Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur E. T. KAVALALI |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Role of MeCP2, DNA methylation, and HDACs in regulating synapse function / E. T. KAVALALI in Journal of Neurodevelopmental Disorders, 3-3 (September 2011)
[article]
Titre : Role of MeCP2, DNA methylation, and HDACs in regulating synapse function Type de document : Texte imprimé et/ou numérique Auteurs : E. T. KAVALALI, Auteur ; E. D. NELSON, Auteur ; L. M. MONTEGGIA, Auteur Article en page(s) : p.250-6 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Over the past several years there has been intense effort to delineate the role of epigenetic factors, including methyl-CpG-binding protein 2, histone deacetylases, and DNA methyltransferases, in synaptic function. Studies from our group as well as others have shown that these key epigenetic mechanisms are critical regulators of synapse formation, maturation, as well as function. Although most studies have identified selective deficits in excitatory neurotransmission, the latest work has also uncovered deficits in inhibitory neurotransmission as well. Despite the rapid pace of advances, the exact synaptic mechanisms and gene targets that mediate these effects on neurotransmission remain unclear. Nevertheless, these findings not only open new avenues for understanding neuronal circuit abnormalities associated with neurodevelopmental disorders but also elucidate potential targets for addressing the pathophysiology of several intractable neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-011-9078-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343
in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.250-6[article] Role of MeCP2, DNA methylation, and HDACs in regulating synapse function [Texte imprimé et/ou numérique] / E. T. KAVALALI, Auteur ; E. D. NELSON, Auteur ; L. M. MONTEGGIA, Auteur . - p.250-6.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.250-6
Index. décimale : PER Périodiques Résumé : Over the past several years there has been intense effort to delineate the role of epigenetic factors, including methyl-CpG-binding protein 2, histone deacetylases, and DNA methyltransferases, in synaptic function. Studies from our group as well as others have shown that these key epigenetic mechanisms are critical regulators of synapse formation, maturation, as well as function. Although most studies have identified selective deficits in excitatory neurotransmission, the latest work has also uncovered deficits in inhibitory neurotransmission as well. Despite the rapid pace of advances, the exact synaptic mechanisms and gene targets that mediate these effects on neurotransmission remain unclear. Nevertheless, these findings not only open new avenues for understanding neuronal circuit abnormalities associated with neurodevelopmental disorders but also elucidate potential targets for addressing the pathophysiology of several intractable neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-011-9078-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343