Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Haruhisa OHTA |
Documents disponibles écrits par cet auteur (6)
Faire une suggestion Affiner la recherche
Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder / Takashi ITAHASHI in Molecular Autism, (May 2015)
[article]
Titre : Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (May 2015) . - p.1-14[article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - p.1-14.
Langues : Anglais (eng)
in Molecular Autism > (May 2015) . - p.1-14
Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder / Haruhisa OHTA in Autism Research, 9-2 (February 2016)
[article]
Titre : Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Haruhisa OHTA, Auteur ; Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Aaron LEE, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.232-248 Langues : Anglais (eng) Mots-clés : cortical thickness surface area gray matter volume megalencephaly autism spectrum disorder FreeSurfer Index. décimale : PER Périodiques Résumé : The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (?3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n?=?17) were analyzed separately from the boys with normal brain size (ASD-N, n?=?95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. En ligne : http://dx.doi.org/10.1002/aur.1520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-2 (February 2016) . - p.232-248[article] Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Haruhisa OHTA, Auteur ; Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Aaron LEE, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.232-248.
Langues : Anglais (eng)
in Autism Research > 9-2 (February 2016) . - p.232-248
Mots-clés : cortical thickness surface area gray matter volume megalencephaly autism spectrum disorder FreeSurfer Index. décimale : PER Périodiques Résumé : The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (?3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n?=?17) were analyzed separately from the boys with normal brain size (ASD-N, n?=?95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. En ligne : http://dx.doi.org/10.1002/aur.1520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Recognition of Facial Expressions and Prosodic Cues with Graded Emotional Intensities in Adults with Asperger Syndrome / Hirokazu DOI in Journal of Autism and Developmental Disorders, 43-9 (September 2013)
[article]
Titre : Recognition of Facial Expressions and Prosodic Cues with Graded Emotional Intensities in Adults with Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Hirokazu DOI, Auteur ; Takashi X. FUJISAWA, Auteur ; Chieko KANAI, Auteur ; Haruhisa OHTA, Auteur ; Hideki YOKOI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Kazuyuki SHINOHARA, Auteur Article en page(s) : p.2099-2113 Langues : Anglais (eng) Mots-clés : Facial expression Prosody Inversion effect Configural processing Asperger syndrome Index. décimale : PER Périodiques Résumé : This study investigated the ability of adults with Asperger syndrome to recognize emotional categories of facial expressions and emotional prosodies with graded emotional intensities. The individuals with Asperger syndrome showed poorer recognition performance for angry and sad expressions from both facial and vocal information. The group difference in facial expression recognition was prominent for stimuli with low or intermediate emotional intensities. In contrast to this, the individuals with Asperger syndrome exhibited lower recognition accuracy than typically-developed controls mainly for emotional prosody with high emotional intensity. In facial expression recognition, Asperger and control groups showed an inversion effect for all categories. The magnitude of this effect was less in the Asperger group for angry and sad expressions, presumably attributable to reduced recruitment of the configural mode of face processing. The individuals with Asperger syndrome outperformed the control participants in recognizing inverted sad expressions, indicating enhanced processing of local facial information representing sad emotion. These results suggest that the adults with Asperger syndrome rely on modality-specific strategies in emotion recognition from facial expression and prosodic information. En ligne : http://dx.doi.org/10.1007/s10803-013-1760-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2099-2113[article] Recognition of Facial Expressions and Prosodic Cues with Graded Emotional Intensities in Adults with Asperger Syndrome [Texte imprimé et/ou numérique] / Hirokazu DOI, Auteur ; Takashi X. FUJISAWA, Auteur ; Chieko KANAI, Auteur ; Haruhisa OHTA, Auteur ; Hideki YOKOI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Kazuyuki SHINOHARA, Auteur . - p.2099-2113.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2099-2113
Mots-clés : Facial expression Prosody Inversion effect Configural processing Asperger syndrome Index. décimale : PER Périodiques Résumé : This study investigated the ability of adults with Asperger syndrome to recognize emotional categories of facial expressions and emotional prosodies with graded emotional intensities. The individuals with Asperger syndrome showed poorer recognition performance for angry and sad expressions from both facial and vocal information. The group difference in facial expression recognition was prominent for stimuli with low or intermediate emotional intensities. In contrast to this, the individuals with Asperger syndrome exhibited lower recognition accuracy than typically-developed controls mainly for emotional prosody with high emotional intensity. In facial expression recognition, Asperger and control groups showed an inversion effect for all categories. The magnitude of this effect was less in the Asperger group for angry and sad expressions, presumably attributable to reduced recruitment of the configural mode of face processing. The individuals with Asperger syndrome outperformed the control participants in recognizing inverted sad expressions, indicating enhanced processing of local facial information representing sad emotion. These results suggest that the adults with Asperger syndrome rely on modality-specific strategies in emotion recognition from facial expression and prosodic information. En ligne : http://dx.doi.org/10.1007/s10803-013-1760-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study / I-Fan LIN in Molecular Autism, (February 2014)
[article]
Titre : The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study Type de document : Texte imprimé et/ou numérique Auteurs : I-Fan LIN, Auteur ; Makio KASHINO, Auteur ; Haruhisa OHTA, Auteur ; Takashi YAMADA, Auteur ; Masayuki TANI, Auteur ; Hiromi WATANABE, Auteur ; Chieko KANAI, Auteur ; Taisei OHNO, Auteur ; Yuko TAKAYAMA, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorders (ASD) have difficulty with verbal communication, which might be due to a lack of spontaneous orientation toward social auditory stimuli. Previous studies have shown that a single dose of oxytocin improves speech comprehension in autism. The primary aim of this study was to investigate whether the orientation behaviors toward human sounds are different for neurotypical (NT) adults and adults with ASD and whether oxytocin has an effect on their orientation behaviors toward human sounds. This was a randomized, placebo-controlled, within-subject, crossover design study of intranasal oxytocin versus placebo in 13 NT adults and 16 adults with ASD. Subjects were randomized to 24 IU intranasal oxytocin or placebo on different days, and they were blind to the treatment. The participants then listened passively to human and non-human affective sounds while their skin conductance responses (SCRs) and the changes in peripheral blood vessel constriction were monitored as an indicator of spontaneous orientation. The monitored data were analyzed by a mixed-design ANOVA. Oxytocin enhanced the difference between the SCRs to human and non-human sounds in both the NT and ASD groups (F(1,56) = 6.046, p = 0.017). Further correlation coefficient analysis showed significant correlations between this SCR difference and the scores in the autism spectrum quotient 'attention to detail' and 'social skill' subscales and interpersonal reactivity index and social functioning scale in the ASD group. Oxytocin was well tolerated, and no serious adverse effects were reported. The difference in SCRs implies that oxytocin nasal spray may enhance orientation behaviors toward human sounds in the presence of other environmental sounds in both ASD and NT adults.Trial registration: UMIN-CTR Clinical Trial, Unique trial number: UMIN000005809 En ligne : http://dx.doi.org/10.1186/2040-2392-5-20 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (February 2014)[article] The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study [Texte imprimé et/ou numérique] / I-Fan LIN, Auteur ; Makio KASHINO, Auteur ; Haruhisa OHTA, Auteur ; Takashi YAMADA, Auteur ; Masayuki TANI, Auteur ; Hiromi WATANABE, Auteur ; Chieko KANAI, Auteur ; Taisei OHNO, Auteur ; Yuko TAKAYAMA, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (February 2014)
Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorders (ASD) have difficulty with verbal communication, which might be due to a lack of spontaneous orientation toward social auditory stimuli. Previous studies have shown that a single dose of oxytocin improves speech comprehension in autism. The primary aim of this study was to investigate whether the orientation behaviors toward human sounds are different for neurotypical (NT) adults and adults with ASD and whether oxytocin has an effect on their orientation behaviors toward human sounds. This was a randomized, placebo-controlled, within-subject, crossover design study of intranasal oxytocin versus placebo in 13 NT adults and 16 adults with ASD. Subjects were randomized to 24 IU intranasal oxytocin or placebo on different days, and they were blind to the treatment. The participants then listened passively to human and non-human affective sounds while their skin conductance responses (SCRs) and the changes in peripheral blood vessel constriction were monitored as an indicator of spontaneous orientation. The monitored data were analyzed by a mixed-design ANOVA. Oxytocin enhanced the difference between the SCRs to human and non-human sounds in both the NT and ASD groups (F(1,56) = 6.046, p = 0.017). Further correlation coefficient analysis showed significant correlations between this SCR difference and the scores in the autism spectrum quotient 'attention to detail' and 'social skill' subscales and interpersonal reactivity index and social functioning scale in the ASD group. Oxytocin was well tolerated, and no serious adverse effects were reported. The difference in SCRs implies that oxytocin nasal spray may enhance orientation behaviors toward human sounds in the presence of other environmental sounds in both ASD and NT adults.Trial registration: UMIN-CTR Clinical Trial, Unique trial number: UMIN000005809 En ligne : http://dx.doi.org/10.1186/2040-2392-5-20 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 Transdiagnostic and sex differences in cognitive profiles of autism spectrum disorder and attention-deficit/hyperactivity disorder / Hirokazu DOI in Autism Research, 15-6 (June 2022)
[article]
Titre : Transdiagnostic and sex differences in cognitive profiles of autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hirokazu DOI, Auteur ; Chieko KANAI, Auteur ; Haruhisa OHTA, Auteur Article en page(s) : p.1130-1141 Langues : Anglais (eng) Mots-clés : Adult Attention Deficit Disorder with Hyperactivity/complications/diagnosis/epidemiology Autism Spectrum Disorder/psychology Cognition Female Humans Male Sex Characteristics Wechsler Scales Adhd Asd Wais cognitive profile sex difference Index. décimale : PER Périodiques Résumé : An increasing number of studies have shown that autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share symptoms and aetiologies. However, transdiagnostic comparisons between ASD and ADHD is complicated due to the sex differences within each condition. To clarify the similarities and differences in the cognitive functioning between ASD and ADHD, while considering potential sex differences, this study compared cognitive profiles assessed by the WAIS-III between the four groups created by orthogonally combining diagnosis and sex based on the data from 277 ASD males, 86 ASD females, 99 ADHD males and 64 ADHD females. The analysis revealed three major findings. First, performance IQ and perceptual organization index were higher in ADHD males than in ASD males and ADHD females. Second, Gaussian mixture model fitting revealed two clusters underlying the distribution of subindex scores. The percentage of being classified into the cluster that scored lower in all the subindices was higher in females than in males irrespective of diagnosis. Third, feature importance for classification of ASD and ADHD yielded by random forest classifier, a supervised machine learning algorithm, revealed that autism quotient was most informative feature in classifying ASD and ADHD in males, while the discrepancy between verbal and performance intelligence quotient was in females, indicating that the set of behavioral features contributing to classification differs between males and females. Thus, these findings indicate that sex as well as diagnosis is critical in determining the cognitive profiles of people with ASD and ADHD. LAY SUMMARY: The present study compared profiles of cognitive functions measured by Wechsler Adult Intelligence Scale between males and females with ASD and ADHD. The analyses revealed clear sex differences in cognitive functions in both ASD and ADHD and that the set of cognitive functions useful in classifying ASD and ADHD differed between males and females. Thus, biological sex seems to be a critical factor in determining the cognitive profiles of people with ASD and ADHD. En ligne : http://dx.doi.org/10.1002/aur.2712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-6 (June 2022) . - p.1130-1141[article] Transdiagnostic and sex differences in cognitive profiles of autism spectrum disorder and attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Hirokazu DOI, Auteur ; Chieko KANAI, Auteur ; Haruhisa OHTA, Auteur . - p.1130-1141.
Langues : Anglais (eng)
in Autism Research > 15-6 (June 2022) . - p.1130-1141
Mots-clés : Adult Attention Deficit Disorder with Hyperactivity/complications/diagnosis/epidemiology Autism Spectrum Disorder/psychology Cognition Female Humans Male Sex Characteristics Wechsler Scales Adhd Asd Wais cognitive profile sex difference Index. décimale : PER Périodiques Résumé : An increasing number of studies have shown that autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share symptoms and aetiologies. However, transdiagnostic comparisons between ASD and ADHD is complicated due to the sex differences within each condition. To clarify the similarities and differences in the cognitive functioning between ASD and ADHD, while considering potential sex differences, this study compared cognitive profiles assessed by the WAIS-III between the four groups created by orthogonally combining diagnosis and sex based on the data from 277 ASD males, 86 ASD females, 99 ADHD males and 64 ADHD females. The analysis revealed three major findings. First, performance IQ and perceptual organization index were higher in ADHD males than in ASD males and ADHD females. Second, Gaussian mixture model fitting revealed two clusters underlying the distribution of subindex scores. The percentage of being classified into the cluster that scored lower in all the subindices was higher in females than in males irrespective of diagnosis. Third, feature importance for classification of ASD and ADHD yielded by random forest classifier, a supervised machine learning algorithm, revealed that autism quotient was most informative feature in classifying ASD and ADHD in males, while the discrepancy between verbal and performance intelligence quotient was in females, indicating that the set of behavioral features contributing to classification differs between males and females. Thus, these findings indicate that sex as well as diagnosis is critical in determining the cognitive profiles of people with ASD and ADHD. LAY SUMMARY: The present study compared profiles of cognitive functions measured by Wechsler Adult Intelligence Scale between males and females with ASD and ADHD. The analyses revealed clear sex differences in cognitive functions in both ASD and ADHD and that the set of cognitive functions useful in classifying ASD and ADHD differed between males and females. Thus, biological sex seems to be a critical factor in determining the cognitive profiles of people with ASD and ADHD. En ligne : http://dx.doi.org/10.1002/aur.2712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile / Haruhisa OHTA in Molecular Autism, 11 (2020)
Permalink