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Auteur Yona LUNSKY |
Documents disponibles écrits par cet auteur (22)
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Polypharmacy profiles and predictors among adults with autism spectrum disorders / Johanna K. LAKE in Research in Autism Spectrum Disorders, 6-3 (July-September 2012)
[article]
Titre : Polypharmacy profiles and predictors among adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Johanna K. LAKE, Auteur ; Robert BALOGH, Auteur ; Yona LUNSKY, Auteur Année de publication : 2012 Article en page(s) : p.1142-1149 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Medication Polypharmacy Psychotropic medication Index. décimale : PER Périodiques Résumé : Pharmacological interventions are frequently used to treat commonly associated mental health and behavioural issues in individuals with autism spectrum disorders (ASD). Despite high rates of psychotropic drug use documented in children with ASD, very few studies have examined medication profiles, side effects, and rates of polypharmacy in adolescents and adults with ASD. To address this, we examined medication profiles and predictors of polypharmacy among 142 adults with ASD who had experienced a psychiatric crisis. Of the 142 adults sampled, 91 (64.1%) were prescribed at least 1 psychotropic medication and 41 (28.9%) were taking 3 or more psychotropic medications. Variables associated with and predictive of polypharmacy included history of aggression, residence, and psychiatric support. Adults with ASD are a highly medicated population and polypharmacy is a significant concern in this vulnerable group of individuals. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Research in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.1142-1149[article] Polypharmacy profiles and predictors among adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Johanna K. LAKE, Auteur ; Robert BALOGH, Auteur ; Yona LUNSKY, Auteur . - 2012 . - p.1142-1149.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.1142-1149
Mots-clés : Autism spectrum disorder Medication Polypharmacy Psychotropic medication Index. décimale : PER Périodiques Résumé : Pharmacological interventions are frequently used to treat commonly associated mental health and behavioural issues in individuals with autism spectrum disorders (ASD). Despite high rates of psychotropic drug use documented in children with ASD, very few studies have examined medication profiles, side effects, and rates of polypharmacy in adolescents and adults with ASD. To address this, we examined medication profiles and predictors of polypharmacy among 142 adults with ASD who had experienced a psychiatric crisis. Of the 142 adults sampled, 91 (64.1%) were prescribed at least 1 psychotropic medication and 41 (28.9%) were taking 3 or more psychotropic medications. Variables associated with and predictive of polypharmacy included history of aggression, residence, and psychiatric support. Adults with ASD are a highly medicated population and polypharmacy is a significant concern in this vulnerable group of individuals. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 Predictors of Changes in Daily Activity in Transition-Age Autistic Youth / Jonathan A WEISS in Autism Research, 14-2 (February 2021)
[article]
Titre : Predictors of Changes in Daily Activity in Transition-Age Autistic Youth Type de document : Texte imprimé et/ou numérique Auteurs : Jonathan A WEISS, Auteur ; Jonathan K. Y. LAI, Auteur ; Vivian LEE, Auteur ; Yona LUNSKY, Auteur Article en page(s) : p.324-332 Langues : Anglais (eng) Mots-clés : adulthood autism community employment schooling services transition-age youth Index. décimale : PER Périodiques Résumé : Transitioning into adulthood is fraught with challenges for autistic youth. A greater understanding of the facilitators of community involvement in school and employment during this period is warranted. The current study examines changes in service need and receipt, and the stability of accessing daily structured activities, for autistic young adults over their transition period compared to adolescents and adults that did not enter the transition period. Baseline caregiver survey data were taken from the Canadian Autism Spectrum Disorders Alliance National Autism Needs Assessment Survey in 2014, and caregivers (n = 304) completed the same set of questions in 2017 about sociodemographic factors, clinical need, service receipt and typical weekday activities. Three cohorts were compared: (1) pretransition age youth, (2) transition-age youth, and (3) young adults who were past transition age. Results suggest that transition-age youth were found to have a unique set of priority service needs compared to pre transition-age adolescent and to adult groups, and both transition-age and adult groups had lower levels of priority service receipt compared to pretransition-age adolescents. The transition-age group experienced the greatest loss of structured weekday activity between time points, and were more likely than pretransition-age adolescents to not have structured weekday activities at Time 2. A recovery of structured daily activity was not observed in young adults. Our results highlight the tumultuous nature of the transition period for autistic youth, which continues into adulthood, and the urgent need for supports during this time. LAY SUMMARY: This research highlights that autistic young people who are transitioning to adulthood are at greatest risk of losing structured weekday activities, and that once in adulthood, many continue to struggle to obtain meaningful community engagement. These results can help guide the design of adolescent and young adult transition programs. En ligne : http://dx.doi.org/10.1002/aur.2371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-2 (February 2021) . - p.324-332[article] Predictors of Changes in Daily Activity in Transition-Age Autistic Youth [Texte imprimé et/ou numérique] / Jonathan A WEISS, Auteur ; Jonathan K. Y. LAI, Auteur ; Vivian LEE, Auteur ; Yona LUNSKY, Auteur . - p.324-332.
Langues : Anglais (eng)
in Autism Research > 14-2 (February 2021) . - p.324-332
Mots-clés : adulthood autism community employment schooling services transition-age youth Index. décimale : PER Périodiques Résumé : Transitioning into adulthood is fraught with challenges for autistic youth. A greater understanding of the facilitators of community involvement in school and employment during this period is warranted. The current study examines changes in service need and receipt, and the stability of accessing daily structured activities, for autistic young adults over their transition period compared to adolescents and adults that did not enter the transition period. Baseline caregiver survey data were taken from the Canadian Autism Spectrum Disorders Alliance National Autism Needs Assessment Survey in 2014, and caregivers (n = 304) completed the same set of questions in 2017 about sociodemographic factors, clinical need, service receipt and typical weekday activities. Three cohorts were compared: (1) pretransition age youth, (2) transition-age youth, and (3) young adults who were past transition age. Results suggest that transition-age youth were found to have a unique set of priority service needs compared to pre transition-age adolescent and to adult groups, and both transition-age and adult groups had lower levels of priority service receipt compared to pretransition-age adolescents. The transition-age group experienced the greatest loss of structured weekday activity between time points, and were more likely than pretransition-age adolescents to not have structured weekday activities at Time 2. A recovery of structured daily activity was not observed in young adults. Our results highlight the tumultuous nature of the transition period for autistic youth, which continues into adulthood, and the urgent need for supports during this time. LAY SUMMARY: This research highlights that autistic young people who are transitioning to adulthood are at greatest risk of losing structured weekday activities, and that once in adulthood, many continue to struggle to obtain meaningful community engagement. These results can help guide the design of adolescent and young adult transition programs. En ligne : http://dx.doi.org/10.1002/aur.2371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 Predictors of health service use among adolescents and adults with autism and aggression / Melissa PAQUETTE-SMITH in Research in Autism Spectrum Disorders, 68 (December 2019)
[article]
Titre : Predictors of health service use among adolescents and adults with autism and aggression Type de document : Texte imprimé et/ou numérique Auteurs : Melissa PAQUETTE-SMITH, Auteur ; Jonathan A. WEISS, Auteur ; Julie DERGAL, Auteur ; Johanna LAKE, Auteur ; Yona LUNSKY, Auteur Article en page(s) : p.101418 Langues : Anglais (eng) Mots-clés : Health services Autism Adolescents Adults Psychotropic medication Psychosocial intervention Behavioral intervention Aggression Index. décimale : PER Périodiques Résumé : Background Clinical guidelines recommend that psychosocial interventions be used before medication to manage aggressive behavior in individuals with autism. However, the extent to which a multidisciplinary approach is implemented and the factors that influence service use in this complex population are not well understood. Methods In this study, parents of 182 adolescents and adults with autism and a history of aggression were asked to report on their child’s health service use every two months for a year. Individuals that used services in this time period (N?=?158) were classified into three groups: users of psychotropic medication alone (n?=?28, 17.7%); psychosocial services alone (n?=?33, 20.9%); or users of both (n?=?97, 61.4%). Results Although the majority of the sample (82.3%) received guideline recommended treatment (i.e., psychosocial services or a combination of psychosocial services and psychotropic medication), 17.7% were using psychotropic medication alone. Several enabling variables, including visiting a family physician in the two-months prior to baseline, having higher parental education, and having parents who reported being able to effectively access services predicted using psychosocial services alone or in combination with medication. Predisposing and need variables (i.e., being younger and having no psychiatric disorders) also predicted using psychosocial services compared to medication alone. Conclusions Understanding predictors of service use can help to identify and address barriers that may prevent adults with autism and aggression from accessing guideline recommended care. En ligne : https://doi.org/10.1016/j.rasd.2019.101418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407
in Research in Autism Spectrum Disorders > 68 (December 2019) . - p.101418[article] Predictors of health service use among adolescents and adults with autism and aggression [Texte imprimé et/ou numérique] / Melissa PAQUETTE-SMITH, Auteur ; Jonathan A. WEISS, Auteur ; Julie DERGAL, Auteur ; Johanna LAKE, Auteur ; Yona LUNSKY, Auteur . - p.101418.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 68 (December 2019) . - p.101418
Mots-clés : Health services Autism Adolescents Adults Psychotropic medication Psychosocial intervention Behavioral intervention Aggression Index. décimale : PER Périodiques Résumé : Background Clinical guidelines recommend that psychosocial interventions be used before medication to manage aggressive behavior in individuals with autism. However, the extent to which a multidisciplinary approach is implemented and the factors that influence service use in this complex population are not well understood. Methods In this study, parents of 182 adolescents and adults with autism and a history of aggression were asked to report on their child’s health service use every two months for a year. Individuals that used services in this time period (N?=?158) were classified into three groups: users of psychotropic medication alone (n?=?28, 17.7%); psychosocial services alone (n?=?33, 20.9%); or users of both (n?=?97, 61.4%). Results Although the majority of the sample (82.3%) received guideline recommended treatment (i.e., psychosocial services or a combination of psychosocial services and psychotropic medication), 17.7% were using psychotropic medication alone. Several enabling variables, including visiting a family physician in the two-months prior to baseline, having higher parental education, and having parents who reported being able to effectively access services predicted using psychosocial services alone or in combination with medication. Predisposing and need variables (i.e., being younger and having no psychiatric disorders) also predicted using psychosocial services compared to medication alone. Conclusions Understanding predictors of service use can help to identify and address barriers that may prevent adults with autism and aggression from accessing guideline recommended care. En ligne : https://doi.org/10.1016/j.rasd.2019.101418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407 Premature mortality in a population-based cohort of autistic adults in Canada / Yona LUNSKY in Autism Research, 15-8 (August 2022)
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Titre : Premature mortality in a population-based cohort of autistic adults in Canada Type de document : Texte imprimé et/ou numérique Auteurs : Yona LUNSKY, Auteur ; Meng-Chuan LAI, Auteur ; Robert BALOGH, Auteur ; Hannah CHUNG, Auteur ; Anna DURBIN, Auteur ; Patrick JACHYRA, Auteur ; Ami TINT, Auteur ; Jonathan WEISS, Auteur ; Elizabeth LIN, Auteur Article en page(s) : p.1550-1559 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/epidemiology Autistic Disorder/epidemiology Child Cohort Studies Developmental Disabilities/epidemiology Female Humans Infant, Newborn Male Mortality, Premature Ontario/epidemiology autism developmental disabilities premature mortality sex differences Index. décimale : PER Périodiques Résumé : Research from different countries suggests that autistic adults are more likely to die prematurely than non-autistic adults, but these studies do not always investigate male and female individuals separately and do not consider whether this pattern is unique to autistic people or is also an issue for people with other developmental disabilities. We examined premature mortality in autistic males and females (assigned at birth) in a population-based cohort, compared to males and females with and without other developmental disabilities. Using linked administrative health and social services population data from Ontario, Canada, age-matched males and females aged 19-65years were followed between 2010 and 2016, and causes of death were determined. Over the 6-year observation period, 330 of 42,607 persons (0.77%) in the group without developmental disabilities had died compared to 259 of 10,646 persons (2.43%) in the autism group and 419 of 10,615 persons (3.95%) in the other developmental disabilities group. Autistic males and females were more likely to die than non-autistic males (adjusted risk ratio, RR 3.13, 95%CI 2.58-3.79) and non-autistic females (adjusted RR 3.12, 95%CI 2.35-4.13) without developmental disabilities, but were less likely to die than adults with other developmental disabilities (males: adjusted RR 0.66, 95%CI 0.55-0.79; females: adjusted RR 0.55, 95%CI 0.43-0.71). Most common causes of death varied depending on a person's sex and diagnosis. Given the greater likelihood of premature mortality in adults with developmental disabilities including autism, greater attention and resources directed toward their health and social care are needed, tailored to their sex and diagnosis-informed needs. LAY SUMMARY: This study looked at how many autistic men and women died over 6years (2010-2016), along with how they died, and compared this to adults who did not have autism living in Ontario, Canada. It found that autistic men and women were more than three times as likely to die as people of the same age who did not have a developmental disability. However, adults with other developmental disabilities besides autism were even more likely to die than autistic adults. This means that we have to pay more attention and invest in better social and health care for autistic people, along with people who have other types of developmental disabilities. En ligne : http://dx.doi.org/10.1002/aur.2741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483
in Autism Research > 15-8 (August 2022) . - p.1550-1559[article] Premature mortality in a population-based cohort of autistic adults in Canada [Texte imprimé et/ou numérique] / Yona LUNSKY, Auteur ; Meng-Chuan LAI, Auteur ; Robert BALOGH, Auteur ; Hannah CHUNG, Auteur ; Anna DURBIN, Auteur ; Patrick JACHYRA, Auteur ; Ami TINT, Auteur ; Jonathan WEISS, Auteur ; Elizabeth LIN, Auteur . - p.1550-1559.
Langues : Anglais (eng)
in Autism Research > 15-8 (August 2022) . - p.1550-1559
Mots-clés : Adult Autism Spectrum Disorder/epidemiology Autistic Disorder/epidemiology Child Cohort Studies Developmental Disabilities/epidemiology Female Humans Infant, Newborn Male Mortality, Premature Ontario/epidemiology autism developmental disabilities premature mortality sex differences Index. décimale : PER Périodiques Résumé : Research from different countries suggests that autistic adults are more likely to die prematurely than non-autistic adults, but these studies do not always investigate male and female individuals separately and do not consider whether this pattern is unique to autistic people or is also an issue for people with other developmental disabilities. We examined premature mortality in autistic males and females (assigned at birth) in a population-based cohort, compared to males and females with and without other developmental disabilities. Using linked administrative health and social services population data from Ontario, Canada, age-matched males and females aged 19-65years were followed between 2010 and 2016, and causes of death were determined. Over the 6-year observation period, 330 of 42,607 persons (0.77%) in the group without developmental disabilities had died compared to 259 of 10,646 persons (2.43%) in the autism group and 419 of 10,615 persons (3.95%) in the other developmental disabilities group. Autistic males and females were more likely to die than non-autistic males (adjusted risk ratio, RR 3.13, 95%CI 2.58-3.79) and non-autistic females (adjusted RR 3.12, 95%CI 2.35-4.13) without developmental disabilities, but were less likely to die than adults with other developmental disabilities (males: adjusted RR 0.66, 95%CI 0.55-0.79; females: adjusted RR 0.55, 95%CI 0.43-0.71). Most common causes of death varied depending on a person's sex and diagnosis. Given the greater likelihood of premature mortality in adults with developmental disabilities including autism, greater attention and resources directed toward their health and social care are needed, tailored to their sex and diagnosis-informed needs. LAY SUMMARY: This study looked at how many autistic men and women died over 6years (2010-2016), along with how they died, and compared this to adults who did not have autism living in Ontario, Canada. It found that autistic men and women were more than three times as likely to die as people of the same age who did not have a developmental disability. However, adults with other developmental disabilities besides autism were even more likely to die than autistic adults. This means that we have to pay more attention and invest in better social and health care for autistic people, along with people who have other types of developmental disabilities. En ligne : http://dx.doi.org/10.1002/aur.2741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review / Amanda SAWYER in Research in Autism Spectrum Disorders, 8-7 (July 2014)
[article]
Titre : Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Amanda SAWYER, Auteur ; Johanna K. LAKE, Auteur ; Yona LUNSKY, Auteur ; Shi-Kai LIU, Auteur ; Pushpal DESARKAR, Auteur Article en page(s) : p.803-813 Langues : Anglais (eng) Mots-clés : Autism Adults Challenging behaviours Psychopharmacology Intellectual disability Index. décimale : PER Périodiques Résumé : AbstractIntroduction Autism is a neurodevelopmental disorder with a high co-occurrence with intellectual disability. Adults with Autism and intellectual disability have a high incidence of challenging behaviour, defined as repetitive self injurious or aggressive behaviour. We underwent a systemic review of the evidence for treating challenging behaviours in adults with Autism and intellectual disability. Methods A literature search was conducted using three large databases to extract studies on the treatment of challenging behaviour among adults with Autism and intellectual disability. Papers, which met this criterion, were reviewed and analysed to assess study evidence and quality. Results Seven articles were selected which included five agents: fluvoxamine, sertraline, clomipramine, risperidone, and ziprasidone. Randomized control studies of fluvoxamine and risperidone, provided efficacy for the treatment of challenging behaviour in adults with Autism and intellectual disability. Open label trials of sertraline, clomipramine and ziprasidone were also effective in treating challenging behaviours for this population. Discussion Risperidone and fluvoxamine provided the best evidence for treating challenging behaviour, and risperidone was the only medication with multiple trials showing its efficacy. Further studies are required to demonstrate the efficacy of psychopharmacology in treating challenging behaviours among adults with Autism and intellectual disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.803-813[article] Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review [Texte imprimé et/ou numérique] / Amanda SAWYER, Auteur ; Johanna K. LAKE, Auteur ; Yona LUNSKY, Auteur ; Shi-Kai LIU, Auteur ; Pushpal DESARKAR, Auteur . - p.803-813.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.803-813
Mots-clés : Autism Adults Challenging behaviours Psychopharmacology Intellectual disability Index. décimale : PER Périodiques Résumé : AbstractIntroduction Autism is a neurodevelopmental disorder with a high co-occurrence with intellectual disability. Adults with Autism and intellectual disability have a high incidence of challenging behaviour, defined as repetitive self injurious or aggressive behaviour. We underwent a systemic review of the evidence for treating challenging behaviours in adults with Autism and intellectual disability. Methods A literature search was conducted using three large databases to extract studies on the treatment of challenging behaviour among adults with Autism and intellectual disability. Papers, which met this criterion, were reviewed and analysed to assess study evidence and quality. Results Seven articles were selected which included five agents: fluvoxamine, sertraline, clomipramine, risperidone, and ziprasidone. Randomized control studies of fluvoxamine and risperidone, provided efficacy for the treatment of challenging behaviour in adults with Autism and intellectual disability. Open label trials of sertraline, clomipramine and ziprasidone were also effective in treating challenging behaviours for this population. Discussion Risperidone and fluvoxamine provided the best evidence for treating challenging behaviour, and risperidone was the only medication with multiple trials showing its efficacy. Further studies are required to demonstrate the efficacy of psychopharmacology in treating challenging behaviours among adults with Autism and intellectual disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 Suicidal Thoughts and Behaviours Among Autistic Adults Presenting to the Psychiatric Emergency Department: An Exploratory Chart Review / Patrick JACHYRA in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
PermalinkThe impact of child problem behaviors of children with ASD on parent mental health: The mediating role of acceptance and empowerment / Jonathan A. WEISS in Autism, 16-3 (May 2012)
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