Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467 Titre : Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur Année de publication : 2012 Article en page(s) : p.460-467 Langues : Anglais (eng) Mots-clés : Autism  Asperger syndrome  Life history  Neuropathology  Adult Index. décimale : PER Périodiques Résumé : Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. En ligne : http://dx.doi.org/10.1007/s10803-011-1259-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur . - 2012 . - p.460-467. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467 Mots-clés : Autism  Asperger syndrome  Life history  Neuropathology  Adult Index. décimale : PER Périodiques Résumé : Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. En ligne : http://dx.doi.org/10.1007/s10803-011-1259-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders / Roumen N. NIKOLOV in Journal of Autism and Developmental Disorders, 39-3 (March 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.405-413 Titre : Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Roumen N. NIKOLOV, Auteur ; Lawrence SCAHILL, Auteur ; Bhavik SHAH, Auteur ; Maria RODOWSKI, Auteur ; Craig ERICKSON, Auteur ; Jelle LETTINGA, Auteur ; Karen E. BEARSS, Auteur ; David J. POSEY, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.405-413 Langues : Anglais (eng) Mots-clés : Autism Chronic-gastrointestinal-problems Pervasive-developmental-disorders Index. décimale : PER Périodiques Résumé : Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment. En ligne : http://dx.doi.org/10.1007/s10803-008-0637-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695 [article] Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Roumen N. NIKOLOV, Auteur ; Lawrence SCAHILL, Auteur ; Bhavik SHAH, Auteur ; Maria RODOWSKI, Auteur ; Craig ERICKSON, Auteur ; Jelle LETTINGA, Auteur ; Karen E. BEARSS, Auteur ; David J. POSEY, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.405-413. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.405-413 Mots-clés : Autism Chronic-gastrointestinal-problems Pervasive-developmental-disorders Index. décimale : PER Périodiques Résumé : Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment. En ligne : http://dx.doi.org/10.1007/s10803-008-0637-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695

Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity / Laudan B. JAHROMI in Journal of Autism and Developmental Disorders, 39-3 (March 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.395-404 Titre : Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity Type de document : Texte imprimé et/ou numérique Auteurs : Laudan B. JAHROMI, Auteur ; Connie KASARI, Auteur ; David J. POSEY, Auteur ; Jaswinder GHUMAN, Auteur ; Erin KUSTAN, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Lisa S-Y. LEE, Auteur ; Andrea N. WITWER, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.395-404 Langues : Anglais (eng) Mots-clés : Methylphenidate Pervasive-developmental-disorders Hyperactivity Autism-spectrum-disorder Index. décimale : PER Périodiques Résumé : This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children’s social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children’s use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity. En ligne : http://dx.doi.org/10.1007/s10803-008-0636-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695 [article] Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity [Texte imprimé et/ou numérique] / Laudan B. JAHROMI, Auteur ; Connie KASARI, Auteur ; David J. POSEY, Auteur ; Jaswinder GHUMAN, Auteur ; Erin KUSTAN, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Lisa S-Y. LEE, Auteur ; Andrea N. WITWER, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.395-404. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.395-404 Mots-clés : Methylphenidate Pervasive-developmental-disorders Hyperactivity Autism-spectrum-disorder Index. décimale : PER Périodiques Résumé : This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children’s social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children’s use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity. En ligne : http://dx.doi.org/10.1007/s10803-008-0636-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695

Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 39-5 (May 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.720-729 Titre : Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Kimberly A. STIGLER, Auteur ; James MULICK, Auteur ; Eric BUTTER, Auteur ; James DZIURA, Auteur ; Cynthia JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Louise RITZ, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi SWIEZY, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Ann WAGNER, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.720-729 Langues : Anglais (eng) Mots-clés : Autism Clinical-trial-methodology Risperidone Behavior-therapy Index. décimale : PER Périodiques Résumé : This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice. En ligne : http://dx.doi.org/10.1007/s10803-008-0675-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732 [article] Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Kimberly A. STIGLER, Auteur ; James MULICK, Auteur ; Eric BUTTER, Auteur ; James DZIURA, Auteur ; Cynthia JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Louise RITZ, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi SWIEZY, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Ann WAGNER, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.720-729. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.720-729 Mots-clés : Autism Clinical-trial-methodology Risperidone Behavior-therapy Index. décimale : PER Périodiques Résumé : This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice. En ligne : http://dx.doi.org/10.1007/s10803-008-0675-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732

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