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Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation / N. M. GAGE in Journal of Neurodevelopmental Disorders, 1-3 (September 2009)
[article]
Titre : Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation Type de document : Texte imprimé et/ou numérique Auteurs : N. M. GAGE, Auteur ; J. JURANEK, Auteur ; P. A. FILIPEK, Auteur ; K. OSANN, Auteur ; P. FLODMAN, Auteur ; A. L. ISENBERG, Auteur ; M. A. SPENCE, Auteur Article en page(s) : p.205-14 Langues : Anglais (eng) Mots-clés : Auditory cortex Developmental disorder Heschl's gyrus Language cortex Posterior superior temporal gyrus Index. décimale : PER Périodiques Résumé : PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. METHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals. RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-009-9010-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341
in Journal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.205-14[article] Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation [Texte imprimé et/ou numérique] / N. M. GAGE, Auteur ; J. JURANEK, Auteur ; P. A. FILIPEK, Auteur ; K. OSANN, Auteur ; P. FLODMAN, Auteur ; A. L. ISENBERG, Auteur ; M. A. SPENCE, Auteur . - p.205-14.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.205-14
Mots-clés : Auditory cortex Developmental disorder Heschl's gyrus Language cortex Posterior superior temporal gyrus Index. décimale : PER Périodiques Résumé : PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. METHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals. RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-009-9010-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341