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Détail de l'auteur
Auteur Beth REBOUSSIN |
Documents disponibles écrits par cet auteur (1)
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Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood / Jill A. RABINOWITZ in Development and Psychopathology, 32-2 (May 2020)
[article]
Titre : Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Jill A. RABINOWITZ, Auteur ; Rashelle J. MUSCI, Auteur ; Beth REBOUSSIN, Auteur ; Adam J. MILAM, Auteur ; Kelly S. BENKE, Auteur ; George R. UHL, Auteur ; Danielle Y. SISTO, Auteur ; Nicholas S. IALONGO, Auteur ; Brion S. MAHER, Auteur Article en page(s) : p.703-718 Langues : Anglais (eng) Mots-clés : alcohol use classes antisocial behavior polygenic risk score community disadvantage internalizing symptoms polygenic risk score parental monitoring Index. décimale : PER Périodiques Résumé : The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. En ligne : http://dx.doi.org/10.1017/s0954579419000701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Development and Psychopathology > 32-2 (May 2020) . - p.703-718[article] Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood [Texte imprimé et/ou numérique] / Jill A. RABINOWITZ, Auteur ; Rashelle J. MUSCI, Auteur ; Beth REBOUSSIN, Auteur ; Adam J. MILAM, Auteur ; Kelly S. BENKE, Auteur ; George R. UHL, Auteur ; Danielle Y. SISTO, Auteur ; Nicholas S. IALONGO, Auteur ; Brion S. MAHER, Auteur . - p.703-718.
Langues : Anglais (eng)
in Development and Psychopathology > 32-2 (May 2020) . - p.703-718
Mots-clés : alcohol use classes antisocial behavior polygenic risk score community disadvantage internalizing symptoms polygenic risk score parental monitoring Index. décimale : PER Périodiques Résumé : The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. En ligne : http://dx.doi.org/10.1017/s0954579419000701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426