[article]
Titre : |
Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Frederike SCHIRMBECK, Auteur ; Marcella RIETSCHEL, Auteur ; Sven CICHON, Auteur ; Markus M. NOTHEN, Auteur ; Peter PROPPING, Auteur ; Wolfgang MAIER, Auteur ; Johannes SCHUMACHER, Auteur ; Rami ABOU JAMRA, Auteur ; Per HOFFMANN, Auteur ; Stefan HERMS, Auteur ; Thomas W. MÜHLEISEN, Auteur ; Katja V. BOESSHENZ, Auteur ; Christine SCHMAEL, Auteur ; Jana STROHMAIER, Auteur ; Alexander GEORGI, Auteur ; Thomas G. SCHULZE, Auteur |
Année de publication : |
2008 |
Article en page(s) : |
p.1977-1981 |
Langues : |
Anglais (eng) |
Mots-clés : |
Premorbid-functioning Susceptibility-genes Haplotypes Phenotype-dissection Complex-genetics Endophenotype |
Index. décimale : |
PER Périodiques |
Résumé : |
Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831–838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA. |
En ligne : |
http://dx.doi.org/10.1007/s10803-008-0582-6 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642 |
in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1977-1981
[article] Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin [Texte imprimé et/ou numérique] / Frederike SCHIRMBECK, Auteur ; Marcella RIETSCHEL, Auteur ; Sven CICHON, Auteur ; Markus M. NOTHEN, Auteur ; Peter PROPPING, Auteur ; Wolfgang MAIER, Auteur ; Johannes SCHUMACHER, Auteur ; Rami ABOU JAMRA, Auteur ; Per HOFFMANN, Auteur ; Stefan HERMS, Auteur ; Thomas W. MÜHLEISEN, Auteur ; Katja V. BOESSHENZ, Auteur ; Christine SCHMAEL, Auteur ; Jana STROHMAIER, Auteur ; Alexander GEORGI, Auteur ; Thomas G. SCHULZE, Auteur . - 2008 . - p.1977-1981. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1977-1981
Mots-clés : |
Premorbid-functioning Susceptibility-genes Haplotypes Phenotype-dissection Complex-genetics Endophenotype |
Index. décimale : |
PER Périodiques |
Résumé : |
Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831–838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA. |
En ligne : |
http://dx.doi.org/10.1007/s10803-008-0582-6 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642 |
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