Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms / Naomi O. DAVIS ; Marina SPANOS ; Maura SABATOS-DEVITO ; Rachel AIELLO ; Grace T. BARANEK ; Scott N. COMPTON ; Helen L. EGGER ; Lauren FRANZ ; Soo-Jeong KIM ; Bryan H. KING ; Alexander KOLEVZON ; Christopher J. MCDOUGLE ; Kevin SANDERS ; Jeremy VEENSTRA-VANDERWEELE ; Linmarie SIKICH ; Scott H. KOLLINS ; Geraldine DAWSON in Journal of Autism and Developmental Disorders, 54-9 (September 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-9 (September 2024) . - p.3559-3566 Titre : Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Naomi O. DAVIS, Auteur ; Marina SPANOS, Auteur ; Maura SABATOS-DEVITO, Auteur ; Rachel AIELLO, Auteur ; Grace T. BARANEK, Auteur ; Scott N. COMPTON, Auteur ; Helen L. EGGER, Auteur ; Lauren FRANZ, Auteur ; Soo-Jeong KIM, Auteur ; Bryan H. KING, Auteur ; Alexander KOLEVZON, Auteur ; Christopher J. MCDOUGLE, Auteur ; Kevin SANDERS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Linmarie SIKICH, Auteur ; Scott H. KOLLINS, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.3559-3566 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) symptoms affect 40-60% of autistic children and have been linked to differences in adaptive behavior. It is unclear whether adaptive behavior in autistic youth is directly impacted by co-occurring ADHD symptoms or by another associated feature of both autism and ADHD, such as increased irritability. The current study examined relationships between irritability, ADHD symptoms, and adaptive behavior in 3- to 7-year-old autistic children. Results suggest that, after adjusting for co-occurring ADHD symptoms, higher levels of irritability are associated with differences in social adaptive behavior specifically. Understanding relationships between irritability, ADHD, and adaptive behavior in autistic children is critical because measures of adaptive behavior, such as the Vineland Scales of Adaptive Functioning, are often used as a proxy for global functioning, as well as for developing intervention plans and measuring outcomes as primary endpoints in clinical trials. En ligne : https://doi.org/10.1007/s10803-022-05753-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms [Texte imprimé et/ou numérique] / Naomi O. DAVIS, Auteur ; Marina SPANOS, Auteur ; Maura SABATOS-DEVITO, Auteur ; Rachel AIELLO, Auteur ; Grace T. BARANEK, Auteur ; Scott N. COMPTON, Auteur ; Helen L. EGGER, Auteur ; Lauren FRANZ, Auteur ; Soo-Jeong KIM, Auteur ; Bryan H. KING, Auteur ; Alexander KOLEVZON, Auteur ; Christopher J. MCDOUGLE, Auteur ; Kevin SANDERS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Linmarie SIKICH, Auteur ; Scott H. KOLLINS, Auteur ; Geraldine DAWSON, Auteur . - p.3559-3566. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-9 (September 2024) . - p.3559-3566 Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) symptoms affect 40-60% of autistic children and have been linked to differences in adaptive behavior. It is unclear whether adaptive behavior in autistic youth is directly impacted by co-occurring ADHD symptoms or by another associated feature of both autism and ADHD, such as increased irritability. The current study examined relationships between irritability, ADHD symptoms, and adaptive behavior in 3- to 7-year-old autistic children. Results suggest that, after adjusting for co-occurring ADHD symptoms, higher levels of irritability are associated with differences in social adaptive behavior specifically. Understanding relationships between irritability, ADHD, and adaptive behavior in autistic children is critical because measures of adaptive behavior, such as the Vineland Scales of Adaptive Functioning, are often used as a proxy for global functioning, as well as for developing intervention plans and measuring outcomes as primary endpoints in clinical trials. En ligne : https://doi.org/10.1007/s10803-022-05753-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome / Lauren M. MCGRATH in Journal of Autism and Developmental Disorders, 46-6 (June 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2174-2185 Titre : Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. MCGRATH, Auteur ; Joyce M. OATES, Auteur ; Yael G. DAI, Auteur ; Helen F. DODD, Auteur ; Jessica L. WAXLER, Auteur ; Caitlin C. CLEMENTS, Auteur ; Sydney WEILL, Auteur ; Alison HOFFNAGLE, Auteur ; Erin ANDERSON, Auteur ; Rebecca MACRAE, Auteur ; Jennifer MULLETT, Auteur ; Christopher J. MCDOUGLE, Auteur ; Barbara R. POBER, Auteur ; Jordan W. SMOLLER, Auteur Article en page(s) : p.2174-2185 Langues : Anglais (eng) Mots-clés : Williams syndrome  Anxiety  Attention bias  Social dot-probe  Emotional faces Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) often experience significant anxiety. A promising approach to anxiety intervention has emerged from cognitive studies of attention bias to threat. To investigate the utility of this intervention in WS, this study examined attention bias to happy and angry faces in individuals with WS (N = 46). Results showed a significant difference in attention bias patterns as a function of IQ and anxiety. Individuals with higher IQ or higher anxiety showed a significant bias toward angry, but not happy faces, whereas individuals with lower IQ or lower anxiety showed the opposite pattern. These results suggest that attention bias interventions to modify a threat bias may be most effectively targeted to anxious individuals with WS with relatively high IQ. En ligne : http://dx.doi.org/10.1007/s10803-016-2748-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome [Texte imprimé et/ou numérique] / Lauren M. MCGRATH, Auteur ; Joyce M. OATES, Auteur ; Yael G. DAI, Auteur ; Helen F. DODD, Auteur ; Jessica L. WAXLER, Auteur ; Caitlin C. CLEMENTS, Auteur ; Sydney WEILL, Auteur ; Alison HOFFNAGLE, Auteur ; Erin ANDERSON, Auteur ; Rebecca MACRAE, Auteur ; Jennifer MULLETT, Auteur ; Christopher J. MCDOUGLE, Auteur ; Barbara R. POBER, Auteur ; Jordan W. SMOLLER, Auteur . - p.2174-2185. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2174-2185 Mots-clés : Williams syndrome  Anxiety  Attention bias  Social dot-probe  Emotional faces Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) often experience significant anxiety. A promising approach to anxiety intervention has emerged from cognitive studies of attention bias to threat. To investigate the utility of this intervention in WS, this study examined attention bias to happy and angry faces in individuals with WS (N = 46). Results showed a significant difference in attention bias patterns as a function of IQ and anxiety. Individuals with higher IQ or higher anxiety showed a significant bias toward angry, but not happy faces, whereas individuals with lower IQ or lower anxiety showed the opposite pattern. These results suggest that attention bias interventions to modify a threat bias may be most effectively targeted to anxious individuals with WS with relatively high IQ. En ligne : http://dx.doi.org/10.1007/s10803-016-2748-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Autism and immune factors: A comprehensive review / Kimberly A. STIGLER in Research in Autism Spectrum Disorders, 3-4 (October-December 2009)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 3-4 (October-December 2009) . - p.840-860 Titre : Autism and immune factors: A comprehensive review Type de document : Texte imprimé et/ou numérique Auteurs : Kimberly A. STIGLER, Auteur ; Thayne L. SWEETEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; David J. POSEY, Auteur Année de publication : 2009 Article en page(s) : p.840-860 Langues : Anglais (eng) Mots-clés : Autism Immune Infection Immunogenetics Cytokines Gastrointestinal Autoimmune Index. décimale : PER Périodiques Résumé : Cases of autistic disorder (autism) have frequently been reported in association with congenital rubella and other infections. These observations stimulated further investigation into markers of immune function in autism. Postinfectious and autoimmune mechanisms of pathophysiology have been proposed. This review comprehensively addresses immune findings to date, including the role of viruses, neuroimmune factors, cellular and humoral immunity, immunogenetics, and immunotherapy in relation to autism. Although numerous immune abnormalities have been identified in autism, inconsistent results have often been reported. To date, research in this area has largely involved small, uncontrolled studies. In order to bring clarity to this field, high-quality, systematic research is needed to explore the role of neuroimmunologic factors in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.01.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=816 [article] Autism and immune factors: A comprehensive review [Texte imprimé et/ou numérique] / Kimberly A. STIGLER, Auteur ; Thayne L. SWEETEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; David J. POSEY, Auteur . - 2009 . - p.840-860. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 3-4 (October-December 2009) . - p.840-860 Mots-clés : Autism Immune Infection Immunogenetics Cytokines Gastrointestinal Autoimmune Index. décimale : PER Périodiques Résumé : Cases of autistic disorder (autism) have frequently been reported in association with congenital rubella and other infections. These observations stimulated further investigation into markers of immune function in autism. Postinfectious and autoimmune mechanisms of pathophysiology have been proposed. This review comprehensively addresses immune findings to date, including the role of viruses, neuroimmune factors, cellular and humoral immunity, immunogenetics, and immunotherapy in relation to autism. Although numerous immune abnormalities have been identified in autism, inconsistent results have often been reported. To date, research in this area has largely involved small, uncontrolled studies. In order to bring clarity to this field, high-quality, systematic research is needed to explore the role of neuroimmunologic factors in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.01.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=816

Beware of Over-Interpreting Negative Trials / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 38-9 (October 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-9 (October 2008) . - p.1609-1610 Titre : Beware of Over-Interpreting Negative Trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Benedetto VITIELLO, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2008 Article en page(s) : p.1609-1610 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0581-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=604 [article] Beware of Over-Interpreting Negative Trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Benedetto VITIELLO, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; James T. MCCRACKEN, Auteur . - 2008 . - p.1609-1610. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-9 (October 2008) . - p.1609-1610 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0581-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=604

Brief Report: Acamprosate in Fragile X Syndrome / Craig ERICKSON in Journal of Autism and Developmental Disorders, 40-11 (November 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1412-1416 Titre : Brief Report: Acamprosate in Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Craig ERICKSON, Auteur ; Jennifer E. MULLETT, Auteur ; Christopher J. MCDOUGLE, Auteur Année de publication : 2010 Article en page(s) : p.1412-1416 Langues : Anglais (eng) Mots-clés : Acamprosate  Fragile X syndrome  mGluR5  Language  Irritability Index. décimale : PER Périodiques Résumé : Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome (FXS). We report on the first trial of acamprosate, a drug with putative mGluR5 antagonism, in three adults with FXS and autism. Medical records describing open-label treatment with acamprosate in 3 patients with FXS and a comorbid diagnosis of autistic disorder were reviewed. In all three patients, acamprosate was associated with improved linguistic communication. Three patients received acamprosate over a mean 21.3 weeks of treatment. All patients showed global clinical benefit as rated with the Clinical Global Impressions-Improvement scale. Marked communication improvement was unexpected and has potential implications for the treatment of FXS, as well as idiopathic autism. En ligne : http://dx.doi.org/10.1007/s10803-010-0988-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Brief Report: Acamprosate in Fragile X Syndrome [Texte imprimé et/ou numérique] / Craig ERICKSON, Auteur ; Jennifer E. MULLETT, Auteur ; Christopher J. MCDOUGLE, Auteur . - 2010 . - p.1412-1416. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1412-1416 Mots-clés : Acamprosate  Fragile X syndrome  mGluR5  Language  Irritability Index. décimale : PER Périodiques Résumé : Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome (FXS). We report on the first trial of acamprosate, a drug with putative mGluR5 antagonism, in three adults with FXS and autism. Medical records describing open-label treatment with acamprosate in 3 patients with FXS and a comorbid diagnosis of autistic disorder were reviewed. In all three patients, acamprosate was associated with improved linguistic communication. Three patients received acamprosate over a mean 21.3 weeks of treatment. All patients showed global clinical benefit as rated with the Clinical Global Impressions-Improvement scale. Marked communication improvement was unexpected and has potential implications for the treatment of FXS, as well as idiopathic autism. En ligne : http://dx.doi.org/10.1007/s10803-010-0988-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Brief Report: Autism Spectrum Disorder and Substance Use Disorder: A Review and Case Study / Ashy C. RENGIT in Journal of Autism and Developmental Disorders, 46-7 (July 2016)  

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Brief Report: Bone Fractures in Children and Adults with Autism Spectrum Disorders / Ann M. NEUMEYER in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

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Brief Report: Pilot Single-Blind Placebo Lead-In Study of Acamprosate in Youth with Autistic Disorder / Craig ERICKSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

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Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

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Brief Report: Suspected Cannabis-Induced Mania and Psychosis in Young Adult Males with Autism Spectrum Disorder / Majd AL-SOLEITI in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

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Case Report: 16-Year-Old Male with Autistic Disorder with Preoccupation with Female Feet / Maureen C. EARLY in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

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Case Reports: Clozapine for the Treatment of Catatonia in Autism Spectrum Disorder / Robyn P. THOM in Journal of Autism and Developmental Disorders, 52-6 (June 2022)  

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Differences in verbal and nonverbal IQ test scores in children with autism spectrum disorder / Sabrina N. GRONDHUIS in Research in Autism Spectrum Disorders, 49 (May 2018)  

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Diversity of Participants in Williams Syndrome Intervention Studies / Eva SHIN in Journal of Autism and Developmental Disorders, 54-10 (October 2024)  

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A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder / Benjamin L. HANDEN in Journal of Autism and Developmental Disorders, 39-5 (May 2009)  

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