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Auteur William G. IACONO |
Documents disponibles écrits par cet auteur (24)
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Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? / Sylia WILSON in Development and Psychopathology, 26-4 (Part 2) (November 2014)
[article]
Titre : Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? Type de document : Texte imprimé et/ou numérique Auteurs : Sylia WILSON, Auteur ; Uma VAIDYANATHAN, Auteur ; Michael B. MILLER, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur Année de publication : 2014 Article en page(s) : p.1477-1493 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age 11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent–child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual single nucleotide polymorphism based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset. En ligne : http://dx.doi.org/10.1017/S0954579414001151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245
in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1477-1493[article] Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? [Texte imprimé et/ou numérique] / Sylia WILSON, Auteur ; Uma VAIDYANATHAN, Auteur ; Michael B. MILLER, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur . - 2014 . - p.1477-1493.
Langues : Anglais (eng)
in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1477-1493
Index. décimale : PER Périodiques Résumé : Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age 11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent–child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual single nucleotide polymorphism based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset. En ligne : http://dx.doi.org/10.1017/S0954579414001151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 Pubertal timing and adolescent outcomes: investigating explanations for associations with a genetically informed design / Emily R. PADRUTT in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)
[article]
Titre : Pubertal timing and adolescent outcomes: investigating explanations for associations with a genetically informed design Type de document : Texte imprimé et/ou numérique Auteurs : Emily R. PADRUTT, Auteur ; Jeremy HARPER, Auteur ; Jonathan D. SCHAEFER, Auteur ; Kayla M. NELSON, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Sylia WILSON, Auteur Article en page(s) : p.1232-1241 Langues : Anglais (eng) Mots-clés : Pubertal timing substance use risky behavior peer problems psychopathology Index. décimale : PER Périodiques Résumé : Background Psychopathology and risky behaviors increase during adolescence, and understanding which adolescents are most at risk informs prevention and intervention efforts. Pubertal timing relative to same-sex, same-age peers is a known correlate of adolescent outcomes among both boys and girls. However, it remains unclear whether this relation is better explained by a plausible causal process or unobserved familial liability. Methods We extended previous research by examining associations between pubertal timing in early adolescence (age 14) and outcomes in later adolescence (age 17) in a community sample of 2,510 twins (49% boys, 51% girls). Results Earlier pubertal timing was associated with more substance use, risk behavior, internalizing and externalizing problems, and peer problems in later adolescence; these effects were small, consistent with previous literature. Follow-up co-twin control analyses indicated that within-twin-pair differences in pubertal timing were not associated with within-twin-pair differences in most adolescent outcomes after accounting for shared familial liability, suggesting that earlier pubertal timing and adolescent outcomes both reflect familial risk factors. Biometric models indicated that associations between earlier pubertal timing and negative adolescent outcomes were largely attributable to shared genetic liability. Conclusions Although earlier pubertal timing was associated with negative adolescent outcomes, our results suggests that these associations did not appear to be caused by earlier pubertal timing but were likely caused by shared genetic influences. En ligne : https://doi.org/10.1111/jcpp.13808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1232-1241[article] Pubertal timing and adolescent outcomes: investigating explanations for associations with a genetically informed design [Texte imprimé et/ou numérique] / Emily R. PADRUTT, Auteur ; Jeremy HARPER, Auteur ; Jonathan D. SCHAEFER, Auteur ; Kayla M. NELSON, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Sylia WILSON, Auteur . - p.1232-1241.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1232-1241
Mots-clés : Pubertal timing substance use risky behavior peer problems psychopathology Index. décimale : PER Périodiques Résumé : Background Psychopathology and risky behaviors increase during adolescence, and understanding which adolescents are most at risk informs prevention and intervention efforts. Pubertal timing relative to same-sex, same-age peers is a known correlate of adolescent outcomes among both boys and girls. However, it remains unclear whether this relation is better explained by a plausible causal process or unobserved familial liability. Methods We extended previous research by examining associations between pubertal timing in early adolescence (age 14) and outcomes in later adolescence (age 17) in a community sample of 2,510 twins (49% boys, 51% girls). Results Earlier pubertal timing was associated with more substance use, risk behavior, internalizing and externalizing problems, and peer problems in later adolescence; these effects were small, consistent with previous literature. Follow-up co-twin control analyses indicated that within-twin-pair differences in pubertal timing were not associated with within-twin-pair differences in most adolescent outcomes after accounting for shared familial liability, suggesting that earlier pubertal timing and adolescent outcomes both reflect familial risk factors. Biometric models indicated that associations between earlier pubertal timing and negative adolescent outcomes were largely attributable to shared genetic liability. Conclusions Although earlier pubertal timing was associated with negative adolescent outcomes, our results suggests that these associations did not appear to be caused by earlier pubertal timing but were likely caused by shared genetic influences. En ligne : https://doi.org/10.1111/jcpp.13808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: A longitudinal twin study / Marina A. BORNOVALOVA in Development and Psychopathology, 21-4 (November 2009)
[article]
Titre : Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: A longitudinal twin study Type de document : Texte imprimé et/ou numérique Auteurs : Marina A. BORNOVALOVA, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur ; Brian M. HICKS, Auteur Année de publication : 2009 Article en page(s) : p.1335-1353 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although personality disorders are best understood in the context of lifetime development, there is a paucity of work examining their longitudinal trajectory. An understanding of the expected course and the genetic and environmental contributions to these disorders is necessary for a detailed understanding of risk processes that lead to their manifestation. The current study examined the longitudinal course and heritability of borderline personality disorder (BPD) over a period of 10 years starting in adolescence (age 14) and ending in adulthood (age 24). In doing so, we built on existing research by using a large community sample of adolescent female twins, a sensitive dimensional measure of BPD traits, an extended follow-up period, and a longitudinal twin design that allowed us to investigate the heritability of BPD traits at four discrete ages spanning midadolescence to early adulthood. Results indicated that mean-level BPD traits significantly decline from adolescence to adulthood, but rank order stability remained high. BPD traits were moderately heritable at all ages, with a slight trend for increased heritability from age 14 to age 24. A genetically informed latent growth curve model indicated that both the stability and change of BPD traits are highly influenced by genetic factors and modestly by nonshared environmental factors. Our results indicate that as is the case for other personality dimensions, trait BPD declines as individuals mature from adolescence to adulthood, and that this process is influenced in part by the same genetic factors that influence BPD trait stability. En ligne : http://dx.doi.org/10.1017/s0954579409990186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=847
in Development and Psychopathology > 21-4 (November 2009) . - p.1335-1353[article] Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: A longitudinal twin study [Texte imprimé et/ou numérique] / Marina A. BORNOVALOVA, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur ; Brian M. HICKS, Auteur . - 2009 . - p.1335-1353.
Langues : Anglais (eng)
in Development and Psychopathology > 21-4 (November 2009) . - p.1335-1353
Index. décimale : PER Périodiques Résumé : Although personality disorders are best understood in the context of lifetime development, there is a paucity of work examining their longitudinal trajectory. An understanding of the expected course and the genetic and environmental contributions to these disorders is necessary for a detailed understanding of risk processes that lead to their manifestation. The current study examined the longitudinal course and heritability of borderline personality disorder (BPD) over a period of 10 years starting in adolescence (age 14) and ending in adulthood (age 24). In doing so, we built on existing research by using a large community sample of adolescent female twins, a sensitive dimensional measure of BPD traits, an extended follow-up period, and a longitudinal twin design that allowed us to investigate the heritability of BPD traits at four discrete ages spanning midadolescence to early adulthood. Results indicated that mean-level BPD traits significantly decline from adolescence to adulthood, but rank order stability remained high. BPD traits were moderately heritable at all ages, with a slight trend for increased heritability from age 14 to age 24. A genetically informed latent growth curve model indicated that both the stability and change of BPD traits are highly influenced by genetic factors and modestly by nonshared environmental factors. Our results indicate that as is the case for other personality dimensions, trait BPD declines as individuals mature from adolescence to adulthood, and that this process is influenced in part by the same genetic factors that influence BPD trait stability. En ligne : http://dx.doi.org/10.1017/s0954579409990186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=847 The developmental progression of age 14 behavioral disinhibition, early age of sexual initiation, and subsequent sexual risk-taking behavior / Diana R. SAMEK in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)
[article]
Titre : The developmental progression of age 14 behavioral disinhibition, early age of sexual initiation, and subsequent sexual risk-taking behavior Type de document : Texte imprimé et/ou numérique Auteurs : Diana R. SAMEK, Auteur ; William G. IACONO, Auteur ; Margaret A. KEYES, Auteur ; Marina EPSTEIN, Auteur ; Marina A. BORNOVALOVA, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.784-792 Langues : Anglais (eng) Mots-clés : Behavior genetics behavioral disinhibition externalizing disorder gender differences sexual behavior Index. décimale : PER Périodiques Résumé : Background Research has demonstrated a consistent relationship between early sexual experience and subsequent sexual risk-taking behaviors. We hypothesized that this relationship is due to a general predisposition toward behavioral disinhibition (BD), and that relationships among BD, early sex, and subsequent risky sexual behavior may be influenced by common genetic influences for males and common environmental influences for females. Methods A prospective sample of 1,512 same-sex adolescent twins (50.2% female) was used. Adolescent BD was measured by clinical symptom counts of conduct disorder, oppositional defiant disorder, and self-reported delinquent behavior (age 14). Age of sexual initiation was defined as first age of consensual oral or penetrative sex (mean age ~17). Adult risky sexual behavior was defined by sexual behaviors under the influence of drugs and alcohol and number of casual sexual partners in the past year (age 24). Results Multivariate analyses showed evidence for substantial common genetic variance among age 14 BD, age at sexual initiation, and adult risky sexual behavior for males, but not females. There was no significant difference in the degree of common environmental influence on these variables for females compared to males. Notably, age of sexual initiation was not significantly correlated with age 24 risky sexual behavior for females. Conclusion The relationship between early sex and later risky sex can be better understood through a general liability toward BD, which is influenced primarily by genetic factors for males. The association between age 14 BD and age of sexual initiation was influenced through a combination of genetic and environmental factors for females; however, age of sexual initiation does not appear to be a salient predictor of adult women's sexual risk-taking behavior. Findings suggest that prevention programs aimed at reducing sexual risk behavior might target youth exhibiting BD by age 14, particularly males. More research is needed on what predicts adult sexual risk-taking behavior for females. En ligne : http://dx.doi.org/10.1111/jcpp.12176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.784-792[article] The developmental progression of age 14 behavioral disinhibition, early age of sexual initiation, and subsequent sexual risk-taking behavior [Texte imprimé et/ou numérique] / Diana R. SAMEK, Auteur ; William G. IACONO, Auteur ; Margaret A. KEYES, Auteur ; Marina EPSTEIN, Auteur ; Marina A. BORNOVALOVA, Auteur ; Matt MCGUE, Auteur . - p.784-792.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.784-792
Mots-clés : Behavior genetics behavioral disinhibition externalizing disorder gender differences sexual behavior Index. décimale : PER Périodiques Résumé : Background Research has demonstrated a consistent relationship between early sexual experience and subsequent sexual risk-taking behaviors. We hypothesized that this relationship is due to a general predisposition toward behavioral disinhibition (BD), and that relationships among BD, early sex, and subsequent risky sexual behavior may be influenced by common genetic influences for males and common environmental influences for females. Methods A prospective sample of 1,512 same-sex adolescent twins (50.2% female) was used. Adolescent BD was measured by clinical symptom counts of conduct disorder, oppositional defiant disorder, and self-reported delinquent behavior (age 14). Age of sexual initiation was defined as first age of consensual oral or penetrative sex (mean age ~17). Adult risky sexual behavior was defined by sexual behaviors under the influence of drugs and alcohol and number of casual sexual partners in the past year (age 24). Results Multivariate analyses showed evidence for substantial common genetic variance among age 14 BD, age at sexual initiation, and adult risky sexual behavior for males, but not females. There was no significant difference in the degree of common environmental influence on these variables for females compared to males. Notably, age of sexual initiation was not significantly correlated with age 24 risky sexual behavior for females. Conclusion The relationship between early sex and later risky sex can be better understood through a general liability toward BD, which is influenced primarily by genetic factors for males. The association between age 14 BD and age of sexual initiation was influenced through a combination of genetic and environmental factors for females; however, age of sexual initiation does not appear to be a salient predictor of adult women's sexual risk-taking behavior. Findings suggest that prevention programs aimed at reducing sexual risk behavior might target youth exhibiting BD by age 14, particularly males. More research is needed on what predicts adult sexual risk-taking behavior for females. En ligne : http://dx.doi.org/10.1111/jcpp.12176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 The Impact of Attention-Deficit/Hyperactivity Disorder on Preadolescent Adjustment May Be Greater for Girls Than for Boys / Irene J. EIKINS in Journal of Clinical Child & Adolescent Psychology, 40-4 (July-August 2011)
[article]
Titre : The Impact of Attention-Deficit/Hyperactivity Disorder on Preadolescent Adjustment May Be Greater for Girls Than for Boys Type de document : Texte imprimé et/ou numérique Auteurs : Irene J. EIKINS, Auteur ; Steve MALONE, Auteur ; Margaret KEYES, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur Année de publication : 2011 Article en page(s) : p.532-545 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Whether gender differences exist in the impairment associated with attention-deficit/hyperactivity disorder (ADHD) is still largely unknown, because most samples have few affected girls or include only one sex. The current study evaluated whether ADHD affects adjustment differently for girls than boys in a population-based cohort of 11-year-olds (520 girls, 478 boys). Those with a DSM-IV diagnosis of ADHD (predominantly inattentive, hyperactive-impulsive, or combined) were compared to those without ADHD on teacher, parent, and child reports of academics, peer relationships, self-concept, clinical symptoms, and treatment. Although boys and girls with ADHD experienced difficulties in all areas, girls with ADHD, especially the inattentive subtype, were more negatively affected in academics and peer relationships. Inattentive girls were less popular and more likely to be bullied than girls without ADHD, whereas inattentive boys were not. The social isolation experienced by many girls with ADHD deserves greater attention. En ligne : http://dx.doi.org/10.1080/15374416.2011.581621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132
in Journal of Clinical Child & Adolescent Psychology > 40-4 (July-August 2011) . - p.532-545[article] The Impact of Attention-Deficit/Hyperactivity Disorder on Preadolescent Adjustment May Be Greater for Girls Than for Boys [Texte imprimé et/ou numérique] / Irene J. EIKINS, Auteur ; Steve MALONE, Auteur ; Margaret KEYES, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur . - 2011 . - p.532-545.
Langues : Anglais (eng)
in Journal of Clinical Child & Adolescent Psychology > 40-4 (July-August 2011) . - p.532-545
Index. décimale : PER Périodiques Résumé : Whether gender differences exist in the impairment associated with attention-deficit/hyperactivity disorder (ADHD) is still largely unknown, because most samples have few affected girls or include only one sex. The current study evaluated whether ADHD affects adjustment differently for girls than boys in a population-based cohort of 11-year-olds (520 girls, 478 boys). Those with a DSM-IV diagnosis of ADHD (predominantly inattentive, hyperactive-impulsive, or combined) were compared to those without ADHD on teacher, parent, and child reports of academics, peer relationships, self-concept, clinical symptoms, and treatment. Although boys and girls with ADHD experienced difficulties in all areas, girls with ADHD, especially the inattentive subtype, were more negatively affected in academics and peer relationships. Inattentive girls were less popular and more likely to be bullied than girls without ADHD, whereas inattentive boys were not. The social isolation experienced by many girls with ADHD deserves greater attention. En ligne : http://dx.doi.org/10.1080/15374416.2011.581621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 The role of parental marital discord in the etiology of externalizing problems during childhood and adolescence / Amber M. JARNECKE in Development and Psychopathology, 29-4 (October 2017)
PermalinkTime-varying effects of families and peers on adolescent marijuana use: Person–environment interactions across development / Marina EPSTEIN in Development and Psychopathology, 29-3 (August 2017)
PermalinkTrait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation / Merav H. SILVERMAN in Development and Psychopathology, 31-3 (August 2019)
PermalinkA Twin Study of State and Trait Anxiety in Childhood and Adolescence / Lisa N. LEGRAND in Journal of Child Psychology and Psychiatry, 40-6 (September 1999)
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