Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population-Based Cohort Study / Vincent Chin-Hung CHEN in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70302 Titre : Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population-Based Cohort Study Type de document : texte imprimé Auteurs : Vincent Chin-Hung CHEN, Auteur ; Yu-Hsin HUANG, Auteur ; Yi-Lung CHEN, Auteur ; Michael E. DEWEY, Auteur ; Tai-Hsin HUNG, Auteur ; Shu- I. WU, Auteur Article en page(s) : p. e70302 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) often experience premature mortality and co-occurring psychiatric conditions, for which antidepressants are commonly prescribed. However, the long-term safety of antidepressant use in this population remains unclear. Using data from the Taiwan National Health Insurance Research Database, we emulated a target trial to examine the association between antidepressant use and mortality among individuals with ASD aged 6?64?years diagnosed between 2000 and 2016. A three-step approach of cloning, censoring, and inverse probability of censoring weighting was applied to address immortal-time bias. Participants were followed for up to 5?years to assess all-cause, suicide, and accidental-cause mortality. Among 33,939 eligible individuals, 779 initiated antidepressants within a 3-month grace period. Antidepressant use was not associated with all-cause or suicide mortality overall. However, it was significantly associated with reduced accidental-cause mortality at both 2 (HR?=?0.15; 95% CI, 0.04?0.53) and 5?years (HR?=?0.05; 95% CI, 0.01?0.20). Subgroup analysis revealed increased 2-year all-cause mortality among youths (HR?=?4.40; 95% CI, 1.10?17.58) but significantly decreased 5-year accidental mortality in the age groups of 6?15?years (HR?=?0.06; 95% CI, 0.01?0.41) and over 24?years (HR?=?0.06; 95% CI, 0.01?0.42). Additionally, decreased 5-year suicide mortality was observed in the 16?24 age group (HR?=?0.17; 95% CI, 0.05?0.61). While antidepressant use may reduce accidental mortality in individuals with ASD, age-specific risks warrant careful consideration and monitoring, particularly among younger populations. En ligne : https://doi.org/10.1002/aur.70302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population-Based Cohort Study [texte imprimé] / Vincent Chin-Hung CHEN, Auteur ; Yu-Hsin HUANG, Auteur ; Yi-Lung CHEN, Auteur ; Michael E. DEWEY, Auteur ; Tai-Hsin HUNG, Auteur ; Shu- I. WU, Auteur . - p. e70302. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70302 Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) often experience premature mortality and co-occurring psychiatric conditions, for which antidepressants are commonly prescribed. However, the long-term safety of antidepressant use in this population remains unclear. Using data from the Taiwan National Health Insurance Research Database, we emulated a target trial to examine the association between antidepressant use and mortality among individuals with ASD aged 6?64?years diagnosed between 2000 and 2016. A three-step approach of cloning, censoring, and inverse probability of censoring weighting was applied to address immortal-time bias. Participants were followed for up to 5?years to assess all-cause, suicide, and accidental-cause mortality. Among 33,939 eligible individuals, 779 initiated antidepressants within a 3-month grace period. Antidepressant use was not associated with all-cause or suicide mortality overall. However, it was significantly associated with reduced accidental-cause mortality at both 2 (HR?=?0.15; 95% CI, 0.04?0.53) and 5?years (HR?=?0.05; 95% CI, 0.01?0.20). Subgroup analysis revealed increased 2-year all-cause mortality among youths (HR?=?4.40; 95% CI, 1.10?17.58) but significantly decreased 5-year accidental mortality in the age groups of 6?15?years (HR?=?0.06; 95% CI, 0.01?0.41) and over 24?years (HR?=?0.06; 95% CI, 0.01?0.42). Additionally, decreased 5-year suicide mortality was observed in the 16?24 age group (HR?=?0.17; 95% CI, 0.05?0.61). While antidepressant use may reduce accidental mortality in individuals with ASD, age-specific risks warrant careful consideration and monitoring, particularly among younger populations. En ligne : https://doi.org/10.1002/aur.70302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

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