Abnormalities in brain systems supporting individuation and enumeration in autism / Kirsten O'HEARN in Autism Research, 9-1 (January 2016)  

Public ISBD [article]  inAutism Research > 9-1 (January 2016) . - p.82-96 Titre : Abnormalities in brain systems supporting individuation and enumeration in autism Type de document : Texte imprimé et/ou numérique Auteurs : Kirsten O'HEARN, Auteur ; Katerina VELANOVA, Auteur ; Andrew LYNN, Auteur ; Catherine WRIGHT, Auteur ; Michael HALLQUIST, Auteur ; Nancy MINSHEW, Auteur ; Beatriz LUNA, Auteur Article en page(s) : p.82-96 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  fMRI  parietal  number  subitizing  counting Index. décimale : PER Périodiques Résumé : Previous work indicates that adults with autism display a decreased capacity when rapidly enumerating small sets of elements (i.e., subitizing), compared to typically developing (TD) individuals. This ability is crucial for fundamental visual functions such as object individuation and parallel processing. Thus, the deficit in autism suggests limits in these skills. To examine the neural basis of this limitation, adults with and without high functioning autism rapidly enumerated 1 to 8 randomly located squares during a neuroimaging study. Typically, adults are thought to use parallel visual processes to quantify up to three or four elements, and serial processes to enumerate more (5+) elements. We hypothesized that parietal lobe regions associated with counting would be recruited with smaller sets of elements in adults with autism, compared to TD adults. Consistent with this hypothesis, activation in parietal regions increased with smaller set sizes in adults with autism compared to TD adults. Increased activation for three elements was evident in several regions, including those thought to underlie subitizing. In addition, regions specific to the counting range in TD adults were often equally active for set sizes in the subitizing range in the adults with autism. Finally, significant deactivation was evident in TD adults, presumably reflecting relative suppression of regions specialized for competing processes, but was not apparent in adults with autism. These differences in brain function in adults with autism on a simple enumeration task suggest atypical brain organization and function that is likely to impact most visual tasks, especially those with multiple elements. En ligne : http://dx.doi.org/10.1002/aur.1498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Abnormalities in brain systems supporting individuation and enumeration in autism [Texte imprimé et/ou numérique] / Kirsten O'HEARN, Auteur ; Katerina VELANOVA, Auteur ; Andrew LYNN, Auteur ; Catherine WRIGHT, Auteur ; Michael HALLQUIST, Auteur ; Nancy MINSHEW, Auteur ; Beatriz LUNA, Auteur . - p.82-96. Langues : Anglais (eng) in Autism Research > 9-1 (January 2016) . - p.82-96 Mots-clés : autism spectrum disorder  fMRI  parietal  number  subitizing  counting Index. décimale : PER Périodiques Résumé : Previous work indicates that adults with autism display a decreased capacity when rapidly enumerating small sets of elements (i.e., subitizing), compared to typically developing (TD) individuals. This ability is crucial for fundamental visual functions such as object individuation and parallel processing. Thus, the deficit in autism suggests limits in these skills. To examine the neural basis of this limitation, adults with and without high functioning autism rapidly enumerated 1 to 8 randomly located squares during a neuroimaging study. Typically, adults are thought to use parallel visual processes to quantify up to three or four elements, and serial processes to enumerate more (5+) elements. We hypothesized that parietal lobe regions associated with counting would be recruited with smaller sets of elements in adults with autism, compared to TD adults. Consistent with this hypothesis, activation in parietal regions increased with smaller set sizes in adults with autism compared to TD adults. Increased activation for three elements was evident in several regions, including those thought to underlie subitizing. In addition, regions specific to the counting range in TD adults were often equally active for set sizes in the subitizing range in the adults with autism. Finally, significant deactivation was evident in TD adults, presumably reflecting relative suppression of regions specialized for competing processes, but was not apparent in adults with autism. These differences in brain function in adults with autism on a simple enumeration task suggest atypical brain organization and function that is likely to impact most visual tasks, especially those with multiple elements. En ligne : http://dx.doi.org/10.1002/aur.1498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Cortical Variability in the Sensory-Evoked Response in Autism / Sarah M. HAIGH in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1176-1190 Titre : Cortical Variability in the Sensory-Evoked Response in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarah M. HAIGH, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Nancy MINSHEW, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.1176-1190 Langues : Anglais (eng) Mots-clés : Autism  fMRI  Sensory-evoked  Variability Index. décimale : PER Périodiques Résumé : Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2276-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Cortical Variability in the Sensory-Evoked Response in Autism [Texte imprimé et/ou numérique] / Sarah M. HAIGH, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Nancy MINSHEW, Auteur ; Marlene BEHRMANN, Auteur . - p.1176-1190. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1176-1190 Mots-clés : Autism  fMRI  Sensory-evoked  Variability Index. décimale : PER Périodiques Résumé : Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2276-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Developmental Changes in Brain Function Underlying Inhibitory Control in Autism Spectrum Disorders / Aarthi PADMANABHAN in Autism Research, 8-2 (April 2015)  

Public ISBD [article]  inAutism Research > 8-2 (April 2015) . - p.123-135 Titre : Developmental Changes in Brain Function Underlying Inhibitory Control in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Aarthi PADMANABHAN, Auteur ; Krista GARVER, Auteur ; Kirsten O'HEARN, Auteur ; Natalie NAWARAWONG, Auteur ; Ran LIU, Auteur ; Nancy MINSHEW, Auteur ; John SWEENEY, Auteur ; Beatriz LUNA, Auteur Article en page(s) : p.123-135 Langues : Anglais (eng) Mots-clés : autism  fMRI  inhibitory control  antisaccade  development  adolescence Index. décimale : PER Périodiques Résumé : The development of inhibitory control—the ability to suppress inappropriate actions in order to make goal-directed responses—is often impaired in autism spectrum disorders (ASD). In the present study, we examined whether the impairments in inhibitory control evident in ASD reflect—in part—differences in the development of the neural substrates of inhibitory control from adolescence into adulthood. We conducted a functional magnetic resonance imaging (fMRI) study on the anti-saccade task, a probe of inhibitory control, in high-functioning adolescents and adults with ASD compared to a matched group of typically developing (TD) individuals. The ASD group did not show the age-related improvements in behavioral performance from adolescence to adulthood evident in the typical group, consistent with previous behavioral work. The fMRI results indicated that much of the circuitry recruited by the ASD group was similar to the TD group. However, the ASD group demonstrated some unique patterns, including: (a) a failure to recruit the frontal eye field during response preparation in adolescence but comparable recruitment in adulthood; (b) greater recruitment of putamen in adolescence and precuneus in adolescence and adulthood than the TD group; and (c) decreased recruitment in the inferior parietal lobule relative to TD groups. Taken together, these results suggest that brain circuitry underlying inhibitory control develops differently from adolescence to adulthood in ASD. Specifically, there may be relative underdevelopment of brain processes underlying inhibitory control in ASD, which may lead to engagement of subcortical compensatory processes. En ligne : http://dx.doi.org/10.1002/aur.1398 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Developmental Changes in Brain Function Underlying Inhibitory Control in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Aarthi PADMANABHAN, Auteur ; Krista GARVER, Auteur ; Kirsten O'HEARN, Auteur ; Natalie NAWARAWONG, Auteur ; Ran LIU, Auteur ; Nancy MINSHEW, Auteur ; John SWEENEY, Auteur ; Beatriz LUNA, Auteur . - p.123-135. Langues : Anglais (eng) in Autism Research > 8-2 (April 2015) . - p.123-135 Mots-clés : autism  fMRI  inhibitory control  antisaccade  development  adolescence Index. décimale : PER Périodiques Résumé : The development of inhibitory control—the ability to suppress inappropriate actions in order to make goal-directed responses—is often impaired in autism spectrum disorders (ASD). In the present study, we examined whether the impairments in inhibitory control evident in ASD reflect—in part—differences in the development of the neural substrates of inhibitory control from adolescence into adulthood. We conducted a functional magnetic resonance imaging (fMRI) study on the anti-saccade task, a probe of inhibitory control, in high-functioning adolescents and adults with ASD compared to a matched group of typically developing (TD) individuals. The ASD group did not show the age-related improvements in behavioral performance from adolescence to adulthood evident in the typical group, consistent with previous behavioral work. The fMRI results indicated that much of the circuitry recruited by the ASD group was similar to the TD group. However, the ASD group demonstrated some unique patterns, including: (a) a failure to recruit the frontal eye field during response preparation in adolescence but comparable recruitment in adulthood; (b) greater recruitment of putamen in adolescence and precuneus in adolescence and adulthood than the TD group; and (c) decreased recruitment in the inferior parietal lobule relative to TD groups. Taken together, these results suggest that brain circuitry underlying inhibitory control develops differently from adolescence to adulthood in ASD. Specifically, there may be relative underdevelopment of brain processes underlying inhibitory control in ASD, which may lead to engagement of subcortical compensatory processes. En ligne : http://dx.doi.org/10.1002/aur.1398 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Duane F. Alexander, M.D.: August 11, 1940-February 16, 2020 / Fred R. VOLKMAR in Journal of Autism and Developmental Disorders, 50-7 (July 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2641-2642 Titre : Duane F. Alexander, M.D.: August 11, 1940-February 16, 2020 Type de document : Texte imprimé et/ou numérique Auteurs : Fred R. VOLKMAR, Auteur ; Geraldine DAWSON, Auteur ; Rebecca LAND, Auteur ; Catherine LORD, Auteur ; Katherine A. LOVELAND, Auteur ; William MCMAHON, Auteur ; Nancy MINSHEW, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.2641-2642 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04534-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Duane F. Alexander, M.D.: August 11, 1940-February 16, 2020 [Texte imprimé et/ou numérique] / Fred R. VOLKMAR, Auteur ; Geraldine DAWSON, Auteur ; Rebecca LAND, Auteur ; Catherine LORD, Auteur ; Katherine A. LOVELAND, Auteur ; William MCMAHON, Auteur ; Nancy MINSHEW, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.2641-2642. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2641-2642 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04534-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Over-Responsiveness and Greater Variability in Roughness Perception in Autism / Sarah M. HAIGH in Autism Research, 9-3 (March 2016)  

Public ISBD [article]  inAutism Research > 9-3 (March 2016) . - p.393-402 Titre : Over-Responsiveness and Greater Variability in Roughness Perception in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarah M. HAIGH, Auteur ; Nancy MINSHEW, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.393-402 Langues : Anglais (eng) Mots-clés : autism  tactile  variability  sensory hypersensitivity Index. décimale : PER Périodiques Résumé : Although sensory problems, including tactile hypersensitivity and hyposensitivity (DSM-5) are commonly associated with autism, there is a dearth of systematic and rigorous research in this domain. Here, we report findings from a psychophysical experiment that explored differences in tactile perception between individuals with autism and typically developing control participants, who, using their index finger, rated a series of surfaces on the extent of their roughness. Each surface was rated multiple times and we calculated both the average rating and the variability across trials. Relative to controls, the individuals with autism perceived the surfaces as rougher overall and exhibited greater variability in their ratings across trials. These findings characterize altered tactile perception in autism and suggest that sensory problems in autism may be the product of overly responsive and variable sensory processing. Autism Res 2016, 9: 393–402. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Over-Responsiveness and Greater Variability in Roughness Perception in Autism [Texte imprimé et/ou numérique] / Sarah M. HAIGH, Auteur ; Nancy MINSHEW, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Marlene BEHRMANN, Auteur . - p.393-402. Langues : Anglais (eng) in Autism Research > 9-3 (March 2016) . - p.393-402 Mots-clés : autism  tactile  variability  sensory hypersensitivity Index. décimale : PER Périodiques Résumé : Although sensory problems, including tactile hypersensitivity and hyposensitivity (DSM-5) are commonly associated with autism, there is a dearth of systematic and rigorous research in this domain. Here, we report findings from a psychophysical experiment that explored differences in tactile perception between individuals with autism and typically developing control participants, who, using their index finger, rated a series of surfaces on the extent of their roughness. Each surface was rated multiple times and we calculated both the average rating and the variability across trials. Relative to controls, the individuals with autism perceived the surfaces as rougher overall and exhibited greater variability in their ratings across trials. These findings characterize altered tactile perception in autism and suggest that sensory problems in autism may be the product of overly responsive and variable sensory processing. Autism Res 2016, 9: 393–402. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Sensory Processing in Autism / Marlene BEHRMANN in Key Issues in Mental Health, 180 (2015)

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The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder / Paul HERSCU in Journal of Autism and Developmental Disorders, 50-9 (September 2020)  

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Therapeutic Horseback Riding Outcomes of Parent-Identified Goals for Children with Autism Spectrum Disorder: An ABA? Multiple Case Design Examining Dosing and Generalization to the Home and Community / Margo B. HOLM in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

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