1 recherche sur le mot-clé 'MRPL19'

Language Impairment and Dyslexia Genes Influence Language Skills in Children With Autism Spectrum Disorders / John D. EICHER in Autism Research, 8-2 (April 2015)  

Public ISBD [article]  inAutism Research > 8-2 (April 2015) . - p.229-234 Titre : Language Impairment and Dyslexia Genes Influence Language Skills in Children With Autism Spectrum Disorders Type de document : texte imprimé Auteurs : John D. EICHER, Auteur ; Jeffrey R. GRUEN, Auteur Article en page(s) : p.229-234 Langues : Anglais (eng) Mots-clés : language  autism spectrum disorders  ATP2C2  MRPL19  dyslexia  language impairment Index. décimale : PER Périodiques Résumé : Language and communication development is a complex process influenced by numerous environmental and genetic factors. Many neurodevelopment disorders include deficits in language and communication skills in their diagnostic criteria, including autism spectrum disorders (ASD), language impairment (LI), and dyslexia. These disorders are polygenic and complex with a significant genetic component contributing to each. The similarity of language phenotypes and comorbidity of these disorders suggest that they may share genetic contributors. To test this, we examined the association of genes previously implicated in dyslexia, LI, and/or language-related traits with language skills in children with ASD. We used genetic and language data collected in the Autism Genome Research Exchange (AGRE) and Simons Simplex Collection (SSC) cohorts to perform a meta-analysis on performance on a receptive vocabulary task. There were associations with LI risk gene ATP2C2 and dyslexia risk gene MRPL19. Additionally, we found suggestive evidence of association with CMIP, GCFC2, KIAA0319L, the DYX2 locus (ACOT13, GPLD1, and FAM65B), and DRD2. Our results show that LI and dyslexia genes also contribute to language traits in children with ASD. These associations add to the growing literature of generalist genes that contribute to multiple related neurobehavioral traits. Future studies should examine whether other genetic contributors may be shared among these disorders and how risk variants interact with each other and the environment to modify clinical presentations. En ligne : http://dx.doi.org/10.1002/aur.1436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Language Impairment and Dyslexia Genes Influence Language Skills in Children With Autism Spectrum Disorders [texte imprimé] / John D. EICHER, Auteur ; Jeffrey R. GRUEN, Auteur . - p.229-234. Langues : Anglais (eng) in Autism Research > 8-2 (April 2015) . - p.229-234 Mots-clés : language  autism spectrum disorders  ATP2C2  MRPL19  dyslexia  language impairment Index. décimale : PER Périodiques Résumé : Language and communication development is a complex process influenced by numerous environmental and genetic factors. Many neurodevelopment disorders include deficits in language and communication skills in their diagnostic criteria, including autism spectrum disorders (ASD), language impairment (LI), and dyslexia. These disorders are polygenic and complex with a significant genetic component contributing to each. The similarity of language phenotypes and comorbidity of these disorders suggest that they may share genetic contributors. To test this, we examined the association of genes previously implicated in dyslexia, LI, and/or language-related traits with language skills in children with ASD. We used genetic and language data collected in the Autism Genome Research Exchange (AGRE) and Simons Simplex Collection (SSC) cohorts to perform a meta-analysis on performance on a receptive vocabulary task. There were associations with LI risk gene ATP2C2 and dyslexia risk gene MRPL19. Additionally, we found suggestive evidence of association with CMIP, GCFC2, KIAA0319L, the DYX2 locus (ACOT13, GPLD1, and FAM65B), and DRD2. Our results show that LI and dyslexia genes also contribute to language traits in children with ASD. These associations add to the growing literature of generalist genes that contribute to multiple related neurobehavioral traits. Future studies should examine whether other genetic contributors may be shared among these disorders and how risk variants interact with each other and the environment to modify clinical presentations. En ligne : http://dx.doi.org/10.1002/aur.1436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256