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Auteur Luis A. ROHDE |
Documents disponibles écrits par cet auteur (4)
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Annual Research Review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents / Guilherme V. POLANCZYK in Journal of Child Psychology and Psychiatry, 56-3 (March 2015)
[article]
Titre : Annual Research Review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Guilherme V. POLANCZYK, Auteur ; Giovanni A. SALUM, Auteur ; Luisa S. SUGAYA, Auteur ; Arthur CAYE, Auteur ; Luis A. ROHDE, Auteur Article en page(s) : p.345-365 Langues : Anglais (eng) Mots-clés : Mental disorders anxiety disorders depressive disorders ADHD disruptive behavior disorders children prevalence epidemiology meta-analysis cross-cultural Index. décimale : PER Périodiques Résumé : Background The literature on the prevalence of mental disorders affecting children and adolescents has expanded significantly over the last three decades around the world. Despite the field having matured significantly, there has been no meta-analysis to calculate a worldwide-pooled prevalence and to empirically assess the sources of heterogeneity of estimates. Methods We conducted a systematic review of the literature searching in PubMed, PsycINFO, and EMBASE for prevalence studies of mental disorders investigating probabilistic community samples of children and adolescents with standardized assessments methods that derive diagnoses according to the DSM or ICD. Meta-analytical techniques were used to estimate the prevalence rates of any mental disorder and individual diagnostic groups. A meta-regression analysis was performed to estimate the effect of population and sample characteristics, study methods, assessment procedures, and case definition in determining the heterogeneity of estimates. Results We included 41 studies conducted in 27 countries from every world region. The worldwide-pooled prevalence of mental disorders was 13.4% (CI 95% 11.3–15.9). The worldwide prevalence of any anxiety disorder was 6.5% (CI 95% 4.7–9.1), any depressive disorder was 2.6% (CI 95% 1.7–3.9), attention-deficit hyperactivity disorder was 3.4% (CI 95% 2.6–4.5), and any disruptive disorder was 5.7% (CI 95% 4.0–8.1). Significant heterogeneity was detected for all pooled estimates. The multivariate metaregression analyses indicated that sample representativeness, sample frame, and diagnostic interview were significant moderators of prevalence estimates. Estimates did not vary as a function of geographic location of studies and year of data collection. The multivariate model explained 88.89% of prevalence heterogeneity, but residual heterogeneity was still significant. Additional meta-analysis detected significant pooled difference in prevalence rates according to requirement of funcional impairment for the diagnosis of mental disorders. Conclusions Our findings suggest that mental disorders affect a significant number of children and adolescents worldwide. The pooled prevalence estimates and the identification of sources of heterogeneity have important implications to service, training, and research planning around the world. En ligne : http://dx.doi.org/10.1111/jcpp.12381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.345-365[article] Annual Research Review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents [Texte imprimé et/ou numérique] / Guilherme V. POLANCZYK, Auteur ; Giovanni A. SALUM, Auteur ; Luisa S. SUGAYA, Auteur ; Arthur CAYE, Auteur ; Luis A. ROHDE, Auteur . - p.345-365.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.345-365
Mots-clés : Mental disorders anxiety disorders depressive disorders ADHD disruptive behavior disorders children prevalence epidemiology meta-analysis cross-cultural Index. décimale : PER Périodiques Résumé : Background The literature on the prevalence of mental disorders affecting children and adolescents has expanded significantly over the last three decades around the world. Despite the field having matured significantly, there has been no meta-analysis to calculate a worldwide-pooled prevalence and to empirically assess the sources of heterogeneity of estimates. Methods We conducted a systematic review of the literature searching in PubMed, PsycINFO, and EMBASE for prevalence studies of mental disorders investigating probabilistic community samples of children and adolescents with standardized assessments methods that derive diagnoses according to the DSM or ICD. Meta-analytical techniques were used to estimate the prevalence rates of any mental disorder and individual diagnostic groups. A meta-regression analysis was performed to estimate the effect of population and sample characteristics, study methods, assessment procedures, and case definition in determining the heterogeneity of estimates. Results We included 41 studies conducted in 27 countries from every world region. The worldwide-pooled prevalence of mental disorders was 13.4% (CI 95% 11.3–15.9). The worldwide prevalence of any anxiety disorder was 6.5% (CI 95% 4.7–9.1), any depressive disorder was 2.6% (CI 95% 1.7–3.9), attention-deficit hyperactivity disorder was 3.4% (CI 95% 2.6–4.5), and any disruptive disorder was 5.7% (CI 95% 4.0–8.1). Significant heterogeneity was detected for all pooled estimates. The multivariate metaregression analyses indicated that sample representativeness, sample frame, and diagnostic interview were significant moderators of prevalence estimates. Estimates did not vary as a function of geographic location of studies and year of data collection. The multivariate model explained 88.89% of prevalence heterogeneity, but residual heterogeneity was still significant. Additional meta-analysis detected significant pooled difference in prevalence rates according to requirement of funcional impairment for the diagnosis of mental disorders. Conclusions Our findings suggest that mental disorders affect a significant number of children and adolescents worldwide. The pooled prevalence estimates and the identification of sources of heterogeneity have important implications to service, training, and research planning around the world. En ligne : http://dx.doi.org/10.1111/jcpp.12381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Association between irritability and bias in attention orienting to threat in children and adolescents / Giovanni A. SALUM in Journal of Child Psychology and Psychiatry, 58-5 (May 2017)
[article]
Titre : Association between irritability and bias in attention orienting to threat in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Giovanni A. SALUM, Auteur ; Karin MOGG, Auteur ; Brendan P. BRADLEY, Auteur ; Argyris STRINGARIS, Auteur ; Ary GADELHA, Auteur ; Pedro M. PAN, Auteur ; Luis A. ROHDE, Auteur ; Guilherme V. POLANCZYK, Auteur ; Gisele G. MANFRO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur Article en page(s) : p.595-602 Langues : Anglais (eng) Mots-clés : Irritability anger attention bias cognition emotion Index. décimale : PER Périodiques Résumé : Background Irritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample. Methods We studied 1,872 children (ages 6–14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits. Results Irritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms. Conclusions Irritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications. En ligne : http://dx.doi.org/10.1111/jcpp.12659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306
in Journal of Child Psychology and Psychiatry > 58-5 (May 2017) . - p.595-602[article] Association between irritability and bias in attention orienting to threat in children and adolescents [Texte imprimé et/ou numérique] / Giovanni A. SALUM, Auteur ; Karin MOGG, Auteur ; Brendan P. BRADLEY, Auteur ; Argyris STRINGARIS, Auteur ; Ary GADELHA, Auteur ; Pedro M. PAN, Auteur ; Luis A. ROHDE, Auteur ; Guilherme V. POLANCZYK, Auteur ; Gisele G. MANFRO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur . - p.595-602.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-5 (May 2017) . - p.595-602
Mots-clés : Irritability anger attention bias cognition emotion Index. décimale : PER Périodiques Résumé : Background Irritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample. Methods We studied 1,872 children (ages 6–14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits. Results Irritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms. Conclusions Irritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications. En ligne : http://dx.doi.org/10.1111/jcpp.12659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306 Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways / Luiza K. AXELRUD in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)
[article]
Titre : Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways Type de document : Texte imprimé et/ou numérique Auteurs : Luiza K. AXELRUD, Auteur ; Mauricio S. HOFFMANN, Auteur ; Daniel E. VOSBERG, Auteur ; Marcos SANTORO, Auteur ; Pedro M. PAN, Auteur ; Ary GADELHA, Auteur ; Sintia I. BELANGERO, Auteur ; Euripedes C. MIGUEL, Auteur ; Jean SHIN, Auteur ; Anita THAPAR, Auteur ; Jordan W. SMOLLER, Auteur ; Zdenka PAUSOVA, Auteur ; Luis A. ROHDE, Auteur ; Matthew C. KELLER, Auteur ; Tomas PAUS, Auteur ; Giovanni A. SALUM, Auteur Article en page(s) : p.408-416 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. Methods Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores (PGS) for cognition, educational attainment, attention-deficit hyperactivity disorder (ADHD), and schizophrenia for the trios. Phenotypes studied included educational and cognitive measures, ADHD and psychotic symptoms. We used a stepwise approach and multiple mediation models to analyze the effect of parental PGS on offspring traits via offspring PGS and parental phenotype. Significant results were replicated in a sample of 1,029 adolescents, 363 mothers, and 307 fathers. Results Maternal and paternal PGS for cognition influenced offspring general intelligence and executive function via offspring PGS (genetic pathway) and parental education (phenotypic pathway). Similar results were found for parental PGS for educational attainment and offspring reading and writing skills. These pathways fully explained associations between parental PGS and offspring phenotypes, without residual direct association. Associations with maternal, but not paternal, PGS were replicated. No associations were found between parental PGS for psychopathology and offspring specific symptoms. Conclusions Our findings indicate that parental genetics influences offspring cognition and educational attainment by genetic and phenotypic pathways, suggesting the expression of parental phenotypes partially explain the association between parental genetic risk and offspring outcomes. Multiple mediations might represent an effective approach to disentangle distinct pathways for intergenerational transmission of behavioral traits. En ligne : https://doi.org/10.1111/jcpp.13708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493
in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.408-416[article] Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways [Texte imprimé et/ou numérique] / Luiza K. AXELRUD, Auteur ; Mauricio S. HOFFMANN, Auteur ; Daniel E. VOSBERG, Auteur ; Marcos SANTORO, Auteur ; Pedro M. PAN, Auteur ; Ary GADELHA, Auteur ; Sintia I. BELANGERO, Auteur ; Euripedes C. MIGUEL, Auteur ; Jean SHIN, Auteur ; Anita THAPAR, Auteur ; Jordan W. SMOLLER, Auteur ; Zdenka PAUSOVA, Auteur ; Luis A. ROHDE, Auteur ; Matthew C. KELLER, Auteur ; Tomas PAUS, Auteur ; Giovanni A. SALUM, Auteur . - p.408-416.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.408-416
Index. décimale : PER Périodiques Résumé : Background Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. Methods Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores (PGS) for cognition, educational attainment, attention-deficit hyperactivity disorder (ADHD), and schizophrenia for the trios. Phenotypes studied included educational and cognitive measures, ADHD and psychotic symptoms. We used a stepwise approach and multiple mediation models to analyze the effect of parental PGS on offspring traits via offspring PGS and parental phenotype. Significant results were replicated in a sample of 1,029 adolescents, 363 mothers, and 307 fathers. Results Maternal and paternal PGS for cognition influenced offspring general intelligence and executive function via offspring PGS (genetic pathway) and parental education (phenotypic pathway). Similar results were found for parental PGS for educational attainment and offspring reading and writing skills. These pathways fully explained associations between parental PGS and offspring phenotypes, without residual direct association. Associations with maternal, but not paternal, PGS were replicated. No associations were found between parental PGS for psychopathology and offspring specific symptoms. Conclusions Our findings indicate that parental genetics influences offspring cognition and educational attainment by genetic and phenotypic pathways, suggesting the expression of parental phenotypes partially explain the association between parental genetic risk and offspring outcomes. Multiple mediations might represent an effective approach to disentangle distinct pathways for intergenerational transmission of behavioral traits. En ligne : https://doi.org/10.1111/jcpp.13708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil / Leehyun YOON in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)
[article]
Titre : Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil Type de document : Texte imprimé et/ou numérique Auteurs : Leehyun YOON, Auteur ; Fernanda ROHRSETZER, Auteur ; Lucas BATTEL, Auteur ; Mauricio ANÉS, Auteur ; Pedro H. MANFRO, Auteur ; Luis A. ROHDE, Auteur ; Anna VIDUANI, Auteur ; Zuzanna ZAJKOWSKA, Auteur ; Valeria MONDELLI, Auteur ; Christian KIELING, Auteur ; Johnna R. SWARTZ, Auteur Article en page(s) : p.579-590 Langues : Anglais (eng) Mots-clés : Adolescent Brain/diagnostic imaging Brain Mapping/methods Brazil/epidemiology Depression/epidemiology Humans Magnetic Resonance Imaging/methods Reward Risk Factors Depression adolescence functional MRI (fMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. METHODS: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threat-related face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. RESULTS: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The whole-brain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. CONCLUSIONS: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression. En ligne : http://dx.doi.org/10.1111/jcpp.13496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.579-590[article] Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil [Texte imprimé et/ou numérique] / Leehyun YOON, Auteur ; Fernanda ROHRSETZER, Auteur ; Lucas BATTEL, Auteur ; Mauricio ANÉS, Auteur ; Pedro H. MANFRO, Auteur ; Luis A. ROHDE, Auteur ; Anna VIDUANI, Auteur ; Zuzanna ZAJKOWSKA, Auteur ; Valeria MONDELLI, Auteur ; Christian KIELING, Auteur ; Johnna R. SWARTZ, Auteur . - p.579-590.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.579-590
Mots-clés : Adolescent Brain/diagnostic imaging Brain Mapping/methods Brazil/epidemiology Depression/epidemiology Humans Magnetic Resonance Imaging/methods Reward Risk Factors Depression adolescence functional MRI (fMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. METHODS: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threat-related face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. RESULTS: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The whole-brain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. CONCLUSIONS: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression. En ligne : http://dx.doi.org/10.1111/jcpp.13496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476