Are Stimulants Useful in ASC? / L. Eugene ARNOLD

Public ISBD in Autism Spectrum Conditions / Sven BÖLTE Titre : Are Stimulants Useful in ASC? Type de document : Texte imprimé et/ou numérique Auteurs : L. Eugene ARNOLD, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur Année de publication : 2011 Importance : p.217-219 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Conditions / Sven BÖLTE Are Stimulants Useful in ASC? [Texte imprimé et/ou numérique] / L. Eugene ARNOLD, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur . - 2011 . - p.217-219. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Assessing medication effects in the MTA study using neuropsychological outcomes / Jeffery N. EPSTEIN in Journal of Child Psychology and Psychiatry, 47-5 (May 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-5 (May 2006) . - p.446–456 Titre : Assessing medication effects in the MTA study using neuropsychological outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Jeffery N. EPSTEIN, Auteur ; Peter S. JENSEN, Auteur ; John S. MARCH, Auteur ; Jeffrey H. NEWCORN, Auteur ; William E. PELHAM, Auteur ; Joanne B. SEVERE, Auteur ; James M. SWANSON, Auteur ; Karen WELLS, Auteur ; Benedetto VITIELLO, Auteur ; Betsy HOZA, Auteur ; Stephen P. HINSHAW, Auteur ; Kimberly HOAGWOOD, Auteur ; C. Keith CONNERS, Auteur ; Aaron S. HERVEY, Auteur ; Simon T. TONEV, Auteur ; L. Eugene ARNOLD, Auteur ; Howard B. ABIKOFF, Auteur ; Glen ELLIOTT, Auteur ; Laurence L. GREENHILL, Auteur ; Lily HECHTMAN, Auteur ; Timothy WIGAL, Auteur Année de publication : 2006 Article en page(s) : p.446–456 Langues : Anglais (eng) Mots-clés : ADHD/ADD go/no-go-test stimulants reaction-time distributions neuropsychology pharmacology Index. décimale : PER Périodiques Résumé : Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01469.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=730 [article] Assessing medication effects in the MTA study using neuropsychological outcomes [Texte imprimé et/ou numérique] / Jeffery N. EPSTEIN, Auteur ; Peter S. JENSEN, Auteur ; John S. MARCH, Auteur ; Jeffrey H. NEWCORN, Auteur ; William E. PELHAM, Auteur ; Joanne B. SEVERE, Auteur ; James M. SWANSON, Auteur ; Karen WELLS, Auteur ; Benedetto VITIELLO, Auteur ; Betsy HOZA, Auteur ; Stephen P. HINSHAW, Auteur ; Kimberly HOAGWOOD, Auteur ; C. Keith CONNERS, Auteur ; Aaron S. HERVEY, Auteur ; Simon T. TONEV, Auteur ; L. Eugene ARNOLD, Auteur ; Howard B. ABIKOFF, Auteur ; Glen ELLIOTT, Auteur ; Laurence L. GREENHILL, Auteur ; Lily HECHTMAN, Auteur ; Timothy WIGAL, Auteur . - 2006 . - p.446–456. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-5 (May 2006) . - p.446–456 Mots-clés : ADHD/ADD go/no-go-test stimulants reaction-time distributions neuropsychology pharmacology Index. décimale : PER Périodiques Résumé : Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01469.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=730

Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.739-746 Titre : Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Victoria HALLETT, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Yanhong DENG, Auteur ; James DZIURA, Auteur ; Benedetto VITIELLO, Auteur Article en page(s) : p.739-746 Langues : Anglais (eng) Mots-clés : Social disability  Autism  Research Units on Pediatric Psychopharmacology (RUPP)  Autism Network  Social withdrawal  Risperidone  Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. En ligne : http://dx.doi.org/10.1007/s10803-012-1689-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Victoria HALLETT, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Yanhong DENG, Auteur ; James DZIURA, Auteur ; Benedetto VITIELLO, Auteur . - p.739-746. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.739-746 Mots-clés : Social disability  Autism  Research Units on Pediatric Psychopharmacology (RUPP)  Autism Network  Social withdrawal  Risperidone  Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. En ligne : http://dx.doi.org/10.1007/s10803-012-1689-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

Controlled randomized crossover of essential oils for quality of life in children with autism spectrum disorder (ASD): A pilot and feasibility study / Xueliang PAN ; Taylor WONG ; Craig WILLIAMS ; Cheryl JAMES ; L. Eugene ARNOLD in Research in Autism, 125 (July 2025)  

Public ISBD [article]  inResearch in Autism > 125 (July 2025) . - p.202603 Titre : Controlled randomized crossover of essential oils for quality of life in children with autism spectrum disorder (ASD): A pilot and feasibility study Type de document : Texte imprimé et/ou numérique Auteurs : Xueliang PAN, Auteur ; Taylor WONG, Auteur ; Craig WILLIAMS, Auteur ; Cheryl JAMES, Auteur ; L. Eugene ARNOLD, Auteur Article en page(s) : p.202603 Langues : Anglais (eng) Mots-clés : Essential oils  Autism spectrum disorder  Feasibility study  Quality of life  Sleep  Anxiety  Proinflammatory cytokines Index. décimale : PER Périodiques Résumé : Introduction Essential oils have been touted to benefit children with autism spectrum disorder (ASD) in a multitude of ways. However, the lack of empirical evidence makes it difficult to accept this claim. We tested the feasibility of conducting a large randomized clinical crossover trial of an essential oils blend in children with ASD and evaluated its safety and efficacy for improving quality of life. Methods Children ages 3-9 with ASD were randomized to a crossover study of Reconnect?, an essential oils blend, versus a control. Outcomes were the Pediatric Quality of Life Inventory, Parent-Rated Anxiety Scale for ASD, Children?s Sleep Habits Questionnaire, and laboratory safety tests. Inflammatory cytokines and other labs were explored. Mixed-effects analyses were applied. Results Twenty-six participants evaluated as intent-to-treat population. Seventeen completed both conditions (61 %). Outcomes improved, but between-treatment differences in the crossover were nonsignificant (p = .33-.16). At first treatment endpoint, anxiety decreased significantly more with active than control (p = .015, d=1.01). Adverse events and hematological/hepatic/renal tests revealed no significant differences. C-reactive protein and interleukin-6 (IL-6) revealed no inflammation. Conclusion Recruitment was feasible, adherence was high, first-condition retention was high (92.7 %). Retention in second condition was low (65.4 %). A large crossover is not feasible. Anxiety results suggest further study in a randomized controlled trial with a parallel-groups design. Reconnect? appears safe. En ligne : https://doi.org/10.1016/j.reia.2025.202603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Controlled randomized crossover of essential oils for quality of life in children with autism spectrum disorder (ASD): A pilot and feasibility study [Texte imprimé et/ou numérique] / Xueliang PAN, Auteur ; Taylor WONG, Auteur ; Craig WILLIAMS, Auteur ; Cheryl JAMES, Auteur ; L. Eugene ARNOLD, Auteur . - p.202603. Langues : Anglais (eng) in Research in Autism > 125 (July 2025) . - p.202603 Mots-clés : Essential oils  Autism spectrum disorder  Feasibility study  Quality of life  Sleep  Anxiety  Proinflammatory cytokines Index. décimale : PER Périodiques Résumé : Introduction Essential oils have been touted to benefit children with autism spectrum disorder (ASD) in a multitude of ways. However, the lack of empirical evidence makes it difficult to accept this claim. We tested the feasibility of conducting a large randomized clinical crossover trial of an essential oils blend in children with ASD and evaluated its safety and efficacy for improving quality of life. Methods Children ages 3-9 with ASD were randomized to a crossover study of Reconnect?, an essential oils blend, versus a control. Outcomes were the Pediatric Quality of Life Inventory, Parent-Rated Anxiety Scale for ASD, Children?s Sleep Habits Questionnaire, and laboratory safety tests. Inflammatory cytokines and other labs were explored. Mixed-effects analyses were applied. Results Twenty-six participants evaluated as intent-to-treat population. Seventeen completed both conditions (61 %). Outcomes improved, but between-treatment differences in the crossover were nonsignificant (p = .33-.16). At first treatment endpoint, anxiety decreased significantly more with active than control (p = .015, d=1.01). Adverse events and hematological/hepatic/renal tests revealed no significant differences. C-reactive protein and interleukin-6 (IL-6) revealed no inflammation. Conclusion Recruitment was feasible, adherence was high, first-condition retention was high (92.7 %). Retention in second condition was low (65.4 %). A large crossover is not feasible. Anxiety results suggest further study in a randomized controlled trial with a parallel-groups design. Reconnect? appears safe. En ligne : https://doi.org/10.1016/j.reia.2025.202603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity / Margaret H. SIBLEY in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.655-662 Titre : Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity Type de document : Texte imprimé et/ou numérique Auteurs : Margaret H. SIBLEY, Auteur ; James M. SWANSON, Auteur ; L. Eugene ARNOLD, Auteur ; Lily T. HECHTMAN, Auteur ; Elizabeth B. OWENS, Auteur ; Annamarie STEHLI, Auteur ; Howard B. ABIKOFF, Auteur ; Stephen P. HINSHAW, Auteur ; Brooke S. G. MOLINA, Auteur ; John T. MITCHELL, Auteur ; Peter S. JENSEN, Auteur ; Andrea L. HOWARD, Auteur ; Kimberley D. LAKES, Auteur ; William E. PELHAM, Auteur ; THE M. T. A. COOPERATIVE GROUP,, Auteur Article en page(s) : p.655-662 Langues : Anglais (eng) Mots-clés : Adult ADHD  DSM-5  diagnosis Index. décimale : PER Périodiques Résumé : Objective Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5–75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. Method Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0–9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood. Results Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold. Conclusion The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an ‘or’ rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.12620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity [Texte imprimé et/ou numérique] / Margaret H. SIBLEY, Auteur ; James M. SWANSON, Auteur ; L. Eugene ARNOLD, Auteur ; Lily T. HECHTMAN, Auteur ; Elizabeth B. OWENS, Auteur ; Annamarie STEHLI, Auteur ; Howard B. ABIKOFF, Auteur ; Stephen P. HINSHAW, Auteur ; Brooke S. G. MOLINA, Auteur ; John T. MITCHELL, Auteur ; Peter S. JENSEN, Auteur ; Andrea L. HOWARD, Auteur ; Kimberley D. LAKES, Auteur ; William E. PELHAM, Auteur ; THE M. T. A. COOPERATIVE GROUP,, Auteur . - p.655-662. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.655-662 Mots-clés : Adult ADHD  DSM-5  diagnosis Index. décimale : PER Périodiques Résumé : Objective Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5–75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. Method Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0–9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood. Results Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold. Conclusion The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an ‘or’ rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.12620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Development of bipolar disorder and other comorbidity among youth with attention-deficit/hyperactivity disorder / L. Eugene ARNOLD in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

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Developmental processes in peer problems of children with attention-deficit/hyperactivity disorder in The Multimodal Treatment Study of Children With ADHD: Developmental cascades and vicious cycles / Dianna MURRAY-CLOSE in Development and Psychopathology, 22-4 (November 2010)  

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Developmental processes in peer problems of children with attention-deficit/hyperactivity disorder in The Multimodal Treatment Study of Children With ADHD: Developmental cascades and vicious cycles—CORRIGENDUM / Dianna MURRAY-CLOSE in Development and Psychopathology, 26-1 (February 2014)  

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Differences in verbal and nonverbal IQ test scores in children with autism spectrum disorder / Sabrina N. GRONDHUIS in Research in Autism Spectrum Disorders, 49 (May 2018)  

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Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders / Roumen N. NIKOLOV in Journal of Autism and Developmental Disorders, 39-3 (March 2009)  

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A multisite trial of atomoxetine and parent training in children with autism spectrum disorders: Rationale and design challenges / Laura SILVERMAN in Research in Autism Spectrum Disorders, 8-7 (July 2014)  

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Neurofeedback Treatment for Autism Spectrum Disorder / Justin A. BARTERIAN

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Omega-3 supplementation associated with improved parent-rated executive function in youth with mood disorders: secondary analyses of the omega 3 and therapy (OATS) trials / A. T. VESCO in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

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Parent-Reported Homework Problems in the MTA Study: Evidence for Sustained Improvement with Behavioral Treatment / Joshua M. LANGBERG in Journal of Clinical Child & Adolescent Psychology, 39-2 (March-April 2010)  

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Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder / L. LECAVALIER in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

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