The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis / Kirsten FURLEY in Journal of Autism and Developmental Disorders, 56-7 (July 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-7 (July 2026) . - p.2721-2734 Titre : The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Kirsten FURLEY, Auteur ; Audrey TEO, Auteur ; Katrina WILLIAMS, Auteur ; Mohammed ALSHAWSH, Auteur ; Amanda BRIGNELL, Auteur Article en page(s) : p.2721-2734 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This systematic review evaluates the diagnostic yield of investigations requested for children with developmental regression. Online databases MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane were searched to identify published records that reported a diagnostic yield for children with developmental regression. Random effects meta-analyses were performed using R software with meta package. Our search identified 11,283 published records, of which 347 were assessed for eligibility, and 15 (596 children) were included in the final systematic review and meta-analysis. Subgroup analysis assessed the diagnostic yield for investigating children with different presentations and developmental regression. Diagnostic yield results were 68% for children with neurological symptoms (two records, six children, 95%CI 32–100) and children with epileptic symptoms (two records, 56 children, 95%CI 15–100); 40% for children with neurodevelopmental delay (six records, 294 children, 95%CI 3–78); 9% for autistic children (three records, 138 children, 95%CI 0–26). Pooled analysis could not be completed for metabolic (one record, 29 children) or genetic presentations (one record, 73 children). The diagnostic yield for genetic/genomic investigations (six records, 142 children, 95%CI, 47–92) was 70%, compared with 28% for metabolic (five records, 286 children, 95%CI 0–64), 13% for neurophysiological (two records, 127 children, 95%CI 0–39) and 6% for neuroimaging (two records, 41 children, 95%CI 0–20). Investigations for children with developmental regression and neurological or epileptic symptoms resulted in the highest diagnostic yield. These results are clinically meaningful and will inform future research to advance towards an agreed investigative approach yet lack statistical significance due to small samples. En ligne : https://doi.org/10.1007/s10803-025-06749-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis [texte imprimé] / Kirsten FURLEY, Auteur ; Audrey TEO, Auteur ; Katrina WILLIAMS, Auteur ; Mohammed ALSHAWSH, Auteur ; Amanda BRIGNELL, Auteur . - p.2721-2734. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-7 (July 2026) . - p.2721-2734 Index. décimale : PER Périodiques Résumé : This systematic review evaluates the diagnostic yield of investigations requested for children with developmental regression. Online databases MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane were searched to identify published records that reported a diagnostic yield for children with developmental regression. Random effects meta-analyses were performed using R software with meta package. Our search identified 11,283 published records, of which 347 were assessed for eligibility, and 15 (596 children) were included in the final systematic review and meta-analysis. Subgroup analysis assessed the diagnostic yield for investigating children with different presentations and developmental regression. Diagnostic yield results were 68% for children with neurological symptoms (two records, six children, 95%CI 32–100) and children with epileptic symptoms (two records, 56 children, 95%CI 15–100); 40% for children with neurodevelopmental delay (six records, 294 children, 95%CI 3–78); 9% for autistic children (three records, 138 children, 95%CI 0–26). Pooled analysis could not be completed for metabolic (one record, 29 children) or genetic presentations (one record, 73 children). The diagnostic yield for genetic/genomic investigations (six records, 142 children, 95%CI, 47–92) was 70%, compared with 28% for metabolic (five records, 286 children, 95%CI 0–64), 13% for neurophysiological (two records, 127 children, 95%CI 0–39) and 6% for neuroimaging (two records, 41 children, 95%CI 0–20). Investigations for children with developmental regression and neurological or epileptic symptoms resulted in the highest diagnostic yield. These results are clinically meaningful and will inform future research to advance towards an agreed investigative approach yet lack statistical significance due to small samples. En ligne : https://doi.org/10.1007/s10803-025-06749-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

The Meaning of Autism Friendly in Hospital Settings: A Scoping Review of the Autism Community’s Perspectives / Sarah C G DAVENPORT in Journal of Autism and Developmental Disorders, 56-8 (August 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-8 (August 2026) . - p.3055-3070 Titre : The Meaning of Autism Friendly in Hospital Settings: A Scoping Review of the Autism Community’s Perspectives Type de document : texte imprimé Auteurs : Sarah C G DAVENPORT, Auteur ; Mohammed ALSHAWSH, Auteur ; Cameron LEE, Auteur ; Alice GARRICK, Auteur ; Amanda BRIGNELL, Auteur ; Alexandra URE, Auteur ; Beth P JOHNSON, Auteur Article en page(s) : p.3055-3070 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Hospitals are motivated to create more autism friendly environments to optimise access and experience for the community. However, there is a lack of clarity in what the term autism friendly in hospital settings means. We conducted a scoping review of four online databases and eleven national autism organisations to determine existing definitions for autism friendly within hospital settings. To operationalise the meaning of autism friendly hospital care, we then reviewed barriers and facilitators to hospital care from the perspective of autistic patients. Within the seven studies that considered the meaning of autism friendly, we found that the term autism friendly within a hospital context is undefined. To operationalise the meaning of autism friendly within hospitals, we identified barriers and facilitators in 16 studies that examined the hospital experience of autistic patients. We identified 19 facilitators and 23 barriers across three categories: people, place, and time. Flexibility underpinned the three categories, with flexible people, flexible place, and flexible timing reported as being integral to improving the hospital experience of patients with autism. Our findings provide clear guidance for creating autism friendly hospital care. En ligne : https://doi.org/10.1007/s10803-025-06781-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] The Meaning of Autism Friendly in Hospital Settings: A Scoping Review of the Autism Community’s Perspectives [texte imprimé] / Sarah C G DAVENPORT, Auteur ; Mohammed ALSHAWSH, Auteur ; Cameron LEE, Auteur ; Alice GARRICK, Auteur ; Amanda BRIGNELL, Auteur ; Alexandra URE, Auteur ; Beth P JOHNSON, Auteur . - p.3055-3070. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-8 (August 2026) . - p.3055-3070 Index. décimale : PER Périodiques Résumé : Hospitals are motivated to create more autism friendly environments to optimise access and experience for the community. However, there is a lack of clarity in what the term autism friendly in hospital settings means. We conducted a scoping review of four online databases and eleven national autism organisations to determine existing definitions for autism friendly within hospital settings. To operationalise the meaning of autism friendly hospital care, we then reviewed barriers and facilitators to hospital care from the perspective of autistic patients. Within the seven studies that considered the meaning of autism friendly, we found that the term autism friendly within a hospital context is undefined. To operationalise the meaning of autism friendly within hospitals, we identified barriers and facilitators in 16 studies that examined the hospital experience of autistic patients. We identified 19 facilitators and 23 barriers across three categories: people, place, and time. Flexibility underpinned the three categories, with flexible people, flexible place, and flexible timing reported as being integral to improving the hospital experience of patients with autism. Our findings provide clear guidance for creating autism friendly hospital care. En ligne : https://doi.org/10.1007/s10803-025-06781-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

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