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Auteur Margaret A. KEYES |
Documents disponibles écrits par cet auteur (2)
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Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction / Diana R. SAMEK in Development and Psychopathology, 29-1 (February 2017)
[article]
Titre : Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction Type de document : Texte imprimé et/ou numérique Auteurs : Diana R. SAMEK, Auteur ; Brian M. HICKS, Auteur ; Margaret A. KEYES, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.155-172 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : AbstractGene × Environment interaction contributes to externalizing disorders in childhood and adolescence, but little is known about whether such effects are long lasting or present in adulthood. We examined gene–environment interplay in the concurrent and prospective associations between antisocial peer affiliation and externalizing disorders (antisocial behavior and substance use disorders) at ages 17, 20, 24, and 29. The sample included 1,382 same-sex twin pairs participating in the Minnesota Twin Family Study. We detected a Gene × Environment interaction at age 17, such that additive genetic influences on antisocial behavior and substance use disorders were greater in the context of greater antisocial peer affiliation. This Gene × Environment interaction was not present for antisocial behavior symptoms after age 17, but it was for substance use disorder symptoms through age 29 (though effect sizes were largest at age 17). The results suggest adolescence is a critical period for the development of externalizing disorders wherein exposure to greater environmental adversity is associated with a greater expression of genetic risk. This form of Gene × Environment interaction may persist through young adulthood for substance use disorders, but it appears to be limited to adolescence for antisocial behavior. En ligne : http://dx.doi.org/10.1017/s0954579416000109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Development and Psychopathology > 29-1 (February 2017) . - p.155-172[article] Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction [Texte imprimé et/ou numérique] / Diana R. SAMEK, Auteur ; Brian M. HICKS, Auteur ; Margaret A. KEYES, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur . - p.155-172.
Langues : Anglais (eng)
in Development and Psychopathology > 29-1 (February 2017) . - p.155-172
Index. décimale : PER Périodiques Résumé : AbstractGene × Environment interaction contributes to externalizing disorders in childhood and adolescence, but little is known about whether such effects are long lasting or present in adulthood. We examined gene–environment interplay in the concurrent and prospective associations between antisocial peer affiliation and externalizing disorders (antisocial behavior and substance use disorders) at ages 17, 20, 24, and 29. The sample included 1,382 same-sex twin pairs participating in the Minnesota Twin Family Study. We detected a Gene × Environment interaction at age 17, such that additive genetic influences on antisocial behavior and substance use disorders were greater in the context of greater antisocial peer affiliation. This Gene × Environment interaction was not present for antisocial behavior symptoms after age 17, but it was for substance use disorder symptoms through age 29 (though effect sizes were largest at age 17). The results suggest adolescence is a critical period for the development of externalizing disorders wherein exposure to greater environmental adversity is associated with a greater expression of genetic risk. This form of Gene × Environment interaction may persist through young adulthood for substance use disorders, but it appears to be limited to adolescence for antisocial behavior. En ligne : http://dx.doi.org/10.1017/s0954579416000109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 The developmental progression of age 14 behavioral disinhibition, early age of sexual initiation, and subsequent sexual risk-taking behavior / Diana R. SAMEK in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)
[article]
Titre : The developmental progression of age 14 behavioral disinhibition, early age of sexual initiation, and subsequent sexual risk-taking behavior Type de document : Texte imprimé et/ou numérique Auteurs : Diana R. SAMEK, Auteur ; William G. IACONO, Auteur ; Margaret A. KEYES, Auteur ; Marina EPSTEIN, Auteur ; Marina A. BORNOVALOVA, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.784-792 Langues : Anglais (eng) Mots-clés : Behavior genetics behavioral disinhibition externalizing disorder gender differences sexual behavior Index. décimale : PER Périodiques Résumé : Background Research has demonstrated a consistent relationship between early sexual experience and subsequent sexual risk-taking behaviors. We hypothesized that this relationship is due to a general predisposition toward behavioral disinhibition (BD), and that relationships among BD, early sex, and subsequent risky sexual behavior may be influenced by common genetic influences for males and common environmental influences for females. Methods A prospective sample of 1,512 same-sex adolescent twins (50.2% female) was used. Adolescent BD was measured by clinical symptom counts of conduct disorder, oppositional defiant disorder, and self-reported delinquent behavior (age 14). Age of sexual initiation was defined as first age of consensual oral or penetrative sex (mean age ~17). Adult risky sexual behavior was defined by sexual behaviors under the influence of drugs and alcohol and number of casual sexual partners in the past year (age 24). Results Multivariate analyses showed evidence for substantial common genetic variance among age 14 BD, age at sexual initiation, and adult risky sexual behavior for males, but not females. There was no significant difference in the degree of common environmental influence on these variables for females compared to males. Notably, age of sexual initiation was not significantly correlated with age 24 risky sexual behavior for females. Conclusion The relationship between early sex and later risky sex can be better understood through a general liability toward BD, which is influenced primarily by genetic factors for males. The association between age 14 BD and age of sexual initiation was influenced through a combination of genetic and environmental factors for females; however, age of sexual initiation does not appear to be a salient predictor of adult women's sexual risk-taking behavior. Findings suggest that prevention programs aimed at reducing sexual risk behavior might target youth exhibiting BD by age 14, particularly males. More research is needed on what predicts adult sexual risk-taking behavior for females. En ligne : http://dx.doi.org/10.1111/jcpp.12176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.784-792[article] The developmental progression of age 14 behavioral disinhibition, early age of sexual initiation, and subsequent sexual risk-taking behavior [Texte imprimé et/ou numérique] / Diana R. SAMEK, Auteur ; William G. IACONO, Auteur ; Margaret A. KEYES, Auteur ; Marina EPSTEIN, Auteur ; Marina A. BORNOVALOVA, Auteur ; Matt MCGUE, Auteur . - p.784-792.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.784-792
Mots-clés : Behavior genetics behavioral disinhibition externalizing disorder gender differences sexual behavior Index. décimale : PER Périodiques Résumé : Background Research has demonstrated a consistent relationship between early sexual experience and subsequent sexual risk-taking behaviors. We hypothesized that this relationship is due to a general predisposition toward behavioral disinhibition (BD), and that relationships among BD, early sex, and subsequent risky sexual behavior may be influenced by common genetic influences for males and common environmental influences for females. Methods A prospective sample of 1,512 same-sex adolescent twins (50.2% female) was used. Adolescent BD was measured by clinical symptom counts of conduct disorder, oppositional defiant disorder, and self-reported delinquent behavior (age 14). Age of sexual initiation was defined as first age of consensual oral or penetrative sex (mean age ~17). Adult risky sexual behavior was defined by sexual behaviors under the influence of drugs and alcohol and number of casual sexual partners in the past year (age 24). Results Multivariate analyses showed evidence for substantial common genetic variance among age 14 BD, age at sexual initiation, and adult risky sexual behavior for males, but not females. There was no significant difference in the degree of common environmental influence on these variables for females compared to males. Notably, age of sexual initiation was not significantly correlated with age 24 risky sexual behavior for females. Conclusion The relationship between early sex and later risky sex can be better understood through a general liability toward BD, which is influenced primarily by genetic factors for males. The association between age 14 BD and age of sexual initiation was influenced through a combination of genetic and environmental factors for females; however, age of sexual initiation does not appear to be a salient predictor of adult women's sexual risk-taking behavior. Findings suggest that prevention programs aimed at reducing sexual risk behavior might target youth exhibiting BD by age 14, particularly males. More research is needed on what predicts adult sexual risk-taking behavior for females. En ligne : http://dx.doi.org/10.1111/jcpp.12176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235