A co-twin-control study of altered sensory processing in autism / Janina NEUFELD in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1422-1432 Titre : A co-twin-control study of altered sensory processing in autism Type de document : Texte imprimé et/ou numérique Auteurs : Janina NEUFELD, Auteur ; Mark J. TAYLOR, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; Johan ISAKSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.1422-1432 Langues : Anglais (eng) Mots-clés : Anxiety Disorders  Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Autistic Disorder  Humans  Perception  autism spectrum disorders  behavioral genetics  environmental factors  sensory processing  sensory profile  twin design  potential conflicts of interest with respect to the research, authorship, and/or  publication of this article: S. B. discloses that he has in the last 3 years  acted as an author, consultant or lecturer for Medice, Roche. Hogrefe,  Kohlhammer, and UTB. Index. décimale : PER Périodiques Résumé : Individuals diagnosed with autism often describe that they process sensory information differently from others, and many experience sensory issues as problematic. For instance, an increased sensitivity to smells or sounds can make participating in social settings challenging. While sensory issues are now part of the diagnostic criteria for autism, they also co-occur with other psychiatric diagnoses such as attention deficit hyperactivity disorder and anxiety disorders. It is unclear to what extent the relationship between autism and alterations in sensory processing are due to genetics or environment. In addition, more research is needed on how autism, as compared to other diagnoses, is associated with sensory issues. Using a twin study, we found that genetic factors influenced self-reported reactivity to sensory stimuli in autism while environmental factors influenced other sensory issues (e.g. difficulties in detecting or differentiating sensory input). Hence, sensory hyper-reactivity might be an early onset core feature of autism, while other domains of alterations in sensory processing might develop later, influenced by the environment. Moreover, autism was more strongly associated with sensory issues related to increased sensitivity/reactivity as compared to other psychiatric diagnoses. However, attention deficit hyperactivity disorder was more strongly related to deficits in detecting/differentiating sensory stimuli and with an increased drive to seek sensory input. Our results indicate that sensory issues are not specific to autism, but that some aspects of altered sensory processing are more relevant for autism than for other diagnoses. En ligne : http://dx.doi.org/10.1177/1362361321991255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] A co-twin-control study of altered sensory processing in autism [Texte imprimé et/ou numérique] / Janina NEUFELD, Auteur ; Mark J. TAYLOR, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; Johan ISAKSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur . - p.1422-1432. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1422-1432 Mots-clés : Anxiety Disorders  Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Autistic Disorder  Humans  Perception  autism spectrum disorders  behavioral genetics  environmental factors  sensory processing  sensory profile  twin design  potential conflicts of interest with respect to the research, authorship, and/or  publication of this article: S. B. discloses that he has in the last 3 years  acted as an author, consultant or lecturer for Medice, Roche. Hogrefe,  Kohlhammer, and UTB. Index. décimale : PER Périodiques Résumé : Individuals diagnosed with autism often describe that they process sensory information differently from others, and many experience sensory issues as problematic. For instance, an increased sensitivity to smells or sounds can make participating in social settings challenging. While sensory issues are now part of the diagnostic criteria for autism, they also co-occur with other psychiatric diagnoses such as attention deficit hyperactivity disorder and anxiety disorders. It is unclear to what extent the relationship between autism and alterations in sensory processing are due to genetics or environment. In addition, more research is needed on how autism, as compared to other diagnoses, is associated with sensory issues. Using a twin study, we found that genetic factors influenced self-reported reactivity to sensory stimuli in autism while environmental factors influenced other sensory issues (e.g. difficulties in detecting or differentiating sensory input). Hence, sensory hyper-reactivity might be an early onset core feature of autism, while other domains of alterations in sensory processing might develop later, influenced by the environment. Moreover, autism was more strongly associated with sensory issues related to increased sensitivity/reactivity as compared to other psychiatric diagnoses. However, attention deficit hyperactivity disorder was more strongly related to deficits in detecting/differentiating sensory stimuli and with an increased drive to seek sensory input. Our results indicate that sensory issues are not specific to autism, but that some aspects of altered sensory processing are more relevant for autism than for other diagnoses. En ligne : http://dx.doi.org/10.1177/1362361321991255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

A co-twin-control study of altered sensory processing in autism / Janina NEUFELD in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1422-1432 Titre : A co-twin-control study of altered sensory processing in autism Type de document : Texte imprimé et/ou numérique Auteurs : Janina NEUFELD, Auteur ; Mark J. TAYLOR, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; Johan ISAKSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.1422-1432 Langues : Anglais (eng) Mots-clés : Anxiety Disorders  Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Autistic Disorder  Humans  Perception  autism spectrum disorders  behavioral genetics  environmental factors  sensory processing  sensory profile  twin design  potential conflicts of interest with respect to the research, authorship, and/or  publication of this article: S. B. discloses that he has in the last 3 years  acted as an author, consultant or lecturer for Medice, Roche. Hogrefe,  Kohlhammer, and UTB. Index. décimale : PER Périodiques Résumé : Individuals diagnosed with autism often describe that they process sensory information differently from others, and many experience sensory issues as problematic. For instance, an increased sensitivity to smells or sounds can make participating in social settings challenging. While sensory issues are now part of the diagnostic criteria for autism, they also co-occur with other psychiatric diagnoses such as attention deficit hyperactivity disorder and anxiety disorders. It is unclear to what extent the relationship between autism and alterations in sensory processing are due to genetics or environment. In addition, more research is needed on how autism, as compared to other diagnoses, is associated with sensory issues. Using a twin study, we found that genetic factors influenced self-reported reactivity to sensory stimuli in autism while environmental factors influenced other sensory issues (e.g. difficulties in detecting or differentiating sensory input). Hence, sensory hyper-reactivity might be an early onset core feature of autism, while other domains of alterations in sensory processing might develop later, influenced by the environment. Moreover, autism was more strongly associated with sensory issues related to increased sensitivity/reactivity as compared to other psychiatric diagnoses. However, attention deficit hyperactivity disorder was more strongly related to deficits in detecting/differentiating sensory stimuli and with an increased drive to seek sensory input. Our results indicate that sensory issues are not specific to autism, but that some aspects of altered sensory processing are more relevant for autism than for other diagnoses. En ligne : http://dx.doi.org/10.1177/1362361321991255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] A co-twin-control study of altered sensory processing in autism [Texte imprimé et/ou numérique] / Janina NEUFELD, Auteur ; Mark J. TAYLOR, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; Johan ISAKSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur . - p.1422-1432. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1422-1432 Mots-clés : Anxiety Disorders  Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Autistic Disorder  Humans  Perception  autism spectrum disorders  behavioral genetics  environmental factors  sensory processing  sensory profile  twin design  potential conflicts of interest with respect to the research, authorship, and/or  publication of this article: S. B. discloses that he has in the last 3 years  acted as an author, consultant or lecturer for Medice, Roche. Hogrefe,  Kohlhammer, and UTB. Index. décimale : PER Périodiques Résumé : Individuals diagnosed with autism often describe that they process sensory information differently from others, and many experience sensory issues as problematic. For instance, an increased sensitivity to smells or sounds can make participating in social settings challenging. While sensory issues are now part of the diagnostic criteria for autism, they also co-occur with other psychiatric diagnoses such as attention deficit hyperactivity disorder and anxiety disorders. It is unclear to what extent the relationship between autism and alterations in sensory processing are due to genetics or environment. In addition, more research is needed on how autism, as compared to other diagnoses, is associated with sensory issues. Using a twin study, we found that genetic factors influenced self-reported reactivity to sensory stimuli in autism while environmental factors influenced other sensory issues (e.g. difficulties in detecting or differentiating sensory input). Hence, sensory hyper-reactivity might be an early onset core feature of autism, while other domains of alterations in sensory processing might develop later, influenced by the environment. Moreover, autism was more strongly associated with sensory issues related to increased sensitivity/reactivity as compared to other psychiatric diagnoses. However, attention deficit hyperactivity disorder was more strongly related to deficits in detecting/differentiating sensory stimuli and with an increased drive to seek sensory input. Our results indicate that sensory issues are not specific to autism, but that some aspects of altered sensory processing are more relevant for autism than for other diagnoses. En ligne : http://dx.doi.org/10.1177/1362361321991255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Eating Problems in Autistic Females and Males: A Co-twin Control Study / K. LUNDIN REMNÉLIUS in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168 Titre : Eating Problems in Autistic Females and Males: A Co-twin Control Study Type de document : Texte imprimé et/ou numérique Auteurs : K. LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3153-3168 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Diseases in Twins/genetics  Female  Humans  Male  Twins, Dizygotic  Twins, Monozygotic  Autism  Co-twin control design  Eating  Gender differences  lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic  tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that  are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Eating Problems in Autistic Females and Males: A Co-twin Control Study [Texte imprimé et/ou numérique] / K. LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur . - p.3153-3168. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Diseases in Twins/genetics  Female  Humans  Male  Twins, Dizygotic  Twins, Monozygotic  Autism  Co-twin control design  Eating  Gender differences  lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic  tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that  are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study / J. ISAKSSON in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 8p. Titre : Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study Type de document : Texte imprimé et/ou numérique Auteurs : J. ISAKSSON, Auteur ; V. RUCHKIN, Auteur ; N. AHO, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; P. B. MARSCHIK, Auteur ; Sven BÖLTE, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : Adhd  Autism  Early adversities  Iq  Non-shared environment  Risk factors  Twins Index. décimale : PER Périodiques Résumé : BACKGROUND: A significant proportion of variation in likelihood of neurodevelopmental conditions (NDCs) has been attributed to nonshared environmental (NSE) factors, although it remains unclear which NSE factors pose specific risks for certain NDCs. METHODS: A monozygotic co-twin design was applied in a sample of 224 twins (mean age?=?17.70 years, SD?=?6.28) controlling for confounders such as genes and shared environment. Generalized estimating equation models were fitted, using perinatal and postnatal indications of NSEs as exposure, operationalized both as separate risk factors and as cumulative risk loads. Categorical and dimensional operationalizations of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), intellectual disability and other NDCs were used as outcomes. RESULTS: Birth weight discordance was associated with dimensional autism and ADHD for the smaller twin, and medication during infancy was associated with dimensional autism. Among postnatal factors scarlet fever during early childhood was associated with lower IQ. Especially autism was associated with a greater cumulative perinatal or postnatal risk load. LIMITATIONS: When exploring the associations between each condition and specific NSEs the risk of being statistically underpowered increases. Hence, we limit the reported findings on specific indicators of NSEs to trait levels and present descriptive data for categorical NDCs. CONCLUSIONS: The findings support previous research by indicating an association between exposure to perinatal and postnatal risks and subsequent NDCs within twin pairs and suggest that autism may be especially linked to accumulative early environmental risks. The findings are potentially important for developmental outcomes prognoses and may inform targeted prevention and early interventions. En ligne : http://dx.doi.org/10.1186/s13229-022-00487-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study [Texte imprimé et/ou numérique] / J. ISAKSSON, Auteur ; V. RUCHKIN, Auteur ; N. AHO, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; P. B. MARSCHIK, Auteur ; Sven BÖLTE, Auteur . - 8p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 8p. Mots-clés : Adhd  Autism  Early adversities  Iq  Non-shared environment  Risk factors  Twins Index. décimale : PER Périodiques Résumé : BACKGROUND: A significant proportion of variation in likelihood of neurodevelopmental conditions (NDCs) has been attributed to nonshared environmental (NSE) factors, although it remains unclear which NSE factors pose specific risks for certain NDCs. METHODS: A monozygotic co-twin design was applied in a sample of 224 twins (mean age?=?17.70 years, SD?=?6.28) controlling for confounders such as genes and shared environment. Generalized estimating equation models were fitted, using perinatal and postnatal indications of NSEs as exposure, operationalized both as separate risk factors and as cumulative risk loads. Categorical and dimensional operationalizations of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), intellectual disability and other NDCs were used as outcomes. RESULTS: Birth weight discordance was associated with dimensional autism and ADHD for the smaller twin, and medication during infancy was associated with dimensional autism. Among postnatal factors scarlet fever during early childhood was associated with lower IQ. Especially autism was associated with a greater cumulative perinatal or postnatal risk load. LIMITATIONS: When exploring the associations between each condition and specific NSEs the risk of being statistically underpowered increases. Hence, we limit the reported findings on specific indicators of NSEs to trait levels and present descriptive data for categorical NDCs. CONCLUSIONS: The findings support previous research by indicating an association between exposure to perinatal and postnatal risks and subsequent NDCs within twin pairs and suggest that autism may be especially linked to accumulative early environmental risks. The findings are potentially important for developmental outcomes prognoses and may inform targeted prevention and early interventions. En ligne : http://dx.doi.org/10.1186/s13229-022-00487-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

The impact of atypical sensory processing on adaptive functioning within and beyond autism: The role of familial factors / J. NEUFELD in Autism, 25-8 (November 2021)  

Public ISBD [article]  inAutism > 25-8 (November 2021) . - p.2341-2355 Titre : The impact of atypical sensory processing on adaptive functioning within and beyond autism: The role of familial factors Type de document : Texte imprimé et/ou numérique Auteurs : J. NEUFELD, Auteur ; L. HEDEROS ERIKSSON, Auteur ; R. HAMMARSTEN, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; J. TILLMANN, Auteur ; J. ISAKSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.2341-2355 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Cognition  Humans  Perception  Sensation  adaptive functioning  autism  environment  familial factors  genetics  sensory hyper-responsiveness  sensory processing  twin design Index. décimale : PER Périodiques Résumé : Individuals diagnosed with autism tend to process sensory information differently than individuals without autism, resulting for instance in increased sensitivity to sounds or smells. This leads to challenges in everyday life and may restrict the individual's daily functioning. How direct this link is, however, is currently unclear. We investigated this question in 289 twins of whom 60 were diagnosed with autism and further 61 were diagnosed with other neurodevelopmental disorders. We looked at the association between unusual sensory processing and adaptive skills, both across individuals and within-twin pairs, testing whether individuals with higher levels of atypical sensory processing showed reduced adaptive skills compared to their twins. Since twins share 50%-100% of their genes and part of their environment (e.g. family background), associations within-twin pairs are free from effects of these familial factors. We found that an increased sensitivity to, as well as the avoiding of, sensory input (hyper-responsiveness) was linked to reduced adaptive skills across individuals-but not within-twin pairs. We also found an association between the degree to which individuals seek for sensory input (sensation seeking) and reduced adaptive skills, but only in individuals diagnosed with autism. The results suggest that sensory hyper-responsiveness has negative effects on individuals' general ability to function, but that this link is influenced by familial factors and hence not direct. In addition, sensation seeking behaviors might have a negative impact on adaptive skills specifically in autistic individuals. En ligne : http://dx.doi.org/10.1177/13623613211019852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] The impact of atypical sensory processing on adaptive functioning within and beyond autism: The role of familial factors [Texte imprimé et/ou numérique] / J. NEUFELD, Auteur ; L. HEDEROS ERIKSSON, Auteur ; R. HAMMARSTEN, Auteur ; K. LUNDIN REMNÉLIUS, Auteur ; J. TILLMANN, Auteur ; J. ISAKSSON, Auteur ; Sven BÖLTE, Auteur . - p.2341-2355. Langues : Anglais (eng) in Autism > 25-8 (November 2021) . - p.2341-2355 Mots-clés : Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Cognition  Humans  Perception  Sensation  adaptive functioning  autism  environment  familial factors  genetics  sensory hyper-responsiveness  sensory processing  twin design Index. décimale : PER Périodiques Résumé : Individuals diagnosed with autism tend to process sensory information differently than individuals without autism, resulting for instance in increased sensitivity to sounds or smells. This leads to challenges in everyday life and may restrict the individual's daily functioning. How direct this link is, however, is currently unclear. We investigated this question in 289 twins of whom 60 were diagnosed with autism and further 61 were diagnosed with other neurodevelopmental disorders. We looked at the association between unusual sensory processing and adaptive skills, both across individuals and within-twin pairs, testing whether individuals with higher levels of atypical sensory processing showed reduced adaptive skills compared to their twins. Since twins share 50%-100% of their genes and part of their environment (e.g. family background), associations within-twin pairs are free from effects of these familial factors. We found that an increased sensitivity to, as well as the avoiding of, sensory input (hyper-responsiveness) was linked to reduced adaptive skills across individuals-but not within-twin pairs. We also found an association between the degree to which individuals seek for sensory input (sensation seeking) and reduced adaptive skills, but only in individuals diagnosed with autism. The results suggest that sensory hyper-responsiveness has negative effects on individuals' general ability to function, but that this link is influenced by familial factors and hence not direct. In addition, sensation seeking behaviors might have a negative impact on adaptive skills specifically in autistic individuals. En ligne : http://dx.doi.org/10.1177/13623613211019852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

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