[article]
Titre : |
Hypothesis: The Role of Sterols in Autism Spectrum Disorder |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Ryan W. Y. LEE, Auteur ; Elaine TIERNEY, Auteur |
Année de publication : |
2011 |
Article en page(s) : |
7 p. |
Langues : |
Anglais (eng) |
Index. décimale : |
PER Périodiques |
Résumé : |
A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed. Advances in genetic technology coupled with discoveries in membrane physiology have led to renewed interest for lipids in the nervous system. This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS. Impaired sonic hedgehog patterning, alterations in membrane lipid rafts leading to abnormal synaptic plasticity, and impaired neurosteroid synthesis are discussed. Potential therapeutic agents include the development of neuroactive steroid-based agents and enzyme-specific drugs. Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by utilizing advanced imaging and molecular techniques. |
En ligne : |
http://dx.doi.org/10.1155/2011/653570 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131 |
in Autism Research and Treatment > (February 2011) . - 7 p.
[article] Hypothesis: The Role of Sterols in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Ryan W. Y. LEE, Auteur ; Elaine TIERNEY, Auteur . - 2011 . - 7 p. Langues : Anglais ( eng) in Autism Research and Treatment > (February 2011) . - 7 p.
Index. décimale : |
PER Périodiques |
Résumé : |
A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed. Advances in genetic technology coupled with discoveries in membrane physiology have led to renewed interest for lipids in the nervous system. This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS. Impaired sonic hedgehog patterning, alterations in membrane lipid rafts leading to abnormal synaptic plasticity, and impaired neurosteroid synthesis are discussed. Potential therapeutic agents include the development of neuroactive steroid-based agents and enzyme-specific drugs. Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by utilizing advanced imaging and molecular techniques. |
En ligne : |
http://dx.doi.org/10.1155/2011/653570 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131 |
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