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Auteur Ian H. GOTLIB |
Documents disponibles écrits par cet auteur (17)
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5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls / Corina BENJET in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)
[article]
Titre : 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls Type de document : Texte imprimé et/ou numérique Auteurs : Corina BENJET, Auteur ; Renee THOMPSON, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2010 Article en page(s) : p.173-179 Langues : Anglais (eng) Mots-clés : Peer-victimization bullying depression genetic-polymorphisms 5-HTTLPR Index. décimale : PER Périodiques Résumé : Background: Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls.
Methods: Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory.
Results: The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles.
Conclusions: The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02149.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.173-179[article] 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls [Texte imprimé et/ou numérique] / Corina BENJET, Auteur ; Renee THOMPSON, Auteur ; Ian H. GOTLIB, Auteur . - 2010 . - p.173-179.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.173-179
Mots-clés : Peer-victimization bullying depression genetic-polymorphisms 5-HTTLPR Index. décimale : PER Périodiques Résumé : Background: Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls.
Methods: Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory.
Results: The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles.
Conclusions: The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02149.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 Affective and physiological responses to stress in girls at elevated risk for depression / Christian E. WAUGH in Development and Psychopathology, 24-2 (May 2012)
[article]
Titre : Affective and physiological responses to stress in girls at elevated risk for depression Type de document : Texte imprimé et/ou numérique Auteurs : Christian E. WAUGH, Auteur ; Luma MUHTADIE, Auteur ; Renee THOMPSON, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2012 Article en page(s) : p.661-675 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents. En ligne : http://dx.doi.org/10.1017/S0954579412000235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Development and Psychopathology > 24-2 (May 2012) . - p.661-675[article] Affective and physiological responses to stress in girls at elevated risk for depression [Texte imprimé et/ou numérique] / Christian E. WAUGH, Auteur ; Luma MUHTADIE, Auteur ; Renee THOMPSON, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur . - 2012 . - p.661-675.
Langues : Anglais (eng)
in Development and Psychopathology > 24-2 (May 2012) . - p.661-675
Index. décimale : PER Périodiques Résumé : Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents. En ligne : http://dx.doi.org/10.1017/S0954579412000235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms / Rajpreet CHAHAL in Development and Psychopathology, 34-2 (May 2022)
[article]
Titre : An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Rajpreet CHAHAL, Auteur ; Jonas G. MILLER, Auteur ; Justin P. YUAN, Auteur ; Jessica L. BUTHMANN, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : 557-571 Langues : Anglais (eng) Mots-clés : adolescence adversity dimensions connectivity development Index. décimale : PER Périodiques Résumé : Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9?19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579421001814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-2 (May 2022) . - 557-571[article] An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms [Texte imprimé et/ou numérique] / Rajpreet CHAHAL, Auteur ; Jonas G. MILLER, Auteur ; Justin P. YUAN, Auteur ; Jessica L. BUTHMANN, Auteur ; Ian H. GOTLIB, Auteur . - 557-571.
Langues : Anglais (eng)
in Development and Psychopathology > 34-2 (May 2022) . - 557-571
Mots-clés : adolescence adversity dimensions connectivity development Index. décimale : PER Périodiques Résumé : Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9?19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579421001814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning / Kathryn L. HUMPHREYS in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)
[article]
Titre : Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn L. HUMPHREYS, Auteur ; Katharina KIRCANSKI, Auteur ; Natalie L. COLICH, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1174-1182 Langues : Anglais (eng) Mots-clés : Early life stress attentional bias fearful faces social problems Index. décimale : PER Périodiques Résumé : Background Early life stress is associated with poorer social functioning. Attentional biases in response to threat-related cues, linked to both early experience and psychopathology, may explain this association. To date, however, no study has examined attentional biases to fearful facial expressions as a function of early life stress or examined these biases as a potential mediator of the relation between early life stress and social problems. Methods In a sample of 154 children (ages 9–13 years) we examined the associations among interpersonal early life stressors (i.e., birth through age 6 years), attentional biases to emotional facial expressions using a dot-probe task, and social functioning on the Child Behavior Checklist. Results High levels of early life stress were associated with both greater levels of social problems and an attentional bias away from fearful facial expressions, even after accounting for stressors occurring in later childhood. No biases were found for happy or sad facial expressions as a function of early life stress. Finally, attentional biases to fearful faces mediated the association between early life stress and social problems. Conclusions Attentional avoidance of fearful facial expressions, evidenced by a bias away from these stimuli, may be a developmental response to early adversity and link the experience of early life stress to poorer social functioning. En ligne : http://dx.doi.org/10.1111/jcpp.12607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1174-1182[article] Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning [Texte imprimé et/ou numérique] / Kathryn L. HUMPHREYS, Auteur ; Katharina KIRCANSKI, Auteur ; Natalie L. COLICH, Auteur ; Ian H. GOTLIB, Auteur . - p.1174-1182.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1174-1182
Mots-clés : Early life stress attentional bias fearful faces social problems Index. décimale : PER Périodiques Résumé : Background Early life stress is associated with poorer social functioning. Attentional biases in response to threat-related cues, linked to both early experience and psychopathology, may explain this association. To date, however, no study has examined attentional biases to fearful facial expressions as a function of early life stress or examined these biases as a potential mediator of the relation between early life stress and social problems. Methods In a sample of 154 children (ages 9–13 years) we examined the associations among interpersonal early life stressors (i.e., birth through age 6 years), attentional biases to emotional facial expressions using a dot-probe task, and social functioning on the Child Behavior Checklist. Results High levels of early life stress were associated with both greater levels of social problems and an attentional bias away from fearful facial expressions, even after accounting for stressors occurring in later childhood. No biases were found for happy or sad facial expressions as a function of early life stress. Finally, attentional biases to fearful faces mediated the association between early life stress and social problems. Conclusions Attentional avoidance of fearful facial expressions, evidenced by a bias away from these stimuli, may be a developmental response to early adversity and link the experience of early life stress to poorer social functioning. En ligne : http://dx.doi.org/10.1111/jcpp.12607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 Attentional bias training in girls at risk for depression / Joelle LEMOULT in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)
[article]
Titre : Attentional bias training in girls at risk for depression Type de document : Texte imprimé et/ou numérique Auteurs : Joelle LEMOULT, Auteur ; Jutta JOORMANN, Auteur ; Katharina KIRCANSKI, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1326-1333 Langues : Anglais (eng) Mots-clés : Attention bias modification depression adolescents Index. décimale : PER Périodiques Résumé : Background This study examined, for the first time, whether attentional biases can be modified in adolescents at risk for depression. Methods The final sample consisted of 41 girls at familial risk for depression, who were randomly assigned to receive six sessions (864 trials) of real or sham attention bias training [Real attentional bias training (ABT) vs. Sham ABT]. Participants who received Real ABT completed a modified dot-probe task designed to train attention toward positive and away from negative facial expressions; in contrast, girls who received Sham ABT completed the standard dot-probe task. Attentional biases, self-reported mood, and psychophysiological responses to stress were measured at pre- and post-training assessments. Results As expected, girls who received Real ABT, but not those who received Sham ABT, exhibited significant increases from pre- to post-training in their attention toward happy faces and away from sad faces. Moreover, adolescents who received Real ABT were buffered against the negative outcomes experienced by adolescents who received Sham ABT. Specifically, only adolescents who received Sham ABT experienced an increase in negative mood and a pre- to post-training increase in heart rate in anticipation of the stressor. Conclusions The current findings provide the first experimental evidence that attentional biases can be modified in youth at risk for depression and further suggest that ABT modulates the heightened response to stress that is otherwise experienced by high-risk adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.12587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1326-1333[article] Attentional bias training in girls at risk for depression [Texte imprimé et/ou numérique] / Joelle LEMOULT, Auteur ; Jutta JOORMANN, Auteur ; Katharina KIRCANSKI, Auteur ; Ian H. GOTLIB, Auteur . - p.1326-1333.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1326-1333
Mots-clés : Attention bias modification depression adolescents Index. décimale : PER Périodiques Résumé : Background This study examined, for the first time, whether attentional biases can be modified in adolescents at risk for depression. Methods The final sample consisted of 41 girls at familial risk for depression, who were randomly assigned to receive six sessions (864 trials) of real or sham attention bias training [Real attentional bias training (ABT) vs. Sham ABT]. Participants who received Real ABT completed a modified dot-probe task designed to train attention toward positive and away from negative facial expressions; in contrast, girls who received Sham ABT completed the standard dot-probe task. Attentional biases, self-reported mood, and psychophysiological responses to stress were measured at pre- and post-training assessments. Results As expected, girls who received Real ABT, but not those who received Sham ABT, exhibited significant increases from pre- to post-training in their attention toward happy faces and away from sad faces. Moreover, adolescents who received Real ABT were buffered against the negative outcomes experienced by adolescents who received Sham ABT. Specifically, only adolescents who received Sham ABT experienced an increase in negative mood and a pre- to post-training increase in heart rate in anticipation of the stressor. Conclusions The current findings provide the first experimental evidence that attentional biases can be modified in youth at risk for depression and further suggest that ABT modulates the heightened response to stress that is otherwise experienced by high-risk adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.12587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 Coping with having a depressed mother: The role of stress and coping in hypothalamic–pituitary–adrenal axis dysfunction in girls at familial risk for major depression / Lara C. FOLAND-ROSS in Development and Psychopathology, 26-4 (Part 2) (November 2014)
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