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Increased Expression of miR-155p5 in Amygdala of Children With Autism Spectrum Disorder / Khulood Abdullah ALMEHMADI in Autism Research, 13-1 (January 2020)
[article]
Titre : Increased Expression of miR-155p5 in Amygdala of Children With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Khulood Abdullah ALMEHMADI, Auteur ; Irene TSILIONI, Auteur ; Theoharis C. THEOHARIDES, Auteur Article en page(s) : p.18-23 Langues : Anglais (eng) Mots-clés : Mir-155 autism spectrum disorder brain microRNAs neuroinflammation Index. décimale : PER Périodiques Résumé : MiR-155p5 is a pro-inflammatory microRNA reported to be involved in several neurol-inflammatory diseases. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social interactions and communication, as well as stereotypic movements. Inflammation of the brain due to activation of microglia has been reported in ASD. We investigated miR-155p5 gene expression in postmortem human brain tissues [amygdala and dorsolateral prefrontal cortex regions (DLPFC)]. There was significant increase of miR-155p5 in amygdala (P = 0.0001), but not in DLFC, in ASD children (n = 8) compared to non-ASD (n = 7) controls. The increased gene expression of miR-155p5 in amygdala of children of ASD support the presence of localized inflammation in the brain and indicates miR-155p5 may be targeted for therapy of ASD. Autism Res 2020, 13: 18-23. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The pathogenesis of autism spectrum disorder (ASD) is still unknown. Our data of increased gene expression of miR-155p5 in brains of children with ASD support the presence of localized inflammation in the amygdala and indicates that miR-155p5 may be targeted for therapy of ASD and other neurodegenerative diseases. En ligne : http://dx.doi.org/10.1002/aur.2205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Autism Research > 13-1 (January 2020) . - p.18-23[article] Increased Expression of miR-155p5 in Amygdala of Children With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Khulood Abdullah ALMEHMADI, Auteur ; Irene TSILIONI, Auteur ; Theoharis C. THEOHARIDES, Auteur . - p.18-23.
Langues : Anglais (eng)
in Autism Research > 13-1 (January 2020) . - p.18-23
Mots-clés : Mir-155 autism spectrum disorder brain microRNAs neuroinflammation Index. décimale : PER Périodiques Résumé : MiR-155p5 is a pro-inflammatory microRNA reported to be involved in several neurol-inflammatory diseases. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social interactions and communication, as well as stereotypic movements. Inflammation of the brain due to activation of microglia has been reported in ASD. We investigated miR-155p5 gene expression in postmortem human brain tissues [amygdala and dorsolateral prefrontal cortex regions (DLPFC)]. There was significant increase of miR-155p5 in amygdala (P = 0.0001), but not in DLFC, in ASD children (n = 8) compared to non-ASD (n = 7) controls. The increased gene expression of miR-155p5 in amygdala of children of ASD support the presence of localized inflammation in the brain and indicates miR-155p5 may be targeted for therapy of ASD. Autism Res 2020, 13: 18-23. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The pathogenesis of autism spectrum disorder (ASD) is still unknown. Our data of increased gene expression of miR-155p5 in brains of children with ASD support the presence of localized inflammation in the amygdala and indicates that miR-155p5 may be targeted for therapy of ASD and other neurodegenerative diseases. En ligne : http://dx.doi.org/10.1002/aur.2205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415