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9-1 - January 2016 [Texte imprimé et/ou numérique] . - 2016. Langues : Anglais (eng)
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Code-barres | Cote | Support | Localisation | Section | Disponibilité |
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PER0001441 | PER ARE | Périodique | Centre d'Information et de Documentation du CRA Rhône-Alpes | PER - Périodiques | Exclu du prêt |
Dépouillements


[article]
Titre : AUR Reviewer Thank You 2015 Type de document : Texte imprimé et/ou numérique Article en page(s) : p.5-8 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.5-8[article] AUR Reviewer Thank You 2015 [Texte imprimé et/ou numérique] . - p.5-8.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.5-8
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 The landscape of copy number variations in Finnish families with autism spectrum disorders / Chakravarthi KANDURI in Autism Research, 9-1 (January 2016)
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[article]
Titre : The landscape of copy number variations in Finnish families with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Chakravarthi KANDURI, Auteur ; Katri KANTOJARVI, Auteur ; Paula M. SALO, Auteur ; Raija VANHALA, Auteur ; Gemma BUCK, Auteur ; Christine BLANCHER, Auteur ; Harri LÄHDESMÄKI, Auteur ; Irma JARVELA, Auteur Article en page(s) : p.9-16 Langues : Anglais (eng) Mots-clés : autism spectrum disorders copy number variations Finnish population genome wide SNP arrays Index. décimale : PER Périodiques Résumé : Rare de novo and inherited copy number variations (CNVs) have been implicated in autism spectrum disorder (ASD) risk. However, the genetic underpinnings of ASD remain unknown in more than 80% of cases. Therefore, identification of novel candidate genes and corroboration of known candidate genes may broaden the horizons of determining genetic risk alleles, and subsequent development of diagnostic testing. Here, using genotyping arrays, we characterized the genetic architecture of rare CNVs (<1% frequency) in a Finnish case–control dataset. Unsurprisingly, ASD cases harbored a significant excess of rare, large (>1 Mb) CNVs and rare, exonic CNVs. The exonic rare de novo CNV rate (?22.5%) seemed higher compared to previous reports. We identified several CNVs in well-known ASD regions including GSTM1-5, DISC1, FHIT, RBFOX1, CHRNA7, 15q11.2, 15q13.2-q13.3, 17q12, and 22q11.21. Additionally, several novel candidate genes (BDKRB1, BDKRB2, AP2M1, SPTA1, PTH1R, CYP2E1, PLCD3, F2RL1, UQCRC2, LILRB3, RPS9, and COL11A2) were identified through gene prioritization. The majority of these genes belong to neuroactive ligand–receptor interaction pathways, and calcium signaling pathways, thus suggesting that a subset of these novel candidate genes may contribute to ASD risk. Furthermore, several metabolic pathways like caffeine metabolism, drug metabolism, retinol metabolism, and calcium-signaling pathway were found to be affected by the rare exonic ASD CNVs. Additionally, biological processes such as bradykinin receptor activity, endoderm formation and development, and oxidoreductase activity were enriched among the rare exonic ASD CNVs. Overall, our findings may add data about new genes and pathways that contribute to the genetic architecture of ASD. En ligne : http://dx.doi.org/10.1002/aur.1502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.9-16[article] The landscape of copy number variations in Finnish families with autism spectrum disorders [Texte imprimé et/ou numérique] / Chakravarthi KANDURI, Auteur ; Katri KANTOJARVI, Auteur ; Paula M. SALO, Auteur ; Raija VANHALA, Auteur ; Gemma BUCK, Auteur ; Christine BLANCHER, Auteur ; Harri LÄHDESMÄKI, Auteur ; Irma JARVELA, Auteur . - p.9-16.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.9-16
Mots-clés : autism spectrum disorders copy number variations Finnish population genome wide SNP arrays Index. décimale : PER Périodiques Résumé : Rare de novo and inherited copy number variations (CNVs) have been implicated in autism spectrum disorder (ASD) risk. However, the genetic underpinnings of ASD remain unknown in more than 80% of cases. Therefore, identification of novel candidate genes and corroboration of known candidate genes may broaden the horizons of determining genetic risk alleles, and subsequent development of diagnostic testing. Here, using genotyping arrays, we characterized the genetic architecture of rare CNVs (<1% frequency) in a Finnish case–control dataset. Unsurprisingly, ASD cases harbored a significant excess of rare, large (>1 Mb) CNVs and rare, exonic CNVs. The exonic rare de novo CNV rate (?22.5%) seemed higher compared to previous reports. We identified several CNVs in well-known ASD regions including GSTM1-5, DISC1, FHIT, RBFOX1, CHRNA7, 15q11.2, 15q13.2-q13.3, 17q12, and 22q11.21. Additionally, several novel candidate genes (BDKRB1, BDKRB2, AP2M1, SPTA1, PTH1R, CYP2E1, PLCD3, F2RL1, UQCRC2, LILRB3, RPS9, and COL11A2) were identified through gene prioritization. The majority of these genes belong to neuroactive ligand–receptor interaction pathways, and calcium signaling pathways, thus suggesting that a subset of these novel candidate genes may contribute to ASD risk. Furthermore, several metabolic pathways like caffeine metabolism, drug metabolism, retinol metabolism, and calcium-signaling pathway were found to be affected by the rare exonic ASD CNVs. Additionally, biological processes such as bradykinin receptor activity, endoderm formation and development, and oxidoreductase activity were enriched among the rare exonic ASD CNVs. Overall, our findings may add data about new genes and pathways that contribute to the genetic architecture of ASD. En ligne : http://dx.doi.org/10.1002/aur.1502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice / Hadar SEGAL-GAVISH in Autism Research, 9-1 (January 2016)
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[article]
Titre : Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice Type de document : Texte imprimé et/ou numérique Auteurs : Hadar SEGAL-GAVISH, Auteur ; Golan KARVAT, Auteur ; Noy BARAK, Auteur ; Ran BARZILAY, Auteur ; Javier GANZ, Auteur ; Liat EDRY, Auteur ; Israel AHARONY, Auteur ; Daniel OFFEN, Auteur ; Tali KIMCHI, Auteur Article en page(s) : p.17-32 Langues : Anglais (eng) Mots-clés : BTBR animal model MSC BDNF neurogenesis Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are characterized by social communication deficits, cognitive rigidity, and repetitive stereotyped behaviors. Mesenchymal stem cells (MSC) have a paracrine regenerative effect, and were speculated to be a potential therapy for ASD. The BTBR inbred mouse strain is a commonly used model of ASD as it demonstrates robust behavioral deficits consistent with the diagnostic criteria for ASD. BTBR mice also exhibit decreased brain-derived neurotrophic factor (BDNF) signaling and reduced hippocampal neurogenesis. In the current study, we evaluated the behavioral and molecular effects of intracerebroventricular MSC transplantation in BTBR mice. Transplantation of MSC resulted in a reduction of stereotypical behaviors, a decrease in cognitive rigidity and an improvement in social behavior. Tissue analysis revealed elevated BDNF protein levels in the hippocampus accompanied by increased hippocampal neurogenesis in the MSC-transplanted mice compared with sham treated mice. This might indicate a possible mechanism underpinning the behavioral improvement. Our study suggests a novel therapeutic approach which may be translatable to ASD patients in the future. En ligne : http://dx.doi.org/10.1002/aur.1530 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.17-32[article] Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice [Texte imprimé et/ou numérique] / Hadar SEGAL-GAVISH, Auteur ; Golan KARVAT, Auteur ; Noy BARAK, Auteur ; Ran BARZILAY, Auteur ; Javier GANZ, Auteur ; Liat EDRY, Auteur ; Israel AHARONY, Auteur ; Daniel OFFEN, Auteur ; Tali KIMCHI, Auteur . - p.17-32.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.17-32
Mots-clés : BTBR animal model MSC BDNF neurogenesis Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are characterized by social communication deficits, cognitive rigidity, and repetitive stereotyped behaviors. Mesenchymal stem cells (MSC) have a paracrine regenerative effect, and were speculated to be a potential therapy for ASD. The BTBR inbred mouse strain is a commonly used model of ASD as it demonstrates robust behavioral deficits consistent with the diagnostic criteria for ASD. BTBR mice also exhibit decreased brain-derived neurotrophic factor (BDNF) signaling and reduced hippocampal neurogenesis. In the current study, we evaluated the behavioral and molecular effects of intracerebroventricular MSC transplantation in BTBR mice. Transplantation of MSC resulted in a reduction of stereotypical behaviors, a decrease in cognitive rigidity and an improvement in social behavior. Tissue analysis revealed elevated BDNF protein levels in the hippocampus accompanied by increased hippocampal neurogenesis in the MSC-transplanted mice compared with sham treated mice. This might indicate a possible mechanism underpinning the behavioral improvement. Our study suggests a novel therapeutic approach which may be translatable to ASD patients in the future. En ligne : http://dx.doi.org/10.1002/aur.1530 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder / K. Alexandra HAVDAHL in Autism Research, 9-1 (January 2016)
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[article]
Titre : Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. Alexandra HAVDAHL, Auteur ; Stephen VON TETZCHNER, Auteur ; Marisela HUERTA, Auteur ; Catherine LORD, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.33-42 Langues : Anglais (eng) Mots-clés : early detection diagnosis emotional/behavioral problems Child Behavior Checklist (CBCL) Index. décimale : PER Périodiques Résumé : The Child Behavior Checklist (CBCL) has been proposed for screening of autism spectrum disorders (ASD) in clinical settings. Given the already widespread use of the CBCL, this could have great implications for clinical practice. This study examined the utility of CBCL profiles in differentiating children with ASD from children with other clinical disorders. Participants were 226 children with ASD and 163 children with attention-deficit/hyperactivity disorder, intellectual disability, language disorders, or emotional disorders, aged 2–13 years. Diagnosis was based on comprehensive clinical evaluation including well-validated diagnostic instruments for ASD and cognitive testing. Discriminative validity of CBCL profiles proposed for ASD screening was examined with area under the curve (AUC) scores, sensitivity, and specificity. The CBCL profiles showed low discriminative accuracy for ASD (AUC 0.59–0.70). Meeting cutoffs proposed for ASD was associated with general emotional/behavioral problems (EBP; mood problems/aggressive behavior), both in children with and without ASD. Cutoff adjustment depending on EBP-level was associated with improved discriminative accuracy for school-age children. However, the rate of false positives remained high in children with clinical levels of EBP. The results indicate that use of the CBCL profiles for ASD-specific screening would likely result in a large number of misclassifications. Although taking EBP-level into account was associated with improved discriminative accuracy for ASD, acceptable specificity could only be achieved for school-age children with below clinical levels of EBP. Further research should explore the potential of using the EBP adjustment strategy to improve the screening efficiency of other more ASD-specific instruments. En ligne : http://dx.doi.org/10.1002/aur.1515 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.33-42[article] Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. Alexandra HAVDAHL, Auteur ; Stephen VON TETZCHNER, Auteur ; Marisela HUERTA, Auteur ; Catherine LORD, Auteur ; Somer L. BISHOP, Auteur . - p.33-42.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.33-42
Mots-clés : early detection diagnosis emotional/behavioral problems Child Behavior Checklist (CBCL) Index. décimale : PER Périodiques Résumé : The Child Behavior Checklist (CBCL) has been proposed for screening of autism spectrum disorders (ASD) in clinical settings. Given the already widespread use of the CBCL, this could have great implications for clinical practice. This study examined the utility of CBCL profiles in differentiating children with ASD from children with other clinical disorders. Participants were 226 children with ASD and 163 children with attention-deficit/hyperactivity disorder, intellectual disability, language disorders, or emotional disorders, aged 2–13 years. Diagnosis was based on comprehensive clinical evaluation including well-validated diagnostic instruments for ASD and cognitive testing. Discriminative validity of CBCL profiles proposed for ASD screening was examined with area under the curve (AUC) scores, sensitivity, and specificity. The CBCL profiles showed low discriminative accuracy for ASD (AUC 0.59–0.70). Meeting cutoffs proposed for ASD was associated with general emotional/behavioral problems (EBP; mood problems/aggressive behavior), both in children with and without ASD. Cutoff adjustment depending on EBP-level was associated with improved discriminative accuracy for school-age children. However, the rate of false positives remained high in children with clinical levels of EBP. The results indicate that use of the CBCL profiles for ASD-specific screening would likely result in a large number of misclassifications. Although taking EBP-level into account was associated with improved discriminative accuracy for ASD, acceptable specificity could only be achieved for school-age children with below clinical levels of EBP. Further research should explore the potential of using the EBP adjustment strategy to improve the screening efficiency of other more ASD-specific instruments. En ligne : http://dx.doi.org/10.1002/aur.1515 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation / Dina R. DAJANI in Autism Research, 9-1 (January 2016)
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[article]
Titre : Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation Type de document : Texte imprimé et/ou numérique Auteurs : Dina R. DAJANI, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.43-54 Langues : Anglais (eng) Mots-clés : autism brain development resting state functional MRI regional homogeneity Index. décimale : PER Périodiques Résumé : There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here, we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel's timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross-sectional design. Resting-state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adolescents, and adults. In typical development, ReHo across the entire brain was higher in children than in adolescents and adults. In contrast, children with ASD exhibited marginally lower ReHo than TD children, while adolescents and adults with ASD exhibited similar levels of local connectivity as age-matched neurotypical individuals. During all developmental stages, individuals with ASD exhibited lower local connectivity in sensory processing brain regions and higher local connectivity in complex information processing regions. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. These results demonstrate that local connectivity is disrupted in ASD across development, with the most pronounced differences occurring in childhood. Developmental changes in ReHo do not mirror findings from fMRI studies of long-range connectivity in ASD, pointing to a need for more nuanced accounts of brain connectivity alterations in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.43-54[article] Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation [Texte imprimé et/ou numérique] / Dina R. DAJANI, Auteur ; Lucina Q. UDDIN, Auteur . - p.43-54.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.43-54
Mots-clés : autism brain development resting state functional MRI regional homogeneity Index. décimale : PER Périodiques Résumé : There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here, we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel's timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross-sectional design. Resting-state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adolescents, and adults. In typical development, ReHo across the entire brain was higher in children than in adolescents and adults. In contrast, children with ASD exhibited marginally lower ReHo than TD children, while adolescents and adults with ASD exhibited similar levels of local connectivity as age-matched neurotypical individuals. During all developmental stages, individuals with ASD exhibited lower local connectivity in sensory processing brain regions and higher local connectivity in complex information processing regions. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. These results demonstrate that local connectivity is disrupted in ASD across development, with the most pronounced differences occurring in childhood. Developmental changes in ReHo do not mirror findings from fMRI studies of long-range connectivity in ASD, pointing to a need for more nuanced accounts of brain connectivity alterations in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism / Rajesh K. KANA in Autism Research, 9-1 (January 2016)
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[article]
Titre : Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Rajesh K. KANA, Auteur ; Michelle A. PATRIQUIN, Auteur ; Briley S. BLACK, Auteur ; Marie M. CHANNELL, Auteur ; Bruno WICKER, Auteur Article en page(s) : p.55-66 Langues : Anglais (eng) Mots-clés : implicit emotion explicit emotion fMRI functional connectivity autism Index. décimale : PER Périodiques Résumé : Interpreting emotional expressions appropriately poses a challenge for individuals with autism spectrum disorder (ASD). In particular, difficulties with emotional processing in ASD are more pronounced in contexts where emotional expressions are subtle, automatic, and reflexive—that is, implicit. In contrast, explicit emotional processing, which requires the cognitive evaluation of an emotional experience, appears to be relatively intact in individuals with ASD. In the present study, we examined the brain activation and functional connectivity differences underlying explicit and implicit emotional processing in age- and IQ-matched adults with (n?=?17) and without (n?=?15) ASD. Results indicated: (1) significantly reduced levels of brain activation in participants with ASD in medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit emotion processing; (2) significantly weaker functional connectivity in the ASD group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, and fusiform gyrus; (3) No group difference in performance accuracy or reaction time; and (4) Significant positive relationship between empathizing ability and STG activity in ASD but not in typically developing participants. These findings suggest that the neural mechanisms underlying implicit, but not explicit, emotion processing may be altered at multiple levels in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.55-66[article] Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism [Texte imprimé et/ou numérique] / Rajesh K. KANA, Auteur ; Michelle A. PATRIQUIN, Auteur ; Briley S. BLACK, Auteur ; Marie M. CHANNELL, Auteur ; Bruno WICKER, Auteur . - p.55-66.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.55-66
Mots-clés : implicit emotion explicit emotion fMRI functional connectivity autism Index. décimale : PER Périodiques Résumé : Interpreting emotional expressions appropriately poses a challenge for individuals with autism spectrum disorder (ASD). In particular, difficulties with emotional processing in ASD are more pronounced in contexts where emotional expressions are subtle, automatic, and reflexive—that is, implicit. In contrast, explicit emotional processing, which requires the cognitive evaluation of an emotional experience, appears to be relatively intact in individuals with ASD. In the present study, we examined the brain activation and functional connectivity differences underlying explicit and implicit emotional processing in age- and IQ-matched adults with (n?=?17) and without (n?=?15) ASD. Results indicated: (1) significantly reduced levels of brain activation in participants with ASD in medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit emotion processing; (2) significantly weaker functional connectivity in the ASD group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, and fusiform gyrus; (3) No group difference in performance accuracy or reaction time; and (4) Significant positive relationship between empathizing ability and STG activity in ASD but not in typically developing participants. These findings suggest that the neural mechanisms underlying implicit, but not explicit, emotion processing may be altered at multiple levels in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Motor Circuit Anatomy in Children with Autism Spectrum Disorder With or Without Attention Deficit Hyperactivity Disorder / Rajneesh MAHAJAN in Autism Research, 9-1 (January 2016)
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[article]
Titre : Motor Circuit Anatomy in Children with Autism Spectrum Disorder With or Without Attention Deficit Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rajneesh MAHAJAN, Auteur ; Benjamin DIRLIKOV, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : p.67-81 Langues : Anglais (eng) Mots-clés : structural MRI motor circuit autism spectrum disorder attention deficit hyperactivity disorder Index. décimale : PER Périodiques Résumé : This study examined the morphology of frontal-parietal regions relevant to motor functions in children with autism spectrum disorder (ASD) with or without attention deficit hyperactivity disorder (ADHD). We also explored its associations with autism severity and motor skills, and the impact of comorbid ADHD on these associations. Participants included 126 school-age children: 30 had ASD only, 33 had ASD with ADHD, and 63 were typically developing. High resolution 3T MPRAGE images were acquired to examine the cortical morphology (gray matter volume, GMV, surface area, SA, and cortical thickness, CT) in three regions of interest (ROI): precentral gyrus (M1), postcentral gyrus (S1), and inferior parietal cortex (IPC). Children with ASD showed abnormal increases in GMV and SA in all three ROIs: (a) increased GMV in S1 bilaterally and in right M1 was specific to children with ASD without ADHD; (b) all children with ASD (with or without ADHD) showed increases in the left IPC SA. Furthermore, on measures of motor function, impaired praxis was associated with increased GMV in right S1 in the ASD group with ADHD. Children with ASD with ADHD showed a positive relationship between bilateral S1 GMV and manual dexterity, whereas children with ASD without ADHD showed a negative relationship. Our findings suggest that (a) ASD is associated with abnormal morphology of cortical circuits crucial to motor control and learning; (b) anomalous overgrowth of these regions, particularly S1, may contribute to impaired motor skill development, and (c) functional and morphological differences are apparent between children with ASD with or without ADHD. En ligne : http://dx.doi.org/10.1002/aur.1497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.67-81[article] Motor Circuit Anatomy in Children with Autism Spectrum Disorder With or Without Attention Deficit Hyperactivity Disorder [Texte imprimé et/ou numérique] / Rajneesh MAHAJAN, Auteur ; Benjamin DIRLIKOV, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur . - p.67-81.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.67-81
Mots-clés : structural MRI motor circuit autism spectrum disorder attention deficit hyperactivity disorder Index. décimale : PER Périodiques Résumé : This study examined the morphology of frontal-parietal regions relevant to motor functions in children with autism spectrum disorder (ASD) with or without attention deficit hyperactivity disorder (ADHD). We also explored its associations with autism severity and motor skills, and the impact of comorbid ADHD on these associations. Participants included 126 school-age children: 30 had ASD only, 33 had ASD with ADHD, and 63 were typically developing. High resolution 3T MPRAGE images were acquired to examine the cortical morphology (gray matter volume, GMV, surface area, SA, and cortical thickness, CT) in three regions of interest (ROI): precentral gyrus (M1), postcentral gyrus (S1), and inferior parietal cortex (IPC). Children with ASD showed abnormal increases in GMV and SA in all three ROIs: (a) increased GMV in S1 bilaterally and in right M1 was specific to children with ASD without ADHD; (b) all children with ASD (with or without ADHD) showed increases in the left IPC SA. Furthermore, on measures of motor function, impaired praxis was associated with increased GMV in right S1 in the ASD group with ADHD. Children with ASD with ADHD showed a positive relationship between bilateral S1 GMV and manual dexterity, whereas children with ASD without ADHD showed a negative relationship. Our findings suggest that (a) ASD is associated with abnormal morphology of cortical circuits crucial to motor control and learning; (b) anomalous overgrowth of these regions, particularly S1, may contribute to impaired motor skill development, and (c) functional and morphological differences are apparent between children with ASD with or without ADHD. En ligne : http://dx.doi.org/10.1002/aur.1497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Abnormalities in brain systems supporting individuation and enumeration in autism / Kirsten O'HEARN in Autism Research, 9-1 (January 2016)
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[article]
Titre : Abnormalities in brain systems supporting individuation and enumeration in autism Type de document : Texte imprimé et/ou numérique Auteurs : Kirsten O'HEARN, Auteur ; Katerina VELANOVA, Auteur ; Andrew LYNN, Auteur ; Catherine WRIGHT, Auteur ; Michael HALLQUIST, Auteur ; Nancy MINSHEW, Auteur ; Beatriz LUNA, Auteur Article en page(s) : p.82-96 Langues : Anglais (eng) Mots-clés : autism spectrum disorder fMRI parietal number subitizing counting Index. décimale : PER Périodiques Résumé : Previous work indicates that adults with autism display a decreased capacity when rapidly enumerating small sets of elements (i.e., subitizing), compared to typically developing (TD) individuals. This ability is crucial for fundamental visual functions such as object individuation and parallel processing. Thus, the deficit in autism suggests limits in these skills. To examine the neural basis of this limitation, adults with and without high functioning autism rapidly enumerated 1 to 8 randomly located squares during a neuroimaging study. Typically, adults are thought to use parallel visual processes to quantify up to three or four elements, and serial processes to enumerate more (5+) elements. We hypothesized that parietal lobe regions associated with counting would be recruited with smaller sets of elements in adults with autism, compared to TD adults. Consistent with this hypothesis, activation in parietal regions increased with smaller set sizes in adults with autism compared to TD adults. Increased activation for three elements was evident in several regions, including those thought to underlie subitizing. In addition, regions specific to the counting range in TD adults were often equally active for set sizes in the subitizing range in the adults with autism. Finally, significant deactivation was evident in TD adults, presumably reflecting relative suppression of regions specialized for competing processes, but was not apparent in adults with autism. These differences in brain function in adults with autism on a simple enumeration task suggest atypical brain organization and function that is likely to impact most visual tasks, especially those with multiple elements. En ligne : http://dx.doi.org/10.1002/aur.1498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.82-96[article] Abnormalities in brain systems supporting individuation and enumeration in autism [Texte imprimé et/ou numérique] / Kirsten O'HEARN, Auteur ; Katerina VELANOVA, Auteur ; Andrew LYNN, Auteur ; Catherine WRIGHT, Auteur ; Michael HALLQUIST, Auteur ; Nancy MINSHEW, Auteur ; Beatriz LUNA, Auteur . - p.82-96.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.82-96
Mots-clés : autism spectrum disorder fMRI parietal number subitizing counting Index. décimale : PER Périodiques Résumé : Previous work indicates that adults with autism display a decreased capacity when rapidly enumerating small sets of elements (i.e., subitizing), compared to typically developing (TD) individuals. This ability is crucial for fundamental visual functions such as object individuation and parallel processing. Thus, the deficit in autism suggests limits in these skills. To examine the neural basis of this limitation, adults with and without high functioning autism rapidly enumerated 1 to 8 randomly located squares during a neuroimaging study. Typically, adults are thought to use parallel visual processes to quantify up to three or four elements, and serial processes to enumerate more (5+) elements. We hypothesized that parietal lobe regions associated with counting would be recruited with smaller sets of elements in adults with autism, compared to TD adults. Consistent with this hypothesis, activation in parietal regions increased with smaller set sizes in adults with autism compared to TD adults. Increased activation for three elements was evident in several regions, including those thought to underlie subitizing. In addition, regions specific to the counting range in TD adults were often equally active for set sizes in the subitizing range in the adults with autism. Finally, significant deactivation was evident in TD adults, presumably reflecting relative suppression of regions specialized for competing processes, but was not apparent in adults with autism. These differences in brain function in adults with autism on a simple enumeration task suggest atypical brain organization and function that is likely to impact most visual tasks, especially those with multiple elements. En ligne : http://dx.doi.org/10.1002/aur.1498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Relational Memory Processes in Adults with Autism Spectrum Disorder / Melanie RING in Autism Research, 9-1 (January 2016)
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[article]
Titre : Relational Memory Processes in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melanie RING, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur Article en page(s) : p.97-106 Langues : Anglais (eng) Mots-clés : item memory relational memory autism spectrum disorder ageing Index. décimale : PER Périodiques Résumé : Research into memory in Autism Spectrum Disorder (ASD) suggests intact item memory but difficulties in forming relations between items (Bowler, Gaigg, & Lind, 2011). In this study, we tested memory for items as well as for sequential, spatial, and associative relations between items with the same paradigm using abstract shapes in ASD and typically developing (TD) individuals. Participants studied shape triplets on a computer screen and memory was subsequently tested either for the individual items making up the triplets, the screen-locations, the order or the combinations of items presented at study. Contrary to our predictions, performance was significantly lower in the ASD group on all four tasks. The result raises questions about how intact item memory is in ASD, which role task complexity plays, and how item-specific versus relational processing affect task performance. One possibility is that TD individuals relied more on relational processing in the current study and might have therefore had an advantage over ASD individuals. This idea is supported by the result of a preliminary analysis of age-related differences in memory across the midadult lifespan in both groups. Age seems to affect order memory less in ASD compared with TD individuals where it leads to a significant decrease in performance. This might indicate a decrease in relational processing in TD but not ASD individuals with increasing age. More research is needed to answer questions about the change in cognition in ASD individuals across the lifespan. En ligne : http://dx.doi.org/10.1002/aur.1493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.97-106[article] Relational Memory Processes in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Melanie RING, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur . - p.97-106.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.97-106
Mots-clés : item memory relational memory autism spectrum disorder ageing Index. décimale : PER Périodiques Résumé : Research into memory in Autism Spectrum Disorder (ASD) suggests intact item memory but difficulties in forming relations between items (Bowler, Gaigg, & Lind, 2011). In this study, we tested memory for items as well as for sequential, spatial, and associative relations between items with the same paradigm using abstract shapes in ASD and typically developing (TD) individuals. Participants studied shape triplets on a computer screen and memory was subsequently tested either for the individual items making up the triplets, the screen-locations, the order or the combinations of items presented at study. Contrary to our predictions, performance was significantly lower in the ASD group on all four tasks. The result raises questions about how intact item memory is in ASD, which role task complexity plays, and how item-specific versus relational processing affect task performance. One possibility is that TD individuals relied more on relational processing in the current study and might have therefore had an advantage over ASD individuals. This idea is supported by the result of a preliminary analysis of age-related differences in memory across the midadult lifespan in both groups. Age seems to affect order memory less in ASD compared with TD individuals where it leads to a significant decrease in performance. This might indicate a decrease in relational processing in TD but not ASD individuals with increasing age. More research is needed to answer questions about the change in cognition in ASD individuals across the lifespan. En ligne : http://dx.doi.org/10.1002/aur.1493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Audiometric Profiles in Autism Spectrum Disorders: Does Subclinical Hearing Loss Impact Communication? / Carly DEMOPOULOS in Autism Research, 9-1 (January 2016)
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[article]
Titre : Audiometric Profiles in Autism Spectrum Disorders: Does Subclinical Hearing Loss Impact Communication? Type de document : Texte imprimé et/ou numérique Auteurs : Carly DEMOPOULOS, Auteur ; Jeffrey David LEWINE, Auteur Article en page(s) : p.107-120 Langues : Anglais (eng) Mots-clés : autism audiology communication hearing auditory brainstem response Index. décimale : PER Périodiques Résumé : Rates of hearing impairment in individuals with Autism Spectrum Disorders (ASD) are higher than those reported in the general population. Although ASD is not caused by hearing impairment, it may exacerbate symptomatology. Participants with ASD (N?=?60) and typically developing peers (N?=?16) aged 5–18 years underwent a comprehensive audiological screening (pure tone audiometry, uncomfortable loudness level, tympanometry, acoustic reflexes, distortion product otoacoustic emissions, and auditory brainstem response) and assessment of communication abilities (expressive/receptive language, articulation, phonological awareness, and vocal affect recognition). Incidence of abnormal findings on at least one measure of audiological functioning was higher for the ASD group (55%) than controls (14.9%) or the general population estimate (6%). The presence of sound sensitivity was also considerably higher for the ASD group (37%) compared with controls (0%) or general population estimates (8–15%). When participants with ASD were dichotomized into groups with and without evidence of clinical audiological abnormality, no significant differences were identified on measures of communication; however, results of correlational analyses indicated that variability in hearing thresholds at middle range frequencies (2000 Hz) was significantly related to performance on all measures of speech articulation and language after correction for multiple comparisons (r?=??0.48 to r?=??0.53, P? 0.0045). These findings suggest that dichotomized classification of clinical audiology may not be sufficient to understand the role of subclinical hearing loss in ASD symptomatology and that treatment studies for mild/subclinical hearing loss in this population may be worthwhile. En ligne : http://dx.doi.org/10.1002/aur.1495 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.107-120[article] Audiometric Profiles in Autism Spectrum Disorders: Does Subclinical Hearing Loss Impact Communication? [Texte imprimé et/ou numérique] / Carly DEMOPOULOS, Auteur ; Jeffrey David LEWINE, Auteur . - p.107-120.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.107-120
Mots-clés : autism audiology communication hearing auditory brainstem response Index. décimale : PER Périodiques Résumé : Rates of hearing impairment in individuals with Autism Spectrum Disorders (ASD) are higher than those reported in the general population. Although ASD is not caused by hearing impairment, it may exacerbate symptomatology. Participants with ASD (N?=?60) and typically developing peers (N?=?16) aged 5–18 years underwent a comprehensive audiological screening (pure tone audiometry, uncomfortable loudness level, tympanometry, acoustic reflexes, distortion product otoacoustic emissions, and auditory brainstem response) and assessment of communication abilities (expressive/receptive language, articulation, phonological awareness, and vocal affect recognition). Incidence of abnormal findings on at least one measure of audiological functioning was higher for the ASD group (55%) than controls (14.9%) or the general population estimate (6%). The presence of sound sensitivity was also considerably higher for the ASD group (37%) compared with controls (0%) or general population estimates (8–15%). When participants with ASD were dichotomized into groups with and without evidence of clinical audiological abnormality, no significant differences were identified on measures of communication; however, results of correlational analyses indicated that variability in hearing thresholds at middle range frequencies (2000 Hz) was significantly related to performance on all measures of speech articulation and language after correction for multiple comparisons (r?=??0.48 to r?=??0.53, P? 0.0045). These findings suggest that dichotomized classification of clinical audiology may not be sufficient to understand the role of subclinical hearing loss in ASD symptomatology and that treatment studies for mild/subclinical hearing loss in this population may be worthwhile. En ligne : http://dx.doi.org/10.1002/aur.1495 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Cognitive Mechanisms underlying visual perspective taking in typical and ASC children / Amy PEARSON in Autism Research, 9-1 (January 2016)
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[article]
Titre : Cognitive Mechanisms underlying visual perspective taking in typical and ASC children Type de document : Texte imprimé et/ou numérique Auteurs : Amy PEARSON, Auteur ; Lauren MARSH, Auteur ; Danielle ROPAR, Auteur ; Antonia HAMILTON, Auteur Article en page(s) : p.121-130 Langues : Anglais (eng) Mots-clés : autism spectrum conditions visual perspective taking mental rotation embodied cognitive mechanisms Index. décimale : PER Périodiques Résumé : Previous research has suggested that people with Autism Spectrum Conditions (ASC) may have difficulty with visual perspective taking (VPT) but it is not clear how this relates to different strategies that can be used in perspective taking tasks. The current study examined VPT in 30 children with autism and 30 verbal mental age matched typical children, in comparison to mental rotation (MR) abilities and body representation abilities. Using a similar paradigm to Hamilton, Brindley, and Frith [2009] all children completed three tasks: a VPT task in which children decided what a toy on a table would look like from a different points of view; a MR task in which the child decided what a toy would look like after it had been rotated; and a body posture matching task, in which children matched pictures of a body shown from different viewpoints. Results showed that children with ASC performed better than the typically developing children on the MR task, and at a similar level on the VPT task and body matching task. Importantly, in the typical children VPT performance was predicted by performance on the body matching task, whereas in the ASC children VPT performance was predicted by MR ability. These findings suggest that differences in VPT in ASC may be explained by the use of a spatial rotation strategy rather than the embodied egocentric transformation strategy used by typical children. En ligne : http://dx.doi.org/10.1002/aur.1501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.121-130[article] Cognitive Mechanisms underlying visual perspective taking in typical and ASC children [Texte imprimé et/ou numérique] / Amy PEARSON, Auteur ; Lauren MARSH, Auteur ; Danielle ROPAR, Auteur ; Antonia HAMILTON, Auteur . - p.121-130.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.121-130
Mots-clés : autism spectrum conditions visual perspective taking mental rotation embodied cognitive mechanisms Index. décimale : PER Périodiques Résumé : Previous research has suggested that people with Autism Spectrum Conditions (ASC) may have difficulty with visual perspective taking (VPT) but it is not clear how this relates to different strategies that can be used in perspective taking tasks. The current study examined VPT in 30 children with autism and 30 verbal mental age matched typical children, in comparison to mental rotation (MR) abilities and body representation abilities. Using a similar paradigm to Hamilton, Brindley, and Frith [2009] all children completed three tasks: a VPT task in which children decided what a toy on a table would look like from a different points of view; a MR task in which the child decided what a toy would look like after it had been rotated; and a body posture matching task, in which children matched pictures of a body shown from different viewpoints. Results showed that children with ASC performed better than the typically developing children on the MR task, and at a similar level on the VPT task and body matching task. Importantly, in the typical children VPT performance was predicted by performance on the body matching task, whereas in the ASC children VPT performance was predicted by MR ability. These findings suggest that differences in VPT in ASC may be explained by the use of a spatial rotation strategy rather than the embodied egocentric transformation strategy used by typical children. En ligne : http://dx.doi.org/10.1002/aur.1501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 The differential effects of Autism and Down's syndrome on sexual behavior / Maria Cristina GINEVRA in Autism Research, 9-1 (January 2016)
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[article]
Titre : The differential effects of Autism and Down's syndrome on sexual behavior Type de document : Texte imprimé et/ou numérique Auteurs : Maria Cristina GINEVRA, Auteur ; Laura NOTA, Auteur ; Mark A. STOKES, Auteur Article en page(s) : p.131-140 Langues : Anglais (eng) Mots-clés : sexuality adolescents autism Down's syndrome Index. décimale : PER Périodiques Résumé : Although sexuality plays a major role in the socialization of people, few studies have examined the sexual behaviors of individuals with developmental disabilities. Because of this, we decided to investigate sexuality in adolescents with autism spectrum disorder (ASD) and Down's syndrome (Ds) and to compare them with typically developing adolescents, by surveying their parents. Specifically, it was hypothesized that young people with ASD would display lower levels over five domains: social behavior, privacy, sex education, sexual behavior, and parental concerns, than peers with Ds and typically developing young people. In addition, we sought to verify developmental trends in five domains with age for each group. Overall, 269 parents participated; 94 parents of typically developing adolescents, 93 parents of adolescents diagnosed with Ds, and 82 parents of adolescents diagnosed with ASD. Participants were surveyed with a Sexual Behavior Scale developed by Stokes and Kaur [] that assesses parents' reports of their child's: social behavior, privacy awareness, sex education, sexual behavior and parental concerns about the child's behaviors. It was found that three groups were significantly different on all five domains, adolescents with ASD reportedly displaying lower levels than other groups. Moreover, there was a significant improvement in knowledge of privacy and parental concerns with age for adolescents with ASD and a decline in sex education for adolescents with Ds. The results obtained emphasize the need to train adolescents with developmental disability, and especially for adolescents with ASD through sex education programs. En ligne : http://dx.doi.org/10.1002/aur.1504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.131-140[article] The differential effects of Autism and Down's syndrome on sexual behavior [Texte imprimé et/ou numérique] / Maria Cristina GINEVRA, Auteur ; Laura NOTA, Auteur ; Mark A. STOKES, Auteur . - p.131-140.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.131-140
Mots-clés : sexuality adolescents autism Down's syndrome Index. décimale : PER Périodiques Résumé : Although sexuality plays a major role in the socialization of people, few studies have examined the sexual behaviors of individuals with developmental disabilities. Because of this, we decided to investigate sexuality in adolescents with autism spectrum disorder (ASD) and Down's syndrome (Ds) and to compare them with typically developing adolescents, by surveying their parents. Specifically, it was hypothesized that young people with ASD would display lower levels over five domains: social behavior, privacy, sex education, sexual behavior, and parental concerns, than peers with Ds and typically developing young people. In addition, we sought to verify developmental trends in five domains with age for each group. Overall, 269 parents participated; 94 parents of typically developing adolescents, 93 parents of adolescents diagnosed with Ds, and 82 parents of adolescents diagnosed with ASD. Participants were surveyed with a Sexual Behavior Scale developed by Stokes and Kaur [] that assesses parents' reports of their child's: social behavior, privacy awareness, sex education, sexual behavior and parental concerns about the child's behaviors. It was found that three groups were significantly different on all five domains, adolescents with ASD reportedly displaying lower levels than other groups. Moreover, there was a significant improvement in knowledge of privacy and parental concerns with age for adolescents with ASD and a decline in sex education for adolescents with Ds. The results obtained emphasize the need to train adolescents with developmental disability, and especially for adolescents with ASD through sex education programs. En ligne : http://dx.doi.org/10.1002/aur.1504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 The Impact of Reading Intervention on Brain Responses Underlying Language in Children With Autism / Donna L. MURDAUGH in Autism Research, 9-1 (January 2016)
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[article]
Titre : The Impact of Reading Intervention on Brain Responses Underlying Language in Children With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Donna L. MURDAUGH, Auteur ; Hrishikesh D. DESHPANDE, Auteur ; Rajesh K. KANA, Auteur Article en page(s) : p.141-154 Langues : Anglais (eng) Mots-clés : autism intervention high imagery low-imagery language comprehension functional MRI functional connectivity reading comprehension Index. décimale : PER Périodiques Résumé : Deficits in language comprehension have been widely reported in children with autism spectrum disorders (ASD), with behavioral and neuroimaging studies finding increased reliance on visuospatial processing to aid in language comprehension. However, no study to date, has taken advantage of this strength in visuospatial processing to improve language comprehension difficulties in ASD. This study used a translational neuroimaging approach to test the role of a visual imagery-based reading intervention in improving the brain circuitry underlying language processing in children with ASD. Functional magnetic resonance imaging (MRI), in a longitudinal study design, was used to investigate intervention-related change in sentence comprehension, brain activation, and functional connectivity in three groups of participants (age 8–13 years): an experimental group of ASD children (ASD-EXP), a wait-list control group of ASD children (ASD-WLC), and a group of typically developing control children. After intervention, the ASD-EXP group showed significant increase in activity in visual and language areas and right-hemisphere language area homologues, putamen, and thalamus, suggestive of compensatory routes to increase proficiency in reading comprehension. Additionally, ASD children who had the most improvement in reading comprehension after intervention showed greater functional connectivity between left-hemisphere language areas, the middle temporal gyrus and inferior frontal gyrus while reading high imagery sentences. Thus, the findings of this study, which support the principles of dual coding theory [Paivio 2007], suggest the potential of a strength-based reading intervention in changing brain responses and facilitating better reading comprehension in ASD children. En ligne : http://dx.doi.org/10.1002/aur.1503 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.141-154[article] The Impact of Reading Intervention on Brain Responses Underlying Language in Children With Autism [Texte imprimé et/ou numérique] / Donna L. MURDAUGH, Auteur ; Hrishikesh D. DESHPANDE, Auteur ; Rajesh K. KANA, Auteur . - p.141-154.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.141-154
Mots-clés : autism intervention high imagery low-imagery language comprehension functional MRI functional connectivity reading comprehension Index. décimale : PER Périodiques Résumé : Deficits in language comprehension have been widely reported in children with autism spectrum disorders (ASD), with behavioral and neuroimaging studies finding increased reliance on visuospatial processing to aid in language comprehension. However, no study to date, has taken advantage of this strength in visuospatial processing to improve language comprehension difficulties in ASD. This study used a translational neuroimaging approach to test the role of a visual imagery-based reading intervention in improving the brain circuitry underlying language processing in children with ASD. Functional magnetic resonance imaging (MRI), in a longitudinal study design, was used to investigate intervention-related change in sentence comprehension, brain activation, and functional connectivity in three groups of participants (age 8–13 years): an experimental group of ASD children (ASD-EXP), a wait-list control group of ASD children (ASD-WLC), and a group of typically developing control children. After intervention, the ASD-EXP group showed significant increase in activity in visual and language areas and right-hemisphere language area homologues, putamen, and thalamus, suggestive of compensatory routes to increase proficiency in reading comprehension. Additionally, ASD children who had the most improvement in reading comprehension after intervention showed greater functional connectivity between left-hemisphere language areas, the middle temporal gyrus and inferior frontal gyrus while reading high imagery sentences. Thus, the findings of this study, which support the principles of dual coding theory [Paivio 2007], suggest the potential of a strength-based reading intervention in changing brain responses and facilitating better reading comprehension in ASD children. En ligne : http://dx.doi.org/10.1002/aur.1503 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
[article]
Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.155-159 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.155-159[article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.155-159.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.155-159
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
[article]
Titre : International Society For Autism Research News Type de document : Texte imprimé et/ou numérique Article en page(s) : p.160-160 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1611 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.160-160[article] International Society For Autism Research News [Texte imprimé et/ou numérique] . - p.160-160.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.160-160
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1611 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282