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Détail de l'auteur
Auteur Rafael E. DELGADO |
Documents disponibles écrits par cet auteur (2)
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Newborn Auditory Brainstem Responses in Children with Developmental Disabilities / Elizabeth A. SIMPSON ; Guangyu ZENG ; Rafael E. DELGADO ; Oren MIRON in Journal of Autism and Developmental Disorders, 53-2 (February 2023)
[article]
Titre : Newborn Auditory Brainstem Responses in Children with Developmental Disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth A. SIMPSON, Auteur ; Guangyu ZENG, Auteur ; Rafael E. DELGADO, Auteur ; Oren MIRON, Auteur Article en page(s) : p.776-788 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We integrated data from a newborn hearing screening database and a preschool disability database to examine the relationship between newborn click evoked auditory brainstem responses (ABRs) and developmental disabilities. This sample included children with developmental delay (n = 2992), speech impairment (SI, n = 905), language impairment (n = 566), autism spectrum disorder (ASD, n = 370), and comparison children (n = 128,181). We compared the phase of the ABR waveform, a measure of sound processing latency, across groups. Children with SI and children with ASD had greater newborn ABR phase values than both the comparison group and the developmental delay group. Newborns later diagnosed with SI or ASD have slower neurological responses to auditory stimuli, suggesting sensory differences at birth. En ligne : https://doi.org/10.1007/s10803-021-05126-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495
in Journal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.776-788[article] Newborn Auditory Brainstem Responses in Children with Developmental Disabilities [Texte imprimé et/ou numérique] / Elizabeth A. SIMPSON, Auteur ; Guangyu ZENG, Auteur ; Rafael E. DELGADO, Auteur ; Oren MIRON, Auteur . - p.776-788.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.776-788
Index. décimale : PER Périodiques Résumé : We integrated data from a newborn hearing screening database and a preschool disability database to examine the relationship between newborn click evoked auditory brainstem responses (ABRs) and developmental disabilities. This sample included children with developmental delay (n = 2992), speech impairment (SI, n = 905), language impairment (n = 566), autism spectrum disorder (ASD, n = 370), and comparison children (n = 128,181). We compared the phase of the ABR waveform, a measure of sound processing latency, across groups. Children with SI and children with ASD had greater newborn ABR phase values than both the comparison group and the developmental delay group. Newborns later diagnosed with SI or ASD have slower neurological responses to auditory stimuli, suggesting sensory differences at birth. En ligne : https://doi.org/10.1007/s10803-021-05126-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder / Oren MIRON in Autism Research, 14-1 (January 2021)
[article]
Titre : Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Oren MIRON, Auteur ; Rafael E. DELGADO, Auteur ; Christine F. DELGADO, Auteur ; Elizabeth A. SIMPSON, Auteur ; Kun-Hsing YU, Auteur ; Anibal GUTIERREZ, Auteur ; Guangyu ZENG, Auteur ; Jillian N. GERSTENBERGER, Auteur ; Isaac S. KOHANE, Auteur Article en page(s) : p.46-52 Langues : Anglais (eng) Mots-clés : auditory biomarker children event-related potential infants Index. décimale : PER Périodiques Résumé : Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD. We found that the ASD newborns had significant prolongations of their ABR phase and V-negative latency compared with the non-ASD newborns. Newborns in the ASD group also exhibited greater variance in their latencies compared to previous studies in older ASD samples, likely due in part to the low intensity of the ABR stimulus. These findings suggest that newborns display neurophysiological variation associated with ASD at birth. Future studies with higher-intensity stimulus ABRs may allow more accurate predictions of ASD risk, which could augment the universal ABR test that currently screens millions of newborns worldwide. LAY SUMMARY: Children with autism spectrum disorder (ASD) have slow brain responses to sounds. We examined these brain responses from newborns' hearing tests and found that newborns who were later diagnosed with autism also had slower brain responses to sounds. Future studies might use these findings to better predict autism risk, with a hearing test that is already used on millions of newborns worldwide. En ligne : http://dx.doi.org/10.1002/aur.2422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-1 (January 2021) . - p.46-52[article] Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Oren MIRON, Auteur ; Rafael E. DELGADO, Auteur ; Christine F. DELGADO, Auteur ; Elizabeth A. SIMPSON, Auteur ; Kun-Hsing YU, Auteur ; Anibal GUTIERREZ, Auteur ; Guangyu ZENG, Auteur ; Jillian N. GERSTENBERGER, Auteur ; Isaac S. KOHANE, Auteur . - p.46-52.
Langues : Anglais (eng)
in Autism Research > 14-1 (January 2021) . - p.46-52
Mots-clés : auditory biomarker children event-related potential infants Index. décimale : PER Périodiques Résumé : Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD. We found that the ASD newborns had significant prolongations of their ABR phase and V-negative latency compared with the non-ASD newborns. Newborns in the ASD group also exhibited greater variance in their latencies compared to previous studies in older ASD samples, likely due in part to the low intensity of the ABR stimulus. These findings suggest that newborns display neurophysiological variation associated with ASD at birth. Future studies with higher-intensity stimulus ABRs may allow more accurate predictions of ASD risk, which could augment the universal ABR test that currently screens millions of newborns worldwide. LAY SUMMARY: Children with autism spectrum disorder (ASD) have slow brain responses to sounds. We examined these brain responses from newborns' hearing tests and found that newborns who were later diagnosed with autism also had slower brain responses to sounds. Future studies might use these findings to better predict autism risk, with a hearing test that is already used on millions of newborns worldwide. En ligne : http://dx.doi.org/10.1002/aur.2422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441