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Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder / Kenneth D. GADOW in Journal of Autism and Developmental Disorders, 40-9 (September 2010)
[article]
Titre : Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur Année de publication : 2010 Article en page(s) : p.1139-1145 Langues : Anglais (eng) Mots-clés : Autism Autism-spectrum-disorder SLC1A1 Obsessive–compulsive-behaviors Separation-anxiety Generalized-anxiety Index. décimale : PER Périodiques Résumé : Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples. En ligne : http://dx.doi.org/10.1007/s10803-010-0961-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108
in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1139-1145[article] Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur . - 2010 . - p.1139-1145.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1139-1145
Mots-clés : Autism Autism-spectrum-disorder SLC1A1 Obsessive–compulsive-behaviors Separation-anxiety Generalized-anxiety Index. décimale : PER Périodiques Résumé : Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples. En ligne : http://dx.doi.org/10.1007/s10803-010-0961-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108