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Détail de l'auteur
Auteur Claire AMIET |
Documents disponibles écrits par cet auteur (2)
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Autisme et épilepsie / Claire AMIET in Sésame, 173 (1er trimestre 2010)
[article]
Titre : Autisme et épilepsie Type de document : Texte imprimé et/ou numérique Auteurs : Claire AMIET, Auteur Année de publication : 2010 Article en page(s) : p.2-3 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=997
in Sésame > 173 (1er trimestre 2010) . - p.2-3[article] Autisme et épilepsie [Texte imprimé et/ou numérique] / Claire AMIET, Auteur . - 2010 . - p.2-3.
Langues : Français (fre)
in Sésame > 173 (1er trimestre 2010) . - p.2-3
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=997 Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk? / Claire AMIET in Molecular Autism, (December 2013)
[article]
Titre : Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk? Type de document : Texte imprimé et/ou numérique Auteurs : Claire AMIET, Auteur ; Isabelle GOURFINKEL-AN, Auteur ; Claudine LAURENT, Auteur ; Nicolas BODEAU, Auteur ; Berengere GENIN, Auteur ; Eric LEGUERN, Auteur ; Sylvie TORDJMAN, Auteur ; David COHEN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and epilepsy frequently occur together. Prevalence rates are variable, and have been attributed to age, gender, comorbidity, subtype of pervasive developmental disorder (PDD) and risk factors. Recent studies have suggested disparate clinical and genetic settings depending on simplex or multiplex autism. The aim of this study was to assess: 1) the prevalence of epilepsy in multiplex autism and its association with genetic and non-genetic risk factors of major effect, intellectual disability and gender; and 2) whether autism and epilepsy cosegregate within multiplex autism families. We extracted from the Autism Genetic Resource Exchange (AGRE) database (n=3,818 children from 1,264 families) all families with relevant medical data (n=664 children from 290 families). The sample included 478 children with ASD and 186 siblings without ASD. We analyzed the following variables: seizures, genetic and non-genetic risk factors, gender, and cognitive functioning as assessed by Raven's Colored Progressive Matrices (RCPM) and Vineland Adaptive Behavior Scales (VABS). The prevalence of epilepsy was 12.8% in cases with ASD and 2.2% in siblings without ASD (P 10-5). With each RCPM or VABS measure, the risk of epilepsy in multiplex autism was significantly associated with intellectual disability, but not with gender. Identified risk factors (genetic or non-genetic) of autism tended to be significantly associated with epilepsy (P=0.052). When children with prematurity, pre- or perinatal insult, or cerebral palsy were excluded, a genetic risk factor was reported for 6/59 (10.2%) of children with epilepsy and 12/395 (3.0%) of children without epilepsy (P=0.002). Finally, using a permutation test, there was significant evidence that the epilepsy phenotype co-segregated within families (P 10-4). Epilepsy in multiplex autism may define a different subgroup in terms of clinical characteristics and genetic risk. En ligne : http://dx.doi.org/10.1186/2040-2392-4-47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (December 2013)[article] Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk? [Texte imprimé et/ou numérique] / Claire AMIET, Auteur ; Isabelle GOURFINKEL-AN, Auteur ; Claudine LAURENT, Auteur ; Nicolas BODEAU, Auteur ; Berengere GENIN, Auteur ; Eric LEGUERN, Auteur ; Sylvie TORDJMAN, Auteur ; David COHEN, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (December 2013)
Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and epilepsy frequently occur together. Prevalence rates are variable, and have been attributed to age, gender, comorbidity, subtype of pervasive developmental disorder (PDD) and risk factors. Recent studies have suggested disparate clinical and genetic settings depending on simplex or multiplex autism. The aim of this study was to assess: 1) the prevalence of epilepsy in multiplex autism and its association with genetic and non-genetic risk factors of major effect, intellectual disability and gender; and 2) whether autism and epilepsy cosegregate within multiplex autism families. We extracted from the Autism Genetic Resource Exchange (AGRE) database (n=3,818 children from 1,264 families) all families with relevant medical data (n=664 children from 290 families). The sample included 478 children with ASD and 186 siblings without ASD. We analyzed the following variables: seizures, genetic and non-genetic risk factors, gender, and cognitive functioning as assessed by Raven's Colored Progressive Matrices (RCPM) and Vineland Adaptive Behavior Scales (VABS). The prevalence of epilepsy was 12.8% in cases with ASD and 2.2% in siblings without ASD (P 10-5). With each RCPM or VABS measure, the risk of epilepsy in multiplex autism was significantly associated with intellectual disability, but not with gender. Identified risk factors (genetic or non-genetic) of autism tended to be significantly associated with epilepsy (P=0.052). When children with prematurity, pre- or perinatal insult, or cerebral palsy were excluded, a genetic risk factor was reported for 6/59 (10.2%) of children with epilepsy and 12/395 (3.0%) of children without epilepsy (P=0.002). Finally, using a permutation test, there was significant evidence that the epilepsy phenotype co-segregated within families (P 10-4). Epilepsy in multiplex autism may define a different subgroup in terms of clinical characteristics and genetic risk. En ligne : http://dx.doi.org/10.1186/2040-2392-4-47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227