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Détail de l'auteur
Auteur Q. A. CLASS |
Documents disponibles écrits par cet auteur (2)
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Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study / Y. GINSBERG in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)
[article]
Titre : Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study Type de document : Texte imprimé et/ou numérique Auteurs : Y. GINSBERG, Auteur ; B. M. D'ONOFRIO, Auteur ; M. E. RICKERT, Auteur ; Q. A. CLASS, Auteur ; M. A. ROSENQVIST, Auteur ; Catarina ALMQVIST, Auteur ; P. LICHTENSTEIN, Auteur ; H. LARSSON, Auteur Article en page(s) : p.160-168 Langues : Anglais (eng) Mots-clés : Maternal infection during pregnancy attention-deficit/hyperactivity disorder cousin comparisons familial confounding quasi-experimental sibling comparisons Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal infection during pregnancy (IDP) has been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. However, infection is associated with social adversity, poor living conditions and other background familial factors. As such, there is a need to rule out whether the observed association between maternal IDP and ADHD might be attributed to such confounding. METHODS: This nationwide population-based cohort study using a family-based, quasi-experimental design included 1,066,956 individuals born in Sweden between 1992 and 2002. Data on maternal IDP (bacterial or viral) requiring hospitalization and ADHD diagnosis in offspring were gathered from Swedish National Registers, with individuals followed up through the end of 2009. Ordinary and stratified Cox regression models were used for estimation of hazard ratios (HRs) and several measured covariates were considered. Cousin- and sibling-comparisons accounted for unmeasured genetic and environmental factors shared by cousins and siblings. RESULTS: In the entire population, maternal IDP was associated with ADHD in offspring (HR = 2.31, 95% CI = 2.04-2.61). This association was attenuated when accounting for measured covariates (HR = 1.86, 95% CI = 1.65-2.10). The association was further attenuated when adjusting for unmeasured factors shared between cousins (HR = 1.52, 95% CI = 1.12-2.07). Finally, the association was fully attenuated in sibling comparisons (HR = 1.03, 95% CI = 0.76-1.41). CONCLUSIONS: This study suggests that the association between maternal IDP and offspring ADHD is largely due to unmeasured familial confounding. Our results underscore the importance of adjusting for unobserved familial risk factors when exploring risk factors for ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381
in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.160-168[article] Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study [Texte imprimé et/ou numérique] / Y. GINSBERG, Auteur ; B. M. D'ONOFRIO, Auteur ; M. E. RICKERT, Auteur ; Q. A. CLASS, Auteur ; M. A. ROSENQVIST, Auteur ; Catarina ALMQVIST, Auteur ; P. LICHTENSTEIN, Auteur ; H. LARSSON, Auteur . - p.160-168.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.160-168
Mots-clés : Maternal infection during pregnancy attention-deficit/hyperactivity disorder cousin comparisons familial confounding quasi-experimental sibling comparisons Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal infection during pregnancy (IDP) has been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. However, infection is associated with social adversity, poor living conditions and other background familial factors. As such, there is a need to rule out whether the observed association between maternal IDP and ADHD might be attributed to such confounding. METHODS: This nationwide population-based cohort study using a family-based, quasi-experimental design included 1,066,956 individuals born in Sweden between 1992 and 2002. Data on maternal IDP (bacterial or viral) requiring hospitalization and ADHD diagnosis in offspring were gathered from Swedish National Registers, with individuals followed up through the end of 2009. Ordinary and stratified Cox regression models were used for estimation of hazard ratios (HRs) and several measured covariates were considered. Cousin- and sibling-comparisons accounted for unmeasured genetic and environmental factors shared by cousins and siblings. RESULTS: In the entire population, maternal IDP was associated with ADHD in offspring (HR = 2.31, 95% CI = 2.04-2.61). This association was attenuated when accounting for measured covariates (HR = 1.86, 95% CI = 1.65-2.10). The association was further attenuated when adjusting for unmeasured factors shared between cousins (HR = 1.52, 95% CI = 1.12-2.07). Finally, the association was fully attenuated in sibling comparisons (HR = 1.03, 95% CI = 0.76-1.41). CONCLUSIONS: This study suggests that the association between maternal IDP and offspring ADHD is largely due to unmeasured familial confounding. Our results underscore the importance of adjusting for unobserved familial risk factors when exploring risk factors for ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 Prospective test of the developmental propensity model of antisocial behavior: from childhood and adolescence into early adulthood / B. B. LAHEY in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)
[article]
Titre : Prospective test of the developmental propensity model of antisocial behavior: from childhood and adolescence into early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : B. B. LAHEY, Auteur ; Q. A. CLASS, Auteur ; D. H. ZALD, Auteur ; P. J. RATHOUZ, Auteur ; Brooks APPLEGATE, Auteur ; Irwin D. WALDMAN, Auteur Article en page(s) : p.676-683 Langues : Anglais (eng) Mots-clés : Developmental propensity model antisocial personality daring negative emotionality prosociality Index. décimale : PER Périodiques Résumé : BACKGROUND: The developmental propensity model of antisocial behavior posits that several dispositional characteristics of children transact with the environment to influence the likelihood of learning antisocial behavior across development. Specifically, greater dispositional negative emotionality, greater daring, and lower prosociality-operationally, the inverse of callousness- and lower cognitive abilities are each predicted to increase risk for developing antisocial behavior. METHODS: Prospective tests of key predictions derived from the model were conducted in a high-risk sample of 499 twins who were assessed on dispositions at 10-17 years of age and assessed for antisocial personality disorder (APD) symptoms at 22-31 years of age. Predictions were tested separately for parent and youth informants on the dispositions using multiple regressions that adjusted for oversampling, nonresponse, and clustering within twin pairs, controlling demographic factors and time since the first assessment. RESULTS: Consistent with predictions, greater numbers of APD symptoms in adulthood were independently predicted over a 10-15 year span by higher youth ratings on negative emotionality and daring and lower youth ratings on prosociality, and by parent ratings of greater negative emotionality and lower prosociality. A measure of working memory did not predict APD symptoms. CONCLUSIONS: These findings support future research on the role of these dispositions in the development of antisocial behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363
in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.676-683[article] Prospective test of the developmental propensity model of antisocial behavior: from childhood and adolescence into early adulthood [Texte imprimé et/ou numérique] / B. B. LAHEY, Auteur ; Q. A. CLASS, Auteur ; D. H. ZALD, Auteur ; P. J. RATHOUZ, Auteur ; Brooks APPLEGATE, Auteur ; Irwin D. WALDMAN, Auteur . - p.676-683.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.676-683
Mots-clés : Developmental propensity model antisocial personality daring negative emotionality prosociality Index. décimale : PER Périodiques Résumé : BACKGROUND: The developmental propensity model of antisocial behavior posits that several dispositional characteristics of children transact with the environment to influence the likelihood of learning antisocial behavior across development. Specifically, greater dispositional negative emotionality, greater daring, and lower prosociality-operationally, the inverse of callousness- and lower cognitive abilities are each predicted to increase risk for developing antisocial behavior. METHODS: Prospective tests of key predictions derived from the model were conducted in a high-risk sample of 499 twins who were assessed on dispositions at 10-17 years of age and assessed for antisocial personality disorder (APD) symptoms at 22-31 years of age. Predictions were tested separately for parent and youth informants on the dispositions using multiple regressions that adjusted for oversampling, nonresponse, and clustering within twin pairs, controlling demographic factors and time since the first assessment. RESULTS: Consistent with predictions, greater numbers of APD symptoms in adulthood were independently predicted over a 10-15 year span by higher youth ratings on negative emotionality and daring and lower youth ratings on prosociality, and by parent ratings of greater negative emotionality and lower prosociality. A measure of working memory did not predict APD symptoms. CONCLUSIONS: These findings support future research on the role of these dispositions in the development of antisocial behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363