneurons may modulate the persistence and intensity of social withdrawal behavior. In conclusion, our findings reveal region-specific alterations in CR+ interneuron density in Cntnap2 KO mice and uncover a previously unrecognized link between Cntnap2 function, striatal interneuron organization and social withdrawal behavior. The results highlight CR+ interneurons as potential contributors to altered basal ganglia function in ASD and underscore the need for circuit-level analyses of genetically defined risk models. En ligne : https://doi.org/10.1002/aur.70286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

---

1 (1 - 2 / 2) Par page : 25 50 100 200