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Auteur Marcel A. DE REUS |
Documents disponibles écrits par cet auteur (1)
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Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder / Dienke J. BOS in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)
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Titre : Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dienke J. BOS, Auteur ; Bob ORANJE, Auteur ; Michelle ACHTERBERG, Auteur ; Chantal VLASKAMP, Auteur ; Sara AMBROSINO, Auteur ; Marcel A. DE REUS, Auteur ; Martijn P. VAN DEN HEUVEL, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Sarah DURSTON, Auteur Article en page(s) : p.810-818 Langues : Anglais (eng) Mots-clés : Attention deficit/hyperactivity disorder functional connectivity structural connectivity Default Mode Network developmental delay Index. décimale : PER Périodiques Résumé : Background Attention deficit/hyperactivity disorder (ADHD) has frequently been associated with changes in resting-state functional connectivity, and decreased white matter (WM) integrity. In the current study, we investigated functional connectivity within Default Mode and frontal control resting-state networks (RSNs) in children with and without ADHD. We hypothesized the RSNs of interest would show a pattern of impaired functional integration and segregation and corresponding changes in WM structure. Methods Resting-state fMRI and diffusion-weighted imaging data were acquired from 35 participants with ADHD and 36 matched typically developing peers, aged 6 through 18 years. Functional connectivity was assessed using independent component analysis. Network topology and WM connectivity were further investigated using graph theoretical measures and tract-based spatial statistics (TBSS). Results Resting-state fMRI analyses showed increased functional connectivity in right inferior frontal gyrus (IFG), and bilateral medial prefrontal cortex (mPFC) within the Default Mode and frontal control networks. Furthermore, a more diffuse spatial pattern of functional connectivity was found in children with ADHD. We found no group differences in structural connectivity as assessed with TBSS or graph theoretical measures. Conclusions Resting-state networks show a more diffuse pattern of connectivity in children with ADHD. The increases in functional connectivity in right IFG and bilateral mPFC in children with ADHD may reflect reduced or delayed functional segregation of prefrontal brain regions. As these functional changes were not accompanied by changes in WM, they may precede the development of the frequently reported changes in WM structure. En ligne : http://dx.doi.org/10.1111/jcpp.12712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316
in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.810-818[article] Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Dienke J. BOS, Auteur ; Bob ORANJE, Auteur ; Michelle ACHTERBERG, Auteur ; Chantal VLASKAMP, Auteur ; Sara AMBROSINO, Auteur ; Marcel A. DE REUS, Auteur ; Martijn P. VAN DEN HEUVEL, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Sarah DURSTON, Auteur . - p.810-818.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.810-818
Mots-clés : Attention deficit/hyperactivity disorder functional connectivity structural connectivity Default Mode Network developmental delay Index. décimale : PER Périodiques Résumé : Background Attention deficit/hyperactivity disorder (ADHD) has frequently been associated with changes in resting-state functional connectivity, and decreased white matter (WM) integrity. In the current study, we investigated functional connectivity within Default Mode and frontal control resting-state networks (RSNs) in children with and without ADHD. We hypothesized the RSNs of interest would show a pattern of impaired functional integration and segregation and corresponding changes in WM structure. Methods Resting-state fMRI and diffusion-weighted imaging data were acquired from 35 participants with ADHD and 36 matched typically developing peers, aged 6 through 18 years. Functional connectivity was assessed using independent component analysis. Network topology and WM connectivity were further investigated using graph theoretical measures and tract-based spatial statistics (TBSS). Results Resting-state fMRI analyses showed increased functional connectivity in right inferior frontal gyrus (IFG), and bilateral medial prefrontal cortex (mPFC) within the Default Mode and frontal control networks. Furthermore, a more diffuse spatial pattern of functional connectivity was found in children with ADHD. We found no group differences in structural connectivity as assessed with TBSS or graph theoretical measures. Conclusions Resting-state networks show a more diffuse pattern of connectivity in children with ADHD. The increases in functional connectivity in right IFG and bilateral mPFC in children with ADHD may reflect reduced or delayed functional segregation of prefrontal brain regions. As these functional changes were not accompanied by changes in WM, they may precede the development of the frequently reported changes in WM structure. En ligne : http://dx.doi.org/10.1111/jcpp.12712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316