Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene–environment interplay with family conflict and parental acceptance / Belal JAMIL in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1120-1137 Titre : Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene–environment interplay with family conflict and parental acceptance Type de document : texte imprimé Auteurs : Belal JAMIL, Auteur ; Jinni SU, Auteur ; Kit ELAM, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Rick CRUZ, Auteur ; Kevin GRIMM, Auteur ; Eleanor SEATON, Auteur Article en page(s) : p.1120-1137 Langues : Anglais (eng) Mots-clés : adolescent depressive symptoms  family conflict  gene-environment interplay  parental acceptance  polygenic risk score Index. décimale : PER Périodiques Résumé : Introduction:Past research suggests that polygenic scores for major depressive disorder (MDD-PGS), family conflict, and parental acceptance may all predict depressive outcomes among adolescents. Few studies have examined the interplay of these factors through gene–environment interaction (GxE) and gene–environment correlation (rGE) in racially/ethnically diverse samples of adolescents. Methods: Utilizing latent curve analysis and growth mixture modeling in a diverse sample of 10,771 adolescents from the Adolescent Brain and Cognitive Development (ABCD) study, the present study examined how MDD-PGS, family conflict, and parental acceptance predicted depressive trajectory class membership through GxE and rGE in independent models for Black, Latinx, and White adolescents. Results: Among all youth, MDD-PGS and family conflict were associated with greater intercept-levels of depressive symptoms. Among Latinx and White youth, parental acceptance was associated with lower intercept levels of depressive symptoms. MDD-PGS (among all youth), lower parental acceptance (among Latinx and White youth), and greater family conflict (among White youth) increased odds of higher-risk trajectories. Evidence of rGE through family conflict was found among White youth. No evidence of GxE was found. Conclusion: Our findings highlight utility of MDD-PGS and the need to expand conceptualizations of environment to identify salient supportive and stressful experiences across racially/ethnically diverse youth. En ligne : https://dx.doi.org/10.1017/S0954579425101028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene–environment interplay with family conflict and parental acceptance [texte imprimé] / Belal JAMIL, Auteur ; Jinni SU, Auteur ; Kit ELAM, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Rick CRUZ, Auteur ; Kevin GRIMM, Auteur ; Eleanor SEATON, Auteur . - p.1120-1137. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1120-1137 Mots-clés : adolescent depressive symptoms  family conflict  gene-environment interplay  parental acceptance  polygenic risk score Index. décimale : PER Périodiques Résumé : Introduction:Past research suggests that polygenic scores for major depressive disorder (MDD-PGS), family conflict, and parental acceptance may all predict depressive outcomes among adolescents. Few studies have examined the interplay of these factors through gene–environment interaction (GxE) and gene–environment correlation (rGE) in racially/ethnically diverse samples of adolescents. Methods: Utilizing latent curve analysis and growth mixture modeling in a diverse sample of 10,771 adolescents from the Adolescent Brain and Cognitive Development (ABCD) study, the present study examined how MDD-PGS, family conflict, and parental acceptance predicted depressive trajectory class membership through GxE and rGE in independent models for Black, Latinx, and White adolescents. Results: Among all youth, MDD-PGS and family conflict were associated with greater intercept-levels of depressive symptoms. Among Latinx and White youth, parental acceptance was associated with lower intercept levels of depressive symptoms. MDD-PGS (among all youth), lower parental acceptance (among Latinx and White youth), and greater family conflict (among White youth) increased odds of higher-risk trajectories. Evidence of rGE through family conflict was found among White youth. No evidence of GxE was found. Conclusion: Our findings highlight utility of MDD-PGS and the need to expand conceptualizations of environment to identify salient supportive and stressful experiences across racially/ethnically diverse youth. En ligne : https://dx.doi.org/10.1017/S0954579425101028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

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