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Auteur Lang HUANG |
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Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy / Cuixia FAN in Molecular Autism, 11 (2020)
[article]
Titre : Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy Type de document : Texte imprimé et/ou numérique Auteurs : Cuixia FAN, Auteur ; Yue GAO, Auteur ; Guanmei LIANG, Auteur ; Lang HUANG, Auteur ; Jing WANG, Auteur ; Xiaoxue YANG, Auteur ; Yiwu SHI, Auteur ; Ursula C DRÄGER, Auteur ; Mei ZHONG, Auteur ; Tian-Ming GAO, Auteur ; Xinping YANG, Auteur Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : Autism Epilepsy Gabra4 Interactome NMDARs Transcriptome Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neuronal developmental disorder with impaired social interaction and communication, often with abnormal intelligence and comorbidity with epilepsy. Disturbances in synaptic transmission, including the GABAergic, glutamatergic, and serotonergic systems, are known to be involved in the pathogenesis of this disorder, yet we do not know if there is a common molecular mechanism. As mutations in the GABAergic receptor subunit gene GABRA4 are reported in patients with ASD, we eliminated the Gabra4 gene in mice and found that the Gabra4 knockout mice showed autistic-like behavior, enhanced spatial memory, and attenuated susceptibility to pentylenetetrazol-induced seizures, a constellation of symptoms resembling human high-functioning autism. To search for potential molecular pathways involved in these phenotypes, we performed a hippocampal transcriptome profiling, constructed a hippocampal interactome network, and revealed an upregulation of the NMDAR system at the center of the converged pathways underlying high-functioning autism-like and anti-epilepsy phenotypes. En ligne : http://dx.doi.org/10.1186/s13229-020-0318-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 13 p.[article] Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy [Texte imprimé et/ou numérique] / Cuixia FAN, Auteur ; Yue GAO, Auteur ; Guanmei LIANG, Auteur ; Lang HUANG, Auteur ; Jing WANG, Auteur ; Xiaoxue YANG, Auteur ; Yiwu SHI, Auteur ; Ursula C DRÄGER, Auteur ; Mei ZHONG, Auteur ; Tian-Ming GAO, Auteur ; Xinping YANG, Auteur . - 13 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 13 p.
Mots-clés : Autism Epilepsy Gabra4 Interactome NMDARs Transcriptome Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neuronal developmental disorder with impaired social interaction and communication, often with abnormal intelligence and comorbidity with epilepsy. Disturbances in synaptic transmission, including the GABAergic, glutamatergic, and serotonergic systems, are known to be involved in the pathogenesis of this disorder, yet we do not know if there is a common molecular mechanism. As mutations in the GABAergic receptor subunit gene GABRA4 are reported in patients with ASD, we eliminated the Gabra4 gene in mice and found that the Gabra4 knockout mice showed autistic-like behavior, enhanced spatial memory, and attenuated susceptibility to pentylenetetrazol-induced seizures, a constellation of symptoms resembling human high-functioning autism. To search for potential molecular pathways involved in these phenotypes, we performed a hippocampal transcriptome profiling, constructed a hippocampal interactome network, and revealed an upregulation of the NMDAR system at the center of the converged pathways underlying high-functioning autism-like and anti-epilepsy phenotypes. En ligne : http://dx.doi.org/10.1186/s13229-020-0318-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427