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Auteur Mehdi GHOLAM |
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Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study / Dominique RUDAZ in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)
[article]
Titre : Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study Type de document : Texte imprimé et/ou numérique Auteurs : Dominique RUDAZ, Auteur ; Caroline L. VANDELEUR, Auteur ; Mehdi GHOLAM, Auteur ; Enrique CASTELAO, Auteur ; Marie-Pierre F. STRIPPOLI, Auteur ; Pierre MARQUET, Auteur ; Jean-Michel AUBRY, Auteur ; Kathleen R. MERIKANGAS, Auteur ; Martin PREISIG, Auteur Article en page(s) : p.404-413 Langues : Anglais (eng) Mots-clés : Mood disorders anxiety disorders drug misuse offspring of bipolar parents offspring of depressed parents precursors Index. décimale : PER Périodiques Résumé : BACKGROUND: There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders. METHODS: Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years. RESULTS: Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD. CONCLUSIONS: The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD. En ligne : http://dx.doi.org/10.1111/jcpp.13307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.404-413[article] Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study [Texte imprimé et/ou numérique] / Dominique RUDAZ, Auteur ; Caroline L. VANDELEUR, Auteur ; Mehdi GHOLAM, Auteur ; Enrique CASTELAO, Auteur ; Marie-Pierre F. STRIPPOLI, Auteur ; Pierre MARQUET, Auteur ; Jean-Michel AUBRY, Auteur ; Kathleen R. MERIKANGAS, Auteur ; Martin PREISIG, Auteur . - p.404-413.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.404-413
Mots-clés : Mood disorders anxiety disorders drug misuse offspring of bipolar parents offspring of depressed parents precursors Index. décimale : PER Périodiques Résumé : BACKGROUND: There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders. METHODS: Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years. RESULTS: Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD. CONCLUSIONS: The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD. En ligne : http://dx.doi.org/10.1111/jcpp.13307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445