[article]
Titre : |
High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Naghi MOMENI, Auteur ; Lars BRUDIN, Auteur ; Fatemeh BEHNIA, Auteur ; Berit NORDSTROM, Auteur ; Ali YOSEFI-OUDARJI, Auteur ; Bengt SIVBERG, Auteur ; Mohammad T. JOGHATAEI, Auteur ; Bengt L. PERSSON, Auteur |
Année de publication : |
2011 |
Article en page(s) : |
6 p. |
Langues : |
Anglais (eng) |
Index. décimale : |
PER Périodiques |
Résumé : |
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD. |
En ligne : |
http://dx.doi.org/10.1155/2012/868576 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 |
in Autism Research and Treatment > (August 2011) . - 6 p.
[article] High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Naghi MOMENI, Auteur ; Lars BRUDIN, Auteur ; Fatemeh BEHNIA, Auteur ; Berit NORDSTROM, Auteur ; Ali YOSEFI-OUDARJI, Auteur ; Bengt SIVBERG, Auteur ; Mohammad T. JOGHATAEI, Auteur ; Bengt L. PERSSON, Auteur . - 2011 . - 6 p. Langues : Anglais ( eng) in Autism Research and Treatment > (August 2011) . - 6 p.
Index. décimale : |
PER Périodiques |
Résumé : |
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD. |
En ligne : |
http://dx.doi.org/10.1155/2012/868576 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 |
|