Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur B. P. HALLAHAN |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Fragile X syndrome: a pilot proton magnetic resonance spectroscopy study in premutation carriers / B. P. HALLAHAN in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)
[article]
Titre : Fragile X syndrome: a pilot proton magnetic resonance spectroscopy study in premutation carriers Type de document : Texte imprimé et/ou numérique Auteurs : B. P. HALLAHAN, Auteur ; Eileen DALY, Auteur ; A. SIMMONS, Auteur ; C. J. MOORE, Auteur ; K. C. MURPHY, Auteur ; D. D. MURPHY, Auteur Article en page(s) : p.23 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : PURPOSE: There is increasing evidence that neurodevelopmental differences in people with Fragile X syndrome (FraX) may be explained by differences in glutamatergic metabolism. Premutation carriers of FraX were originally considered to be unaffected although several recent reports demonstrate neuroanatomical, cognitive, and emotional differences from controls. However there are few studies on brain metabolism in premutation carriers of FraX. METHODS: We used proton magnetic resonance spectroscopy to compare neuronal integrity of a number of brain metabolites including N-Acetyl Aspartate, Creatine + Phosphocreatinine, Choline, myoInositol, and Glutamate containing substances (Glx) in 17 male premutation carriers of FraX and 16 male healthy control individuals. RESULTS: There was no significant between-group difference in the concentration of any measured brain metabolites. However there was a differential increase in N-acetyl aspartate with aging in premutation FraX individuals compared to controls. CONCLUSIONS: This is the first 1 H-MRS study to examine premutation FraX individuals. Although we demonstrated no difference in the concentration of any of the metabolites examined between the groups, this may be due to the large age ranges included in the two samples. The differential increase in NAA levels with aging may reflect an abnormal synaptic pruning process. En ligne : http://dx.doi.org/10.1186/1866-1955-4-23 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344
in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.23[article] Fragile X syndrome: a pilot proton magnetic resonance spectroscopy study in premutation carriers [Texte imprimé et/ou numérique] / B. P. HALLAHAN, Auteur ; Eileen DALY, Auteur ; A. SIMMONS, Auteur ; C. J. MOORE, Auteur ; K. C. MURPHY, Auteur ; D. D. MURPHY, Auteur . - p.23.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.23
Index. décimale : PER Périodiques Résumé : PURPOSE: There is increasing evidence that neurodevelopmental differences in people with Fragile X syndrome (FraX) may be explained by differences in glutamatergic metabolism. Premutation carriers of FraX were originally considered to be unaffected although several recent reports demonstrate neuroanatomical, cognitive, and emotional differences from controls. However there are few studies on brain metabolism in premutation carriers of FraX. METHODS: We used proton magnetic resonance spectroscopy to compare neuronal integrity of a number of brain metabolites including N-Acetyl Aspartate, Creatine + Phosphocreatinine, Choline, myoInositol, and Glutamate containing substances (Glx) in 17 male premutation carriers of FraX and 16 male healthy control individuals. RESULTS: There was no significant between-group difference in the concentration of any measured brain metabolites. However there was a differential increase in N-acetyl aspartate with aging in premutation FraX individuals compared to controls. CONCLUSIONS: This is the first 1 H-MRS study to examine premutation FraX individuals. Although we demonstrated no difference in the concentration of any of the metabolites examined between the groups, this may be due to the large age ranges included in the two samples. The differential increase in NAA levels with aging may reflect an abnormal synaptic pruning process. En ligne : http://dx.doi.org/10.1186/1866-1955-4-23 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344