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Editorial: Data repositories, registries, and standards in the search for valid and reproducible biomarkers / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)
[article]
Titre : Editorial: Data repositories, registries, and standards in the search for valid and reproducible biomarkers Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur Article en page(s) : p.929-931 Langues : Anglais (eng) Mots-clés : repositories registries standards biomarkers imaging Index. décimale : PER Périodiques Résumé : The paucity of major scientific breakthroughs leading to new or improved treatments, and the inability to identify valid and reproducible biomarkers that improve clinical management, has produced a crisis in confidence in the validity of our pathogenic theories and the reproducibility of our research findings. This crisis in turn has driven changes in standards for research methodologies and prompted calls for the creation of open-access data repositories and the preregistration of research hypotheses. Although we should embrace the creation of repositories and registries, and the promise for greater statistical power, reproducibility, and generalizability of research findings they afford, we should also recognize that they alone are no substitute for sound design in minimizing study confounds, and they are no guarantor of faith in the validity of our pathogenic theories, findings, and biomarkers. One way, and maybe the only sure way, of knowing that we have a valid understanding of brain processes and disease mechanisms in human studies is by experimentally manipulating variables and predicting its effects on outcome measures and biomarkers. En ligne : https://doi.org/10.1111/jcpp.12962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.929-931[article] Editorial: Data repositories, registries, and standards in the search for valid and reproducible biomarkers [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur . - p.929-931.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.929-931
Mots-clés : repositories registries standards biomarkers imaging Index. décimale : PER Périodiques Résumé : The paucity of major scientific breakthroughs leading to new or improved treatments, and the inability to identify valid and reproducible biomarkers that improve clinical management, has produced a crisis in confidence in the validity of our pathogenic theories and the reproducibility of our research findings. This crisis in turn has driven changes in standards for research methodologies and prompted calls for the creation of open-access data repositories and the preregistration of research hypotheses. Although we should embrace the creation of repositories and registries, and the promise for greater statistical power, reproducibility, and generalizability of research findings they afford, we should also recognize that they alone are no substitute for sound design in minimizing study confounds, and they are no guarantor of faith in the validity of our pathogenic theories, findings, and biomarkers. One way, and maybe the only sure way, of knowing that we have a valid understanding of brain processes and disease mechanisms in human studies is by experimentally manipulating variables and predicting its effects on outcome measures and biomarkers. En ligne : https://doi.org/10.1111/jcpp.12962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368