6 recherche sur le mot-clé 'Dementia'

Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011-2019 / Samuel B. ROSENBERG ; Josue Antonio G. ESTRADA ; Marcia Pescador JIMENEZ ; Ashley SCOTT ; Alianna HIGGINS ; Eric RUBENSTEIN in Autism Research, 18-5 (May 2025)  

Public ISBD [article]  inAutism Research > 18-5 (May 2025) . - p.1077-1086 Titre : Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011-2019 Type de document : texte imprimé Auteurs : Samuel B. ROSENBERG, Auteur ; Josue Antonio G. ESTRADA, Auteur ; Marcia Pescador JIMENEZ, Auteur ; Ashley SCOTT, Auteur ; Alianna HIGGINS, Auteur ; Eric RUBENSTEIN, Auteur Article en page(s) : p.1077-1086 Langues : Anglais (eng) Mots-clés : Alzheimer disease  autism  dementia  disparity  epidemiology  intellectual disability  medicaid  medicare Index. décimale : PER Périodiques Résumé : ABSTRACT Alzheimer's disease and related dementias (ADRD) are burdensome and lethal conditions that have been hypothesized to be related to autism through shared genetic etiologies and environmental risk factors. Our objective was to use longitudinal Medicaid and Medicare data to describe the epidemiology of ADRD in publicly insured autistic adults. We used all claims and encounters from 2011 to 2019 to identify autism and ADRD. We calculated prevalence, incidence, age at onset, and created survival curves. There were 90,229 autistic adults ? 30 years of age and enrolled for at least 1 year in Medicaid and/or Medicare and 267 ADRD cases. Prevalence of ADRD was 2.09% (95% CI: 1.99%, 2.20%) in 2011 and 8.11% (95% CI: 7.92%, 8.30%) in 2019. Mean age at ADRD onset was 59.3 years (SD: 14.2). Mean age among men was 58.3 years (SD: 13.8) and 61.0 years among females. Incidence of ADRD was higher in autistic adults with intellectual disability with no difference by sex. ADRD is a prevalent condition in middle- and older-aged adults identified with autism in the Medicaid and Medicare system. Understanding the diagnostic process and phenotype of ADRD will be important to improve identification and treatment. En ligne : https://doi.org/10.1002/aur.70035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011-2019 [texte imprimé] / Samuel B. ROSENBERG, Auteur ; Josue Antonio G. ESTRADA, Auteur ; Marcia Pescador JIMENEZ, Auteur ; Ashley SCOTT, Auteur ; Alianna HIGGINS, Auteur ; Eric RUBENSTEIN, Auteur . - p.1077-1086. Langues : Anglais (eng) in Autism Research > 18-5 (May 2025) . - p.1077-1086 Mots-clés : Alzheimer disease  autism  dementia  disparity  epidemiology  intellectual disability  medicaid  medicare Index. décimale : PER Périodiques Résumé : ABSTRACT Alzheimer's disease and related dementias (ADRD) are burdensome and lethal conditions that have been hypothesized to be related to autism through shared genetic etiologies and environmental risk factors. Our objective was to use longitudinal Medicaid and Medicare data to describe the epidemiology of ADRD in publicly insured autistic adults. We used all claims and encounters from 2011 to 2019 to identify autism and ADRD. We calculated prevalence, incidence, age at onset, and created survival curves. There were 90,229 autistic adults ? 30 years of age and enrolled for at least 1 year in Medicaid and/or Medicare and 267 ADRD cases. Prevalence of ADRD was 2.09% (95% CI: 1.99%, 2.20%) in 2011 and 8.11% (95% CI: 7.92%, 8.30%) in 2019. Mean age at ADRD onset was 59.3 years (SD: 14.2). Mean age among men was 58.3 years (SD: 13.8) and 61.0 years among females. Incidence of ADRD was higher in autistic adults with intellectual disability with no difference by sex. ADRD is a prevalent condition in middle- and older-aged adults identified with autism in the Medicaid and Medicare system. Understanding the diagnostic process and phenotype of ADRD will be important to improve identification and treatment. En ligne : https://doi.org/10.1002/aur.70035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

A national survey of caregivers’ perspective of early symptoms of dementia among adults with an intellectual disability based on the DSQIID scale / Jin-Ding LIN in Research in Autism Spectrum Disorders, 8-3 (March 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-3 (March 2014) . - p.275-280 Titre : A national survey of caregivers’ perspective of early symptoms of dementia among adults with an intellectual disability based on the DSQIID scale Type de document : texte imprimé Auteurs : Jin-Ding LIN, Auteur ; Lan-Ping LIN, Auteur ; Yi-Chen HSIA, Auteur ; Shang-Wei HSU, Auteur ; Chia-Ling WU, Auteur ; Cordia M. CHU, Auteur Article en page(s) : p.275-280 Langues : Anglais (eng) Mots-clés : Intellectual disability  Aging  Caregiver  Dementia  DSQIID Index. décimale : PER Périodiques Résumé : Abstract As life expectancy increases for persons with an intellectual disability, concerns have been raised that there will be an increased demand for health or social services, particularly to address the challenges posed by the problems of dementia. To plan services for people with an intellectual disability who might experience the consequences of aging, an important first step is to obtain epidemiological data on the prevalence of dementia in this vulnerable population. This study aimed to investigate the dementia prevalence rate and its associated demographical factors in adults with an intellectual disability in Taiwan. A national survey was conducted to recruit 460 community residents of at least 45 years of age with an intellectual disability. The Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) was administered to caregivers to determine the symptoms of dementia in adults with an intellectual disability. The results indicated that 16.5% of the adults with an intellectual disability might have dementia conditions (DSQIID score ≧ 20). After controlling for other factors in a multiple logistic regression analysis, the older adults with intellectual disability (≧55 vs. 45–54, OR = 2.594, 95% CI = 1.438–4.679) and those individuals with a comorbid diagnosis of mental illness or neurological disease (with vs. without, OR = 2.826, 95% CI = 1.593–5.012) had a higher risk of dementia than their counterparts. This study suggests that further longitudinal studies are needed to examine the specific aspects of the functions of living and morbidity that might be affected by aging and concomitant conditions in adults with an intellectual disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224 [article] A national survey of caregivers’ perspective of early symptoms of dementia among adults with an intellectual disability based on the DSQIID scale [texte imprimé] / Jin-Ding LIN, Auteur ; Lan-Ping LIN, Auteur ; Yi-Chen HSIA, Auteur ; Shang-Wei HSU, Auteur ; Chia-Ling WU, Auteur ; Cordia M. CHU, Auteur . - p.275-280. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-3 (March 2014) . - p.275-280 Mots-clés : Intellectual disability  Aging  Caregiver  Dementia  DSQIID Index. décimale : PER Périodiques Résumé : Abstract As life expectancy increases for persons with an intellectual disability, concerns have been raised that there will be an increased demand for health or social services, particularly to address the challenges posed by the problems of dementia. To plan services for people with an intellectual disability who might experience the consequences of aging, an important first step is to obtain epidemiological data on the prevalence of dementia in this vulnerable population. This study aimed to investigate the dementia prevalence rate and its associated demographical factors in adults with an intellectual disability in Taiwan. A national survey was conducted to recruit 460 community residents of at least 45 years of age with an intellectual disability. The Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) was administered to caregivers to determine the symptoms of dementia in adults with an intellectual disability. The results indicated that 16.5% of the adults with an intellectual disability might have dementia conditions (DSQIID score ≧ 20). After controlling for other factors in a multiple logistic regression analysis, the older adults with intellectual disability (≧55 vs. 45–54, OR = 2.594, 95% CI = 1.438–4.679) and those individuals with a comorbid diagnosis of mental illness or neurological disease (with vs. without, OR = 2.826, 95% CI = 1.593–5.012) had a higher risk of dementia than their counterparts. This study suggests that further longitudinal studies are needed to examine the specific aspects of the functions of living and morbidity that might be affected by aging and concomitant conditions in adults with an intellectual disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224

Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS) / Giles MY TAN in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.42 Titre : Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS) Type de document : texte imprimé Auteurs : Giles MY TAN, Auteur ; Felix BEACHER, Auteur ; Eileen DALY, Auteur ; Jamie HORDER, Auteur ; Verinder PRASHER, Auteur ; Maria-Luisa HANNEY, Auteur ; Robin D. MORRIS, Auteur ; Simon LOVESTONE, Auteur ; Kieran C. MURPHY, Auteur ; Andrew SIMMONS, Auteur ; Declan G.M. MURPHY, Auteur Article en page(s) : p.42 Langues : Anglais (eng) Mots-clés : 1h mrs  Alzheimer's disease  Dementia  Down syndrome  Glutamate-glutamine (Glx)  Hippocampus  Intellectual disability  Magnetic resonance spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS), or trisomy 21, is one of the most common autosomal mutations. People with DS have intellectual disability (ID) and are at significantly increased risk of developing Alzheimer's disease (AD). The biological associates of both ID and AD in DS are poorly understood, but glutamate has been proposed to play a key role. In non-DS populations, glutamate is essential to learning and memory and glutamate-mediated excitotoxicity has been implicated in AD. However, the concentration of hippocampal glutamate in DS individuals with and without dementia has not previously been directly investigated. Proton magnetic resonance spectroscopy ((1)H MRS) can be used to measure in vivo the concentrations of glutamate-glutamine (Glx). The objective of the current study was to examine the hippocampal Glx concentration in non-demented DS (DS-) and demented DS (DS+) individuals. METHODS: We examined 46 adults with DS (35 without dementia and 11 with dementia) and 39 healthy controls (HC) using (1)H MRS and measured their hippocampal Glx concentrations. RESULTS: There was no significant difference in the hippocampal Glx concentration between DS+ and DS-, or between either of the DS groups and the healthy controls. Also, within DS, there was no significant correlation between hippocampal Glx concentration and measures of overall cognitive ability. Last, a sample size calculation based on the effect sizes from this study showed that it would have required 6,257 participants to provide 80% power to detect a significant difference between the groups which would indicate that there is a very low likelihood of a type 2 error accounting for the findings in this study. CONCLUSIONS: Individuals with DS do not have clinically detectable differences in hippocampal Glx concentration. Other pathophysiological processes likely account for ID and AD in people with DS. En ligne : http://dx.doi.org/10.1186/1866-1955-6-42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS) [texte imprimé] / Giles MY TAN, Auteur ; Felix BEACHER, Auteur ; Eileen DALY, Auteur ; Jamie HORDER, Auteur ; Verinder PRASHER, Auteur ; Maria-Luisa HANNEY, Auteur ; Robin D. MORRIS, Auteur ; Simon LOVESTONE, Auteur ; Kieran C. MURPHY, Auteur ; Andrew SIMMONS, Auteur ; Declan G.M. MURPHY, Auteur . - p.42. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.42 Mots-clés : 1h mrs  Alzheimer's disease  Dementia  Down syndrome  Glutamate-glutamine (Glx)  Hippocampus  Intellectual disability  Magnetic resonance spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS), or trisomy 21, is one of the most common autosomal mutations. People with DS have intellectual disability (ID) and are at significantly increased risk of developing Alzheimer's disease (AD). The biological associates of both ID and AD in DS are poorly understood, but glutamate has been proposed to play a key role. In non-DS populations, glutamate is essential to learning and memory and glutamate-mediated excitotoxicity has been implicated in AD. However, the concentration of hippocampal glutamate in DS individuals with and without dementia has not previously been directly investigated. Proton magnetic resonance spectroscopy ((1)H MRS) can be used to measure in vivo the concentrations of glutamate-glutamine (Glx). The objective of the current study was to examine the hippocampal Glx concentration in non-demented DS (DS-) and demented DS (DS+) individuals. METHODS: We examined 46 adults with DS (35 without dementia and 11 with dementia) and 39 healthy controls (HC) using (1)H MRS and measured their hippocampal Glx concentrations. RESULTS: There was no significant difference in the hippocampal Glx concentration between DS+ and DS-, or between either of the DS groups and the healthy controls. Also, within DS, there was no significant correlation between hippocampal Glx concentration and measures of overall cognitive ability. Last, a sample size calculation based on the effect sizes from this study showed that it would have required 6,257 participants to provide 80% power to detect a significant difference between the groups which would indicate that there is a very low likelihood of a type 2 error accounting for the findings in this study. CONCLUSIONS: Individuals with DS do not have clinically detectable differences in hippocampal Glx concentration. Other pathophysiological processes likely account for ID and AD in people with DS. En ligne : http://dx.doi.org/10.1186/1866-1955-6-42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Ageing and subjective cognitive decline in males and females: Associations with objective cognitive abilities, mental health, and autistic traits / Andrea TALES ; Emma RICHARDS ; Alecia L. COUSINS ; Julia R. BADGER in Research in Autism, 127 (September 2025)  

Public ISBD [article]  inResearch in Autism > 127 (September 2025) . - p.202682 Titre : Ageing and subjective cognitive decline in males and females: Associations with objective cognitive abilities, mental health, and autistic traits Type de document : texte imprimé Auteurs : Andrea TALES, Auteur ; Emma RICHARDS, Auteur ; Alecia L. COUSINS, Auteur ; Julia R. BADGER, Auteur Article en page(s) : p.202682 Langues : Anglais (eng) Mots-clés : Ageing  Dementia  SCD  Mental health  Sex  Autistic traits  Autism Index. décimale : PER Périodiques En ligne : https://doi.org/10.1016/j.reia.2025.202682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Ageing and subjective cognitive decline in males and females: Associations with objective cognitive abilities, mental health, and autistic traits [texte imprimé] / Andrea TALES, Auteur ; Emma RICHARDS, Auteur ; Alecia L. COUSINS, Auteur ; Julia R. BADGER, Auteur . - p.202682. Langues : Anglais (eng) in Research in Autism > 127 (September 2025) . - p.202682 Mots-clés : Ageing  Dementia  SCD  Mental health  Sex  Autistic traits  Autism Index. décimale : PER Périodiques En ligne : https://doi.org/10.1016/j.reia.2025.202682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568