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Auteur Carla COMACCHIO |
Documents disponibles écrits par cet auteur (1)
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Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9-year chart review study / Lorenzo BASSANI ; Marco GARZITTO ; Marco LAMBERTI ; Alessandro SIMONATI ; Francesca DARRA ; Sagnik BHATTACHARYYA ; Carla COMACCHIO ; Matteo BALESTRIERI ; Donatella ARCANGELI ; Marco COLIZZI in Autism Research, 16-11 (November 2023)
[article]
Titre : Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9-year chart review study Type de document : Texte imprimé et/ou numérique Auteurs : Lorenzo BASSANI, Auteur ; Marco GARZITTO, Auteur ; Marco LAMBERTI, Auteur ; Alessandro SIMONATI, Auteur ; Francesca DARRA, Auteur ; Sagnik BHATTACHARYYA, Auteur ; Carla COMACCHIO, Auteur ; Matteo BALESTRIERI, Auteur ; Donatella ARCANGELI, Auteur ; Marco COLIZZI, Auteur Article en page(s) : p.2139-2149 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Psychosocial stressors have been suggested to precipitate psychotic episodes in patients with pre-existing psychosis and otherwise healthy subjects. However, such a risk has never been formally investigated in individuals with autism spectrum disorder (ASD). Sixty-nine autistic adolescents hospitalized for psychotic/manic symptoms (PSY) and other mental health issues (NPSY) over a 9-year period were compared with reference to their previous exposure to psychosocial stressors. ASD diagnoses satisfied the International Classification of Diseases (ICD)-10 criteria. Psychotic/manic symptom assessment followed the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Psychosocial stressor exposure was collected separately at each admission. Preliminarily, univariate between-group comparisons were conducted. Then, a binomial model was adopted to investigate associations with previous exposure to psychosocial stressors. Results were reported with a change in AIC (?AIC). PSY patients presented with higher previous exposure to adverse life events (30.43% vs. 6.52%, OR=6.079 [1.209, 40.926], p=0.013) and school/work difficulties (30.43% vs. 8.70%, OR=4.478 [0.984, 23.846], p=0.034) than NPSY ones. Admissions for psychotic/manic symptoms occurred more likely in the context of family disturbances (OR=2.275 [1.045, 5.045], p=0.030) and adverse life events (OR=3.489 [1.194, 11.161], p=0.014). The fitted binomial model was found to be significant compared to the random effects model (?AIC=?1.962; ?210=21.96, p=0.015), with the risk of presenting psychotic/manic symptoms being increased by family disturbances (z=+4.118) and school/work difficulties (z=+2.455). The results suggest a potential psychosis-inducing effect of psychosocial stressors in ASD, which has clinical and policy implications. En ligne : https://doi.org/10.1002/aur.3042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517
in Autism Research > 16-11 (November 2023) . - p.2139-2149[article] Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9-year chart review study [Texte imprimé et/ou numérique] / Lorenzo BASSANI, Auteur ; Marco GARZITTO, Auteur ; Marco LAMBERTI, Auteur ; Alessandro SIMONATI, Auteur ; Francesca DARRA, Auteur ; Sagnik BHATTACHARYYA, Auteur ; Carla COMACCHIO, Auteur ; Matteo BALESTRIERI, Auteur ; Donatella ARCANGELI, Auteur ; Marco COLIZZI, Auteur . - p.2139-2149.
Langues : Anglais (eng)
in Autism Research > 16-11 (November 2023) . - p.2139-2149
Index. décimale : PER Périodiques Résumé : Abstract Psychosocial stressors have been suggested to precipitate psychotic episodes in patients with pre-existing psychosis and otherwise healthy subjects. However, such a risk has never been formally investigated in individuals with autism spectrum disorder (ASD). Sixty-nine autistic adolescents hospitalized for psychotic/manic symptoms (PSY) and other mental health issues (NPSY) over a 9-year period were compared with reference to their previous exposure to psychosocial stressors. ASD diagnoses satisfied the International Classification of Diseases (ICD)-10 criteria. Psychotic/manic symptom assessment followed the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Psychosocial stressor exposure was collected separately at each admission. Preliminarily, univariate between-group comparisons were conducted. Then, a binomial model was adopted to investigate associations with previous exposure to psychosocial stressors. Results were reported with a change in AIC (?AIC). PSY patients presented with higher previous exposure to adverse life events (30.43% vs. 6.52%, OR=6.079 [1.209, 40.926], p=0.013) and school/work difficulties (30.43% vs. 8.70%, OR=4.478 [0.984, 23.846], p=0.034) than NPSY ones. Admissions for psychotic/manic symptoms occurred more likely in the context of family disturbances (OR=2.275 [1.045, 5.045], p=0.030) and adverse life events (OR=3.489 [1.194, 11.161], p=0.014). The fitted binomial model was found to be significant compared to the random effects model (?AIC=?1.962; ?210=21.96, p=0.015), with the risk of presenting psychotic/manic symptoms being increased by family disturbances (z=+4.118) and school/work difficulties (z=+2.455). The results suggest a potential psychosis-inducing effect of psychosocial stressors in ASD, which has clinical and policy implications. En ligne : https://doi.org/10.1002/aur.3042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517