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Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? / Paul ASHWOOD in Journal of Autism and Developmental Disorders, 38-1 (January 2008)
[article]
Titre : Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? Type de document : Texte imprimé et/ou numérique Auteurs : Paul ASHWOOD, Auteur ; Christina KWONG, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Paula KRAKOWIAK, Auteur ; Wynn WALKER, Auteur ; Isaac N. PESSAH, Auteur ; Judy VAN DE WATER, Auteur ; David J. HANSEN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2008 Article en page(s) : p.169-175 Langues : Anglais (eng) Mots-clés : Inflammation Leptin Autism Regression Index. décimale : PER Périodiques Résumé : There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group.
En ligne : http://dx.doi.org/10.1007/s10803-006-0353-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316
in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.169-175[article] Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? [Texte imprimé et/ou numérique] / Paul ASHWOOD, Auteur ; Christina KWONG, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Paula KRAKOWIAK, Auteur ; Wynn WALKER, Auteur ; Isaac N. PESSAH, Auteur ; Judy VAN DE WATER, Auteur ; David J. HANSEN, Auteur ; Lisa A. CROEN, Auteur . - 2008 . - p.169-175.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.169-175
Mots-clés : Inflammation Leptin Autism Regression Index. décimale : PER Périodiques Résumé : There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group.
En ligne : http://dx.doi.org/10.1007/s10803-006-0353-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316