Documents disponibles écrits par cet auteur

Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma / Katherine B. EHRLICH in Development and Psychopathology, 27-4 (Part 2) (November 2015) 

Public ISBD [article]  in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1547-1554 Titre : Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma Type de document : texte imprimé Auteurs : Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur Article en page(s) : p.1547-1554 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the ?2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time. En ligne : http://dx.doi.org/10.1017/S0954579415000930 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2736 [article] Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma [texte imprimé] / Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur . - p.1547-1554. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1547-1554 Index. décimale : PER Périodiques Résumé : Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the ?2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time. En ligne : http://dx.doi.org/10.1017/S0954579415000930 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2736

Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? / Katherine B. EHRLICH in Development and Psychopathology, 28-4 pt2 (November 2016) 

Public ISBD [article]  in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1273-1283 Titre : Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? Type de document : texte imprimé Auteurs : Katherine B. EHRLICH, Auteur ; Kharah M. Ross, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur Article en page(s) : p.1273-1283 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that the experience of early life adversity is a risk factor for a range of poor outcomes across development, including poor physical health in adulthood. The biological embedding model of early adversity (Miller, Chen, & Parker, 2011) suggests that early adversity might become embedded within immune cells known as monocytes/macrophages, programming them to be overly aggressive to environmental stimuli and insensitive to inhibitory signals, creating a “proinflammatory phenotype” that increases vulnerability to chronic diseases across the life span. We tested this hypothesis in the present study. Adolescent girls (n = 147) had blood drawn every 6 months across a 2.5-year period. To assess inflammatory responses to challenge, their monocytes were stimulated in vitro with a bacterial product, and production of the cytokine interleukin-6 was quantified. Hydrocortisone was added to cultures to assess the cells’ sensitivity to glucocorticoids’ anti-inflammatory signal. Using cluster analyses, we found that early life adversity was associated with greater odds of displaying a proinflammatory phenotype characterized by relatively larger interleukin-6 responses and relatively less sensitivity to glucocorticoids. In contrast, ongoing social stress was not associated with increasing odds of being categorized in the proinflammatory cluster. These findings suggest that early life adversity increases the probability of developing a proinflammatory phenotype, which, if sustained, could forecast risk for health problems later in life. En ligne : http://dx.doi.org/10.1017/s0954579416000845 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2943 [article] Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? [texte imprimé] / Katherine B. EHRLICH, Auteur ; Kharah M. Ross, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur . - p.1273-1283. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1273-1283 Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that the experience of early life adversity is a risk factor for a range of poor outcomes across development, including poor physical health in adulthood. The biological embedding model of early adversity (Miller, Chen, & Parker, 2011) suggests that early adversity might become embedded within immune cells known as monocytes/macrophages, programming them to be overly aggressive to environmental stimuli and insensitive to inhibitory signals, creating a “proinflammatory phenotype” that increases vulnerability to chronic diseases across the life span. We tested this hypothesis in the present study. Adolescent girls (n = 147) had blood drawn every 6 months across a 2.5-year period. To assess inflammatory responses to challenge, their monocytes were stimulated in vitro with a bacterial product, and production of the cytokine interleukin-6 was quantified. Hydrocortisone was added to cultures to assess the cells’ sensitivity to glucocorticoids’ anti-inflammatory signal. Using cluster analyses, we found that early life adversity was associated with greater odds of displaying a proinflammatory phenotype characterized by relatively larger interleukin-6 responses and relatively less sensitivity to glucocorticoids. In contrast, ongoing social stress was not associated with increasing odds of being categorized in the proinflammatory cluster. These findings suggest that early life adversity increases the probability of developing a proinflammatory phenotype, which, if sustained, could forecast risk for health problems later in life. En ligne : http://dx.doi.org/10.1017/s0954579416000845 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2943

The Role of Adolescent Attachment in Moderating and Mediating the Links Between Parent and Adolescent Psychological Symptoms / Susan S. WOODHOUSE in Journal of Clinical Child & Adolescent Psychology, 39-1 (January-February 2010) 

Public ISBD [article]  in Journal of Clinical Child & Adolescent Psychology > 39-1 (January-February 2010) . - p.51-63 Titre : The Role of Adolescent Attachment in Moderating and Mediating the Links Between Parent and Adolescent Psychological Symptoms Type de document : texte imprimé Auteurs : Susan S. WOODHOUSE, Auteur ; Fatima RAMOS-MARCUSE, Auteur ; Katherine B. EHRLICH, Auteur ; Stephanie WARNER, Auteur ; Jude CASSIDY, Auteur Année de publication : 2010 Article en page(s) : p.51-63 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study examined whether adolescent attachment security and attachment-related representations moderate and mediate, respectively, the link between parent symptoms (depressive and anxiety) and adolescent depressive symptoms. Participants were 189 (118 girls) eleventh graders and their parents in a community sample. Results showed that adolescent attachment moderated the connection between parent and adolescent symptoms; in most cases attachment security was more protective if both parents were high on anxiety symptoms or if one parent was high on anxiety but the other parent was low on depressive symptoms. Mediational analyses indicated that representations of their mothers as a secure base mediated the link between maternal and adolescent depressive symptoms. Perceptions of fathers as a secure base did not play a mediating role, although paternal depressive symptoms were associated with lower perceptions of the father as a secure base. Neither parent's anxiety symptoms were related to perceptions of the parent as a secure base or to adolescent depressive symptoms. En ligne : http://dx.doi.org/10.1080/15374410903401096 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=9768 [article] The Role of Adolescent Attachment in Moderating and Mediating the Links Between Parent and Adolescent Psychological Symptoms [texte imprimé] / Susan S. WOODHOUSE, Auteur ; Fatima RAMOS-MARCUSE, Auteur ; Katherine B. EHRLICH, Auteur ; Stephanie WARNER, Auteur ; Jude CASSIDY, Auteur . - 2010 . - p.51-63. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 39-1 (January-February 2010) . - p.51-63 Index. décimale : PER Périodiques Résumé : The present study examined whether adolescent attachment security and attachment-related representations moderate and mediate, respectively, the link between parent symptoms (depressive and anxiety) and adolescent depressive symptoms. Participants were 189 (118 girls) eleventh graders and their parents in a community sample. Results showed that adolescent attachment moderated the connection between parent and adolescent symptoms; in most cases attachment security was more protective if both parents were high on anxiety symptoms or if one parent was high on anxiety but the other parent was low on depressive symptoms. Mediational analyses indicated that representations of their mothers as a secure base mediated the link between maternal and adolescent depressive symptoms. Perceptions of fathers as a secure base did not play a mediating role, although paternal depressive symptoms were associated with lower perceptions of the father as a secure base. Neither parent's anxiety symptoms were related to perceptions of the parent as a secure base or to adolescent depressive symptoms. En ligne : http://dx.doi.org/10.1080/15374410903401096 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=9768

Trajectories of relationship stress and inflammatory processes in adolescence / Katherine B. EHRLICH in Development and Psychopathology, 28-1 (February 2016) 

Public ISBD [article]  in Development and Psychopathology > 28-1 (February 2016) . - p.127-138 Titre : Trajectories of relationship stress and inflammatory processes in adolescence Type de document : texte imprimé Auteurs : Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Nicolas ROHLEDER, Auteur ; Emma K. ADAM, Auteur Article en page(s) : p.127-138 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Researchers have identified cross-sectional links between interpersonal stress and inflammation. Little is known, however, about how these dynamics unfold over time, what underlying immune pathways might exist, or whether moderators such as race could alter the strength of the connection between interpersonal stress and inflammatory processes. We examined whether adolescent girls whose relationship trajectories were characterized by chronic stress would exhibit a proinflammatory phenotype marked by systemic inflammation, heightened cytokine responses to bacterial challenges, and resistance to the anti-inflammatory properties of cortisol. Significant Stress × Race interactions revealed that family stress trajectories predicted glucocorticoid sensitivity and peer stress trajectories predicted cytokine production for White but not Asian girls. Relationship stress trajectories were not associated with systemic inflammation, however. These findings suggest that particular subgroups of adolescent girls who face chronic and elevated stress in their close relationships may be at risk for disruptions to the immune system. En ligne : http://dx.doi.org/10.1017/S0954579415000334 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2786 [article] Trajectories of relationship stress and inflammatory processes in adolescence [texte imprimé] / Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Nicolas ROHLEDER, Auteur ; Emma K. ADAM, Auteur . - p.127-138. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.127-138 Index. décimale : PER Périodiques Résumé : Researchers have identified cross-sectional links between interpersonal stress and inflammation. Little is known, however, about how these dynamics unfold over time, what underlying immune pathways might exist, or whether moderators such as race could alter the strength of the connection between interpersonal stress and inflammatory processes. We examined whether adolescent girls whose relationship trajectories were characterized by chronic stress would exhibit a proinflammatory phenotype marked by systemic inflammation, heightened cytokine responses to bacterial challenges, and resistance to the anti-inflammatory properties of cortisol. Significant Stress × Race interactions revealed that family stress trajectories predicted glucocorticoid sensitivity and peer stress trajectories predicted cytokine production for White but not Asian girls. Relationship stress trajectories were not associated with systemic inflammation, however. These findings suggest that particular subgroups of adolescent girls who face chronic and elevated stress in their close relationships may be at risk for disruptions to the immune system. En ligne : http://dx.doi.org/10.1017/S0954579415000334 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2786